Antimicrobial susceptibility pattern of colistin resistance Klebsiella pneumoniae from clinical Isolates

Praveen Kumar Gautam; Shama Tomar

doi:10.53730/ijhs.v6nS5.10866

Authors

Praveen Kumar Gautam
pkgautam92@rediffmail.com
Research Scholar, Department of Microbiology, National Institute of Medical Sciences & Research, NIMS University Rajasthan, Jaipur
Shama Tomar Professor & Head, Department of Microbiology, National Institute of Medical Sciences & Research, NIMS University Rajasthan, Jaipur

Keywords:

Klebsiella pneumoniae, Gram negative Bacteria, Multi-drug Resistance, Colistin Resistance, Broth-micro dilution method, Minimum Inhibitory Concentration

Abstract

Background: There is very little information available in India about the prevalence of colistin-resistant Klebsiella pneumonia in patients and their susceptibility pattern. The increased use of colistin to treat infections are caused by multidrug-resistant Gram-negative bacteria has resulted in an increase of colistin resistance in Klebsiella pneumoniae in numerous countries. Materials and Methods: These isolates were collected from distinct clinical specimens and analyzed using the broth micro-dilution technique to establish their colistin minimal inhibitory concentration (mic). Result: Of 116 Klebsiella species, Klebsiella pneumonia was 96.55% while Klebsiella oxytoca was 3.45%. Among isolates, 09 (7.76%) were colistin resistant Klebsiella pneumonia by broth-micro dilution. In total, 09 case-patients were identified, 62.93% males and 37.07% females. The mean±SD of the age was 45.93±18.15. Carbapenem, Piperacillin-tazobactam and tigecycline were the most effective drug used for combine therapy to colistin resistance gram negative infections. Conclusion: This is the first study to look at the incidence of colistin-resistant Klebsiella pneumoniae in individuals in Jaipur. Infection caused by Klebsiella pneumonia highly resistant to many drugs. However, various colistin-based combined strategies have indeed been proven to be effective in curing these problems. To minimise colistin use and avoid misuse, a comprehensive antibiotic stewardship policy must be implemented.

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