Mortality prediction by prognostic scoring in Hepatitis C- associated or non- associated cirrhotic patients

Abstract

Objectives: Hepatitis C virus (HCV) is a hepatotropic virus that is one of the most common causes of liver disease and a potential cause of substantial morbidity and mortality worldwide. There is a paucity of data on the etiological profile of cirrhosis with HCV association in western Uttar Pradesh. Methodology: The observational type of study was carried out from June 2021 to May 2022 on patients attending in Medicine department at Lala Lajpat Rai Memorable Medical College, Meerut in collaboration with the Microbiology Department at National Capital Region Institute of Medical Sciences, Meerut, Uttar Pradesh, India. We included 247 patients who were diagnosed with cirrhosis, informed consent was taken with a 5 ml blood sample collected from each patient. The sample was screened for the qualitative detection of HCV-specific antibodies using 3rd generation Enzyme-linked immunosorbent assay (ELISA) from all the participants and Scored by the MELD score system. Result: A total of 247 confirmed cirrhosis patient’s, 52 (21%), patients were positive with the association of HCV in the age group of 41-60 and the mean age was 50 years. The 31 (59.6%) were males, and 21 (40.3%) were females positive for HCV in the low-status family.