Evaluating the role of muscular exercise in modulating the progress of peptic ulcer treated by quercetin or dexilant in male albino rats

Nesren Mohamed Mohamed Abo Edra; Mervat Hassan El Saka; Hala Fouad El-Baradey; Romysaa Ali El Sherbeny

doi:10.53730/ijhs.v6nS5.10913

Authors

Nesren Mohamed Mohamed Abo Edra
Nesrenmohamed8@yahoo.com
Physiology Department, Faculty of Medicine, Tanta University
Mervat Hassan El Saka Physiology Department, Faculty of Medicine, Tanta University
Hala Fouad El-Baradey Physiology Department, Faculty of Medicine, Tanta University
Romysaa Ali El Sherbeny Physiology Department, Faculty of Medicine, Tanta University

Keywords:

Muscular Exercise, Peptic Ulcer, Quercetin, Dexilant, ADMA, Bcl2, NF-kB

Abstract

Aim of the Work: Study the role of muscular exercise in modulating the progress of peptic ulcer treated by quercetin or dexilant in rats. Methods: 80 male rats divided into 8 equal groups: Control, gastric ulcer non-treated, gastric ulcer with exercise, dexilant treated gastric ulcer, quercetin treated gastric ulcer, dexilant treated gastric ulcer with exercise, quercetin treated gastric ulcer with exercise, quercetin and dexilant treated gastric ulcer groups. At the end, the collected samples were used to analyze PH, total gastric acidity, ulcer index(UI), curative index(CI), heat shock protein 70(HSP70), asymmetric dimethyle arginine(ADMA), tumor necrotic factor alpha(TNFα) levels. Histopathological and immunohistochemical analyses were done. Results: Non-treated group showed significant decrease of gastric levels of pH and CI with significant increase of gastric total acidity, UI, HSP70, ADMA and TNFα. Also, deterioration of histopathological and immunohistochemical expression of Bcl-2 with increase of NF-κB immunohistochemical expression compared to control group.

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