Lipid profile in obese children with and without insulin resistance
Obesity is increasing nowadays including in children and there is lack of information on the pathophysiology and their complication such as insulin resistance and dyslipidemia. This study was aimed to investigate the comparison of lipid profile in obese children with and without insulin resistance. A crossectional study held at an elementary school in Denpasar, Bali from August until September 2015. Independent t-test, Mann-Whitney test, and Multivariate analysis of covariance (MANCOVA) were performed to compare lipid profile in obese children with and without insulin resistance. A P-value less than 0.05 was considered statistically significant. A total of 50 obese children were analyzed. In this study, we found 12 subjects (24%) with insulin resistance. Nonsignificant associations were found between insulin resistance with total cholesterol, HDL, LDL, and ratio of HDL/LDL. A significant association was found between insulin resistance and triglyceride level after adjusted age and sex. There was a significant mean difference of triglycerides in the insulin resistance and noninsulin resistance groups in obese children.
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