High C-reactive protein/albumin ratio increased risk of acute malnutrition during hospitalization in pediatric patients

I Gusti Lanang Sidiartha; Dyah Kanya Wati; Ida Bagus Subanada; I Gusti Ngurah Made Suwarba

doi:10.29332/ijhs.v4n3.453

Authors

I Gusti Lanang Sidiartha
lanangsidiartha@yahoo.com
Department of Child Health, Medical Faculty, Udayana University, Denpasar, Indonesia
Dyah Kanya Wati Department of Child Health, Medical Faculty, Udayana University, Denpasar, Indonesia
Ida Bagus Subanada Department of Child Health, Medical Faculty, Udayana University, Denpasar, Indonesia
I Gusti Ngurah Made Suwarba Department of Child Health, Medical Faculty, Udayana University, Denpasar, Indonesia

Keywords:

albumin, CRP, inflammation, malnutrition, pediatric

Abstract

Pediatric patients with malnutrition commonly have poor prognosis related to the inflammation and catabolism state. This study investigated the relationship between high C-Reactive Protein/Albumin ratio on admission with the risk of acute malnutrition during hospitalization in pediatric patients. A cohort study in patients aged 1 month to 18 years old who met the study criteria was done. On admission, the level of serum C-Reactive Protein and Albumin were measured and calculated the C-Reactive protein/Albumin ratio which was divided into the high and low ratio. Acute malnutrition was determined according to the weight-for-height or body mass index-for-age z-score less than 2 SD below the WHO Child Growth Standard median. A total of 110 patients were analyzed, 50% male and the mean aged was 77.7 months. Patients with acute malnutrition on admission and discharge were 24.5% and 32.7%, respectively. Acute malnutrition on discharge in patients with high and low ratio were 51.6% and 25.3%, respectively (adjusted Relative Risk, 9.1; 95% CI: 1. 9 to 42.7; p = 0.005). High C-Reactive Protein/Albumin ratio on admission increased the risk of acute malnutrition during hospitalization in pediatric patients.

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