Study on primary non-small cell lung cancer with special reference to immunohistochemistry, EGFR mutation and K-RAS mutation in a tertiary care hospital

Nrusingha Charan Dash; Manoranjan Dash; Biswal Pradipta Trilochan; Pravin G. Dhone; Biswabikash Mishra; Jyoti Patnaik

doi:10.53730/ijhs.v6nS6.11021

Study on primary non-small cell lung cancer with special reference to immunohistochemistry, EGFR mutation and K-RAS mutation in a tertiary care hospital

https://doi.org/10.53730/ijhs.v6nS6.11021

Authors

Nrusingha Charan Dash Assistant Professor, Department of Pulmonary Medicine, SCBMCH, Cuttack
Manoranjan Dash Associate Professor, Department of Pulmonary Medicine, SCBMCH, Cuttack
Biswal Pradipta Trilochan Assistant Professor, Department of Pulmonary Medicine, SCBMCH, Cuttack Pravin G. Dhone* Professor & Head, Department of Pharmacology, RSDKS GMC, Ambikapur
Pravin G. Dhone Professor & Head, Department of Pharmacology, RSDKS GMC, Ambikapur
Biswabikash Mishra S.R, Department of Pulmonary Medicine, SCBMCH, Cuttack
Jyoti Patnaik Professor, Department of Pulmonary Medicine, SCBMCH, Cuttack

Keywords:

NSCLC- non-small cell lung cancer, adeno carcinoma, squamous cell carcinoma, EGFR- epidermal growth factor receptor, K-RAS- Kristen rat sarcoma

Abstract

Background: In lung cancers the use of immunohistochemistry is recommended for those cases in which diagnosis is unclear between adenocarcinoma and squamous cell carcinoma. This study is to know the different mutations in NSCLC of the lungs in our tertiary care centre. Aims & Objectives: To study clinical and radiological correlation with different histological types of primary lung cancer with refence to immunohistochemistry TTF-1 and p63 and to detect EGFR, KRAS mutation. Material & Methods: The study was conducted in a tertiary care centre of Odisha during the period from Sept. 2019 to Sept. 2021. 40 patients of age >18yrs with strong clinical suspicion and/or chest radiographic diagnosis of primary lung cancer are included in this study from IPD of Pulmonary Medicine Department, SCB MCH, Cuttack after taking into account inclusion and exclusion criteria. Results: Most of the cases were in the 5^th & 6^th decade of age with mean age of 58.8yrs. Most males (57.5%) in the study were smoker and all females were Never-Smokers. EGFR mutation found in 7 cases out of 20 Adenocarcinoma (35%) and 2 cases out of 19 Squamous cell carcinomas (10.5%). K-RAS mutation was detected in 1 adenocarcinoma patient (5%).

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References

Clinic pathologic profile of bronchogenic carcinoma among female in north india: R Prasad et al 2015

Clinico-pathological profile of lung cancer in Uttarakhand Jagdish Rawat, Girish Sindhwani, Dushyant Gaur1, Ruchi Dua, Sunil Saini2.

Guleria JS, Gopinath N et al. Bronchial carcinoma an analysis of 120 cases, J .Ass. Phy .India 1971; 19:251-55.

Jindal S.K, Behera D. clinical spectrum of primary lung cancer review of Chandigarh experience of 10 years. Lung India 1990; 8:94-98

Lung cancer at a university hospital in SaudiArabia:a 4 year prospective study of clinical, pathological, radiological , bronchoscopic,and biochemical parameters. Omer S Almoudi. Annals of thoracic medicine 2010 jan-mar

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864

Widjaja, G. (2021). Impact of human resource management on health workers during pandemics COVID-19: systematic review. International Journal of Health & Medical Sciences, 4(1), 61-68. https://doi.org/10.31295/ijhms.v4n1.850

Published

25-07-2022

How to Cite

Dash, N. C., Dash, M., Trilochan, B. P., Dhone, P. G., Mishra, B., & Patnaik, J. (2022). Study on primary non-small cell lung cancer with special reference to immunohistochemistry, EGFR mutation and K-RAS mutation in a tertiary care hospital. International Journal of Health Sciences, 6(S6), 6450–6456. https://doi.org/10.53730/ijhs.v6nS6.11021

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Issue

Vol. 6 No. S6 (2022)

Section

Peer Review Articles

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