Study on primary non-small cell lung cancer with special reference to immunohistochemistry, EGFR mutation and K-RAS mutation in a tertiary care hospital
Keywords:
NSCLC- non-small cell lung cancer, adeno carcinoma, squamous cell carcinoma, EGFR- epidermal growth factor receptor, K-RAS- Kristen rat sarcomaAbstract
Background: In lung cancers the use of immunohistochemistry is recommended for those cases in which diagnosis is unclear between adenocarcinoma and squamous cell carcinoma. This study is to know the different mutations in NSCLC of the lungs in our tertiary care centre. Aims & Objectives: To study clinical and radiological correlation with different histological types of primary lung cancer with refence to immunohistochemistry TTF-1 and p63 and to detect EGFR, KRAS mutation. Material & Methods: The study was conducted in a tertiary care centre of Odisha during the period from Sept. 2019 to Sept. 2021. 40 patients of age >18yrs with strong clinical suspicion and/or chest radiographic diagnosis of primary lung cancer are included in this study from IPD of Pulmonary Medicine Department, SCB MCH, Cuttack after taking into account inclusion and exclusion criteria. Results: Most of the cases were in the 5th & 6th decade of age with mean age of 58.8yrs. Most males (57.5%) in the study were smoker and all females were Never-Smokers. EGFR mutation found in 7 cases out of 20 Adenocarcinoma (35%) and 2 cases out of 19 Squamous cell carcinomas (10.5%). K-RAS mutation was detected in 1 adenocarcinoma patient (5%).
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