Microencapsulation of celecoxib using various methods and polymers
Keywords:
microencapsulation, celecoxib, spray drying, pan coating, fluid bed coating, solvent evaporation, PVP, polymers, non-steroidal anti-inflammatory drugAbstract
Microencapsulation is a process in which active substances are coated by extremely small capsules. It is a new technology that has been used in the cosmetics industry as well as in the pharmaceutical, agrochemical and food industries, being used in flavours, acids, oils, vitamins, microorganisms, among others. This paper provides an UpToDate review of different microencapsulation methods and polymers used specifically for Celecoxib drug. As Celecoxib is poorly soluble in water, there are several methods used to improve solubility and bioavailability using various polymers. The different microencapsulation methods along with different polymers were studied and given a comprehensive review. There are several NSAIDs which are used for pain management and Celecoxib is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation, and menstrual symptoms. There are many techniques available that can be used to fabricate microcapsules based on desired characteristics, and applications of the final microcapsule formulation. For Celecoxib microencapsulation, Spray drying techniques are widely used method for the research studies. some of the advantages of spray-drying include its ability to be fully automated and continuous.
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Adriana Raffin Pohlmann, Francisco Noe Fonseca, Karina Paese, Cassia Britto Detoni, Karine Coradini, Ruy CR Beck & Silvia S Guterres; (2013); Poly(e-caprolactone) microcapsules and nanocapsules in drug delivery; Exper Opinion Drug delivery,
Alenka Zvonar, Julijana Kristl, Janez Kerc and Pegi Ahlin Grabnar; High celecoxib-loaded nanoparticles prepared by a vibrating nozzle device; Journal of Microencapsulation, 2009; 26(8): 748–759
Alireza Homayounia, Fatemeh Sadeghib, Ali Nokhodchic,d Jaleh Varshosaze and Hadi Afrasiabi Garekanif; Preparation and Characterization of Celecoxib Dispersions in Soluplus®: Comparison of Spray Drying and Conventional Methods; Iranian Journal of Pharmaceutical Research (2015), 14 (1): 35-50
Bina Gidwani and Amber Vyas, (2015), A Comprehensive Review on Cyclodextrin-Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs, Hindawi Publishing Corporation, BioMed Research International Volume 2015, Article ID 198268
Catherine Tomaro-Duchesneau, Shyamali Saha, Review article Microencapsulation for the Theurapeutic Delivery of Drugs, Live mammalian and Bacerial cells, and other Biopharmaceutics, Current status and Failure directions, Journal of Pharmaceutics, Hindawi Publishing Corporation, Journal of Pharmaceutics, (2013), Article ID 103527.
E hab A. Fouad, Mahmoud EL-Badry, Gamal M. Mahrous, Fars K. Alanazil, Steven H. Neau, and Ibrahim A. Alsarra; The use of spray-drying to enhance celecoxib solubility; Drug Development and Industrial Pharmacy, 2011; 37(12): 1463–1472
Filomena Nazzaro, Pierangelo Orlando, Florinda Fratianni and Raffaele Coppola, Microencapsulation in food science and biotechnology; Current Opinion in Biotechnology 2012, 23:182–186
Gandamayu, I. B. M., Antari, N. W. S., & Strisanti, I. A. S. (2022). The level of community compliance in implementing health protocols to prevent the spread of COVID-19. International Journal of Health & Medical Sciences, 5(2), 177-182. https://doi.org/10.21744/ijhms.v5n2.1897
Hirenkumar K. Makadia and Steven J. Siegel, (2011), Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier; Polymers (Basel); 3(3): 1377–1397.
Hyeok Jin Kwon, Eun-Ji Heo, Young-Hwan Kim, Sarah Kim, Young-Ha Hwang, Ji-Mi Byun, Se Hyeop Cheon, Sang Yeob Park, Dong Yun Kim, Kwan Hyung Cho, Han-Joo Maeng and Dong-Jin Jang; Development and Evaluation of Poorly Water-Soluble Celecoxib as Solid Dispersions Containing Nonionic Surfactants Using Fluidized-Bed Granulation; Pharmaceutics 2019, 11, 136;
J. Brady, ... J.-X. Li; (2017); Developing Solid Oral Dosage Forms, Pharmaceutical Theory and Practice, Book (Second Edition), Chapter: Polymer properties and Charatcterization; ISBN 978-0-12-802447-8
Jie Chen, James D. Ormes, John D. Higgins, and Lynne S. Taylor; Impact of Surfactants on the Crystallization of Aqueous Suspensions of Celecoxib Amorphous Solid Dispersion Spray Dried Particles; Molecular Pharmaceutics Jan 2015;
Joana Filipa Parente, Vânia Isabel Sousa, Juliana Filipa Marques, Marta Adriana Forte, and Carlos José Tavares (2022), Biodegradable Polymers for Microencapsulation Systems; Advances in Polymer Technology Vol 2022
Kwan Hyung Chol, Jun-Pil Jee, Da A. Yang, Sung Tae Kim, Dongjin Kang, Dae-Young Kim, Taeyong Sim, Sang Yeob Park, Kyeongsoon Kim, and Dong-Jin Jang; Improved Dissolution and Oral Bioavailability of Celecoxib by a Dry Elixir System; Journal of Nanoscience and Nanotechnology, Vol. 18, 1482–1486, 2018
Madhuri Newa,Krishna H. Bhandari, Jung-Ae Kim,Bong-Kyu Yoo,Han-Gon Choi,Chul-Soon Yong,Jong-Soo Woo&Won-Seok Lyoo; (2008) Preparation and Evaluation of Fast Dissolving Ibuprofen-Polyethylene Glycol 6000 Solid Dispersions; Drug Delivery Volume 15, - Issue 6
Microencapsulation : A Review, S. S. Bansode*, S. K. Banarjee, D. D. Gaikwad, S. L. Jadhav, R. M. Thorat; International Journal of Pharmaceutical Sciences Review and Research; Volume 1, Issue 2, March – April 2010; Article 008
Miha Homara,b, Nathalie Ubrichc , Fatima El Ghazouanic , Julijana Kristlb , Janez Kerča , Philippe Maincentc; Influence of polymers on the bioavailability of microencapsulated celecoxib; Journal of Microencapsulation, Jan 2007, Vol. 24, No. 7, Pages 621-633.
MK Shahzad, M Ubaid and G Murtaza; Formulation and Optimization of Celecoxib-Loaded Microspheres Using Response Surface Methodology; Tropical Journal of Pharmaceutical Research October 2012; 11 (5): 695-702
Mudit Dixit, Ashwini G Kini and Parthasarthi K Kulkarni; Enhancing Solubility and Dissolution of Celecoxib by Spray Drying using Pluronic F 127; Indian Journal of Pharmaceutical Education and Research; 2011/ Vol 45/ Issue 4
Muhammad Khurram Shahzad, Mahboob-e-Rabbani, Asadullah Madni Mahmood Ahmad, Naveed Akhtar, Muhammad Usman, Muhammad Uzair, Mahtab Ahmad Khan, Hassan Ahmad and Md Ekwal; Characterization and In-Vitro Release Study of Celecoxib Microspheres Synthesized from Polymethacrylate and Polyvinyl Pyrolidone; J.Chem.Soc.Pak., Vol. 34, No. 3, 2012
R M Ottenbrite and R Javan, (2005), Biological Structures; Elsevier, pg 99 to 108
Renata Trindade Rigon and Caciano P. Zapata Noreña, Microencapsulation by spray-drying of bioactive compounds extracted from blackberry (rubus fruticosus), J Food Sci Technol. 2016 Mar; 53(3): 1515–1524.
Saeed Motallae, Azade Taheri, Alireza Homayouni, Preparation and characterization of solid dispersions of celecoxib obtained by spray-drying ethanolic suspensions containing PVP-K30 or isomalt; Journal of Drug Delivery Science and Technology vol 46 (2018);
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review; Paola Franco and Iolanda De Marco, Polymers 2020, MDPI
Vallabh prakashan 1st ed, 2002, Transdermal drug delivery page no. 411 to 413
Y. D. Pawar, K. L. Chaudhari and P. D. Chaudhrari; Development and Optimization of spray dried amorphous ternary system of Celecoxib using design of experiments; International Journal of Pharmaceutical science and Research, 2017, Vol 8 Issue 5,
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