Acute oral toxicity study of turmeric based herbal product in Sprague Dawley rats
Keywords:
acute toxicity study, histopathology, OECD guidelinesAbstract
The purpose of this study is to evaluate the acute oral toxicity study of the Turmeric based herbal product in the sprague dawley rats. Acute oral toxicity refers to those adverse effects occurring following oral administration of a single dose of a substance, or multiple doses given within 24 hours. The LD50 value, defined as the statistically derived dose that, when administered in an acute toxicity test, is expected to cause death in 50% of the treated animals in a given period, is currently the basis for toxicologic classification of chemicals. The test item, Turmeric based herbal product was evaluated for Acute Oral Toxicity in Sprague Dawley Rats as per the OECD Guideline No. 425 -Acute Oral Toxicity - Up-and-Down Procedure. Based on the results, it may be concluded that the LD50 of test item is >5000 mg/kg body weight as per OECD Guideline No. 425-Acute Oral Toxicity-Up-and-Down Procedure.
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