Evaluation of effectiveness of ginkgo biloba aqueous extract on some physiological parameters and cerebrum tissue in male albino rats treated with aluminum chloride
Keywords:
Cerebrum, Alzheimer, Beta Amyloid, Ginkgo biloba, Acetylcholine, Aluminum ChlorideAbstract
The current study aims to know the protective role of the aqueous extract of the Ginkgo biloba against cerebrum damage induced by Aluminum chloride (AlCl3) in male rats. 40 adult male rats were used, which were randomly divided into four equal groups (10 animals/group), the first group (G1) administered 1 ml/kg of tap water, the second group (G2) administered 10 mg / kg of AlCl3, the third group (G3) was administered 10 mg/kg of aqueous extract of the Ginkgo biloba ,while the fourth group animals (G4) were administered 10 mg/kg of AlCl3 and 10 mg/kg of Ginkgo biloba aqueous extract orally and daily for 30 days. Fasting blood samples were collected after the end of the experiment to study the following parameters: concentration of soluble acetylcholinesterase AChE(G1), membrane bound acetylcholinesterase AChE (G4), Neuronal Mitochondrial ATPase (Nmit ATPase), Cytochrome C oxidase (COX) , Tumor Necrosis Factor-α (TNF-α). The results showed that oral administration of AlCl3 caused significant increase (P<0.05) in the concentration of AChE (G1), TNF-α, and significant decrease (P<0.05) in the concentration of AChE (G4), Nmit ATPase and COX compared with the control group.
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