Serum leptin and resistin in type 1 and type 2 diabetes mellitus
Keywords:
leptin, resistin, insulin, diabetes mellitusAbstract
Background: Leptin is a hormone, secreted by adipocytes that control the food intake. It is an anorexigenic hormone, which leads to the suppression of appetite. Obesity is characterized by hyperleptinemia due to the development of leptin resistance 1. Resistin is a adipokine, resisting insulin secreted from scortal cell and macrophages of adipose cell. Diabetes is a chronic disorder presenting with high blood sugar values, either due to less production of insulin or insulin insensitivity. These adipokines have a direct correlation with diabetes. So their levels tend to vary in diabetes. Aim: To estimate the levels of Serum Leptin, Resistin, Insulin, FBS and lipid profile in Type 1 and Type 2 diabetes mellitus patient. Material and methods: A cross sectional analytical studies was conducted in DR B R AMC. Study group included 80 known case of diabetes mellitus. 40 patients type 1 DM in group 1 and 40 patients with Type 2 DM was included as group 2. Results: BMI, FBS, Lipid profile had no significant difference among both the groups. Insulin was high in type 1 diabetes mellitus, but with no statistical significance. Leptin levels are significantly high in Type 1 DM compared to type 2 DM.
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