Diagnostic value of serum ADA level in extra pulmonary tuberculosis cases in a tertiary care hospital, Bihar

https://doi.org/10.53730/ijhs.v6nS7.11659

Authors

  • Nitali Arun Senior Resident, Dept. Of Microbiology, IGIMS, Patna
  • Rakesh Kumar Additional Professor, Dept. Of Microbiology, IGIMS, Patna
  • Randhir Kumar Assistant Professor, Dept. Of Microbiology, IGIMS, Patna
  • Anand Dev Assistant Professor, Dept. Of Emergency Medicine, IGIMS, Patna
  • Sweta Muni Assitant Professor, Dept. Of Microbiology, IGIMS, Patna
  • Nidhi Prasad Associate Professor, Dept. Of Microbiology, IGIMS, Patna

Keywords:

Extrapulmonary tuberculosis, Serum Adenosine deaminase, Diagnosis Introduction

Abstract

Travelling through time, space and history if there is one disease which always comes to our mind is tuberculosis (TB). Still on many occasions it remains undiagnosed and hence not treated appropriately. In many instances patient is not able to give proper sputum sample or in a way it should be. On the top of it in resource poor countries availability of health care professionals is an issue to examine the sputum. Furthermore, when extra pulmonary TB is the case invasive diagnostic procedures such as biopsy becomes important which is a challenging thing to perform in many of our setups in our state. So, the aim of this study was to investigate the diagnostic value of ADA in extra pulmonary TB. Methods: It is an analytical study in which serum ADA values in EPTB cases were compared with controls.100 patients matched for age and sex were included. Data analysis was done using SPSS version 27. Results: Our data analysis showed mean ADA levels in EPTB patients was 43.6 which was significantly higher than control group(p value <0.001).

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References

WHO global TB report 2021, Annexure2;Who global TB database; 32

World health organisation global TB report 2021,Annexure3;Who global list of high burden countries;34

3.World Health Organization Global tuberculosis report 2017;Chapter3,TB disease burden 21

4.Kuyucu N, Karakurt C, Bilaloğlu E, Karacan C, Teziç T. Adenosine deaminase in childhood pulmonary tuberculosis: Diagnostic value in serum. J Trop Pediatr. 1999; 45:245–7.

5.Barua R, Hossain M. Adenosine deaminase in diagnosis of tuberculosis: a review. Anwer Khan Mod Med Coll J. 2014; 5:43–8.)

6.Mathur PC, Tiwari KK, Trikha S, Tiwari D. Diagnostic value of adenosine deaminase (ADA) activity in tubercular serositis. Indian J Tuberc. 2006;53(2):92-5.

7.Khan FY, Hamza M, Omran AH, Saleh M, Lingawi M, Alnaqdy A, et al. Diagnostic value of pleural fluid interferon-gamma and adenosine deaminase in patients with pleural tuberculosis in Qatar. Int J Gen Med. 2013;6:13-8. doi: 10.2147/ijgm. s39345.

8.Prashant Chikkahonnaiah1 , Surabhi Jaggi2 , Bela Goyal3 and etal, Utility of serum ADA estimation in the diagnosis of extrapulmonary tuberculosis, JMSCR Vol||05||Issue||05||Page 21549-21553||May

9.Salmanzadeh S Mahsa Soleimani2 , Mohammad Javad Mohammadi3 , etal. Diagnostic Value of Serum Adenosine Deaminase (ADA) Level for Pulmonary Tuberculosis. Avicenna Journal of Clinical Microbiology and Infection. 2018 doi:10.15171/ajcmi.2018.xx).

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

10.Farazi A, Moharamkhani A, Sofian M. Validity of serum adenosine deaminase in diagnosis of tuberculosis. Pan Afr Med J. 2013; 15:133.)

11.Agarwal MKN, Mukerji PK, Srivastava VML. A study of serum adenosine deaminase activity in sputum negative patients of pulmonary tuberculosis. Ind L Tub. 1991; 38:139

12.Chander A, Shrestha CD. Diagnostic Value of Serum Adenosine Deaminase Levels in Sputum Smear Negative Pulmonary Tuberculosis Patients InNepalese Population, Asian Pacific Journal of Tropical Biomedicine, 2012: S1896 - S1899.)

13.Imtiaz Ahmed, Sadia Sabah, Md. BillalAlam, Md. Nazmul Hasan, ABM Abdullah. Role of Serum ADA in Patients of Extra-Pulmonary Tuberculosis in a Tertiary Care Hospital of Bangladesh. Int J Med Res Prof. 2020 May; 6(3): 63-67. DOI:10.21276/ijmrp.2020.6.3.0140)

Published

09-08-2022

How to Cite

Arun, N., Kumar, R., Kumar, R., Dev, A., Muni, S., & Prasad, N. (2022). Diagnostic value of serum ADA level in extra pulmonary tuberculosis cases in a tertiary care hospital, Bihar. International Journal of Health Sciences, 6(S7), 1759–1767. https://doi.org/10.53730/ijhs.v6nS7.11659

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Section

Peer Review Articles