Duodenal ulcer and gastric cancer patients infected with Helicobacter Pylori in AL-Najaf City, Iraq

https://doi.org/10.53730/ijhs.v6nS5.11790

Authors

  • Hasanain Ihsan Hadi Department of Biology, Faculty of Science, University of Kufa, Iraq
  • Muslim Abdulkareem Enaya Sub-specialist Gastroenterologist and Hepatologist, Najaf GIT center, Iraq
  • Muslim Abdulkareem Enaya Sub-specialist Gastroenterologist and Hepatologist, Najaf GIT center, Iraq
  • Ahmed Abduljabbar Jaloob Aljanaby Department of Biology, Faculty of Science, University of Kufa, Iraq

Keywords:

Duodenal Ulcer, Gastric Cancer, Male, Female, Helicobacter Pylori

Abstract

A case-control study was carried out in Al- Sader Medical City in AL-Najaf Governorate, Iraq, during period from 1/9/2021 to 1/3/2022. Helicobacter pylori (H. pylori) Antigen Rapid Test Cassette (Feces) has been used to diagnosis all patients infected with H. pylori. All patients with duodenal ulcers and gastric cancer have been diagnosed by a physician using an endoscope and biopsy, respectively, in the department of tumors at AL-Sader Medical City. The results proved that there were 27 patients; 11 male (40.7%) and 16 female (59.3%) infected with H.pylori. Age group 20-30 was the highest infected with H.pylori (14 patients, 51.9%) followed by 31-40 (8 patients 29.6%), 41-50 (4 patients 14.8%) and 51-60 (1 patient 3.7%). Conclusions: Helicobacter Pylori may cause the most cases of duodenal ulcer and gastric cancer in patients that infected with this bacterium.

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References

Alipour, M., 2020. Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer. Journal of gastrointestinal cancer, pp.1-8. doi.org/10.1007/s12029-020-00518-5

Aljanaby, A.A.J., Al-Faham, Q.M.H., Aljanaby, I.A.J. and Hasan, T.H., 2022. Immunological role of cluster of differentiation 56 and cluster of differentiation 19 in patients infected with mycobacterium tuberculosis in Iraq. Gene Reports, p.101514. doi.org/10.1016/j.genrep.2022.101514

Chonwerawong, M. and Ferrero, R.L., 2017. Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection. Microbes and infection, 19(9-10), pp.449-458. doi: 10.1016/j.micinf.2017.06.005

Eslami, M., Yousefi, B., Kokhaei, P., Arabkari, V. and Ghasemian, A., 2019. Current information on the association of Helicobacter pylori with autophagy and gastric cancer. Journal of cellular physiology, 234(9), pp.14800-14811. doi.org/10.1002/jcp.28279

Hadi, H. I. and Aljanaby, A. A. J. (2022). Helicobacter Pylori-oncogenic protein cytotoxin-associated gene A and assessment of CD14 and CD163 in duodenal ulcer and gastric cancer patients. International Journal of Health Sciences, 6(S2), 839–851. https://doi.org/10.53730/ijhs.v6nS2.5134

Jolaiya, T.F., Fowora, M.A., Onyekwere, C., Ugiagbe, R., Agbo, I.I., Lesi, O., Ndububa, D.A., Adekanle, O., Njom, H.A., Idowu, A. and Adeleye, I.A., 2020. Duodenal ulcer promoting gene (DupA), plasticity region genes and sigma factors in H. pyloristrains from Nigeria. The Journal of Infection in Developing Countries, 14(02), pp.162-168. doi: 10.3855/jidc.11746

Lehours, P. and Robinson, K., 2020. Helicobacter, inflammation, immunology and vaccines. Helicobacter, 25, p.e12737. doi: 10.1111/hel.12737

Medhat, A. R., and Aljanaby, A. A. J. (2022). Assessment of some immune markers in typhoid-patients: A case control study . International Journal of Health Sciences, 6(S1), 4199–4210. https://doi.org/10.53730/ijhs.v6nS1.5592

Mohammed, E.H. and Aljanaby, A.A.J., 2020. Galectin3 and CD16 play an important immunological role in patients infected with Salmonella typhi. Int. J. Res. Pharm. Sci., 2020, 11(3), 4162-4169

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Thaib, P. K. P., & Rahaju, A. S. (2022). Clinicopathological profile of clear cell renal cell carcinoma. International Journal of Health & Medical Sciences, 5(1), 91-100. https://doi.org/10.21744/ijhms.v5n1.1846

Zhang, Q., Ding, J., Liu, J., Wang, W., Zhang, F., Wang, J. and Li, Y., 2016. Helicobacter pylori-infected MSCs acquire a pro-inflammatory phenotype and induce human gastric cancer migration by promoting EMT in gastric cancer cells. Oncology letters, 11(1), pp.449-457. doi: 10.3892/ol.2015.3897

Zhuang, Y., Cheng, P., Liu, X.F., Peng, L.S., Li, B.S., Wang, T.T., Chen, N., Li, W.H., Shi, Y., Chen, W. and Pang, K.C., 2015. A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis. Gut, 64(9), pp.1368-1378. doi: 10.1136/gutjnl-2014-307020

Published

15-08-2022

How to Cite

Hadi, H. I., Enaya, M. A., Enaya, M. A., & Aljanaby, A. A. J. (2022). Duodenal ulcer and gastric cancer patients infected with Helicobacter Pylori in AL-Najaf City, Iraq. International Journal of Health Sciences, 6(S5), 8789–8793. https://doi.org/10.53730/ijhs.v6nS5.11790

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Peer Review Articles