Correlation between CD14 and CD163 in duodenal ulcer and gastric cancer patients infected with Helicobacter Pylori
Keywords:
Correlation, CD14, CD163, Helicobacter pylori, duodenal ulcer, gastric cancerAbstract
Most people around the world are infected with Helicobacter pylori (H.pylori); it can lead to duodenal ulcer (DU) and gastric cancer (GC). The main objective of this study is to determine the correlation between CD14 and CD163 in individuals with DU and GC infected with H.pylori. Sixty nine individuals were included in this work; 27 patients infected with H.pylori only (H.Pylori+), 22 patients infected with H.pylori with DU and 20 patients infected with H.pylori with GC. CD14 and CD163 were measured in all individuals' serum using the Enzyme-Linked Immunoassay (ELISA) test. The results proved there was negative correlation between CD14 and CD163 in H.pylori-positive patients (y= -0.0263x+1.4179). While, there was positive correlation in H.pylori-positive patients with DU (y= 0.0932x+1.6647) and with GC (y= 0.0607x + 1.9824). In conclusion: CD14 and CD163 have a synergistic protected effect in H.pylori-positive patients with DU and GC.
Downloads
References
Alhasnawi, H.M.R, Aljanaby, A.A.J., 2022a. The immunological role of CD4 and CD8 in patients infected with Helicobacter pylori and stomach cancer. Gene Reports 26. 101500. https://doi.org/10.1016/j.genrep.2022.101500
Alhasnawi, H.M.R, Aljanaby, A.A.J., 2022b Evaluation of Galectin-3 and CD19 in Helicobacter pylori patients infected with stomach cancer. Gene Reports 26 (2022) 101520. https://doi.org/10.1016/j.genrep.2022.101520.
Aljanaby, A.A.J., Al-Faham, Q.M.H., Aljanaby, I.A.J. and Hasan, T.H., 2022a. Epidemiological study of Mycobacterium Tuberculosis in Baghdad Governorate, Iraq. Gene Reports, 26.101467. doi.org/10.1016/j.genrep.2021.101467
Aljanaby, A.A.J., Al-Faham, Q.M.H., Aljanaby, I.J., Hasan, H.H., 2020b. Immunological role of cluster of differentiation 56 and cluster of differentiation 19 in patients infected with mycobacterium tuberculosis in Iraq. Gene Reports, 26.101514. doi.org/10.1016/j.genrep.2022.101514
Amieva, M.R. and El–Omar, E.M., 2008. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology, 134(1), pp.306-323. doi.org/10.1053/j.gastro.2007.11.009
Ansari, S. and Yamaoka, Y., 2020. Helicobacter pylori virulence factor cytotoxin-associated Gene A (CagA)-mediated gastric pathogenicity. International Journal of Molecular Sciences, 21(19), p.7430. doi: 10.3390/ijms21197430.
Chonwerawong, M. and Ferrero, R.L., 2017. Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection. Microbes and infection, 19(9-10), pp.449-458. doi: 10.1016/j.micinf.2017.06.005
Eslami, M., Yousefi, B., Kokhaei, P., Arabkari, V. and Ghasemian, A., 2019. Current information on the association of Helicobacter pylori with autophagy and gastric cancer. Journal of cellular physiology, 234(9), pp.14800-14811. doi.org/10.1002/jcp.28279
Etzerodt, A. and Moestrup, S.K., 2013. CD163 and inflammation: biological, diagnostic, and therapeutic aspects. Antioxidants & redox signaling, 18(17), pp.2352-2363. DOI: 10.1089/ars.2012.4834
Hadi, H. I. and Aljanaby, A.A.J. 2022. Helicobacter Pylori-Oncogenic Protein Cytotoxin-Associated Gene A and Assessment of CD14 and CD163 in Duodenal Ulcer and Gastric Cancer Patients. International Journal of Health Sciences, 6(S2), 839–851. https://doi.org/10.53730/ijhs.v6nS2.5134
Hasan, T.H., Alasedi, K.K. and Aljanaby, A.A.J., 2021. A Comparative Study of Prevalence Antimicrobials Resistance Klebsiella pneumoniae among Different Pathogenic Bacteria Isolated from Patients with Urinary Tract Infection in Al-Najaf City, Iraq. Latin American Journal of Pharmacy, 40 (special issue): 174-8. http://www.latamjpharm.org/previous_issue.php?vol=0&num=1
Hobsley, M., Tovey, F.I. and Holton, J., 2008. Controversies in the Helicobacter pylori/duodenal ulcer story. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102(12), pp.1171-1175. doi:10.1016/j.trstmh.2008.04.035
Hou, J., Wang, X., Zhang, M., Wang, M., Gao, P. and Jiang, Y., 2019. Circulating CD14+ CD163+ CD209+ M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients. Molecular immunology, 108, pp.13-22. doi.org/10.1016/j.molimm.2019.01.017
Lehours, P. and Robinson, K., 2020. Helicobacter, inflammation, immunology and vaccines. Helicobacter, 25, p.e12737. doi: 10.1111/hel.12737
Medhat, A.R. and Aljanabay, A.A.J. 2022. Epidemiology of Typhoid Fever in Balad City, Iraq. International Journal of Health Sciences, 6(S1), 1049-1063.https://doi.org/10.53730/ijhs.v6nS1.4834
Pichon, M., Pichard, B., Barrioz, T., Plouzeau, C., Croquet, V., Fotsing, G., Chéron, A., Vuillemin, É., Wangermez, M., Haineaux, P.A. and Vasseur, P., 2020. Diagnostic accuracy of a noninvasive test for detection of Helicobacter pylori and resistance to clarithromycin in stool by the Amplidiag H. pylori+ ClariR real-time PCR assay. Journal of clinical microbiology, 58(4), pp.e01787-19. doi: 10.1128/JCM.01787-19
Raza, Y., Ahmed, A., Khan, A., Chishti, A.A., Akhter, S.S., Mubarak, M., Bernstein, C., Zaitlin, B. and Kazmi, S.U., 2020. Helicobacter pylori severely reduces expression of DNA repair proteins PMS2 and ERCC1 in gastritis and gastric cancer. DNA repair, 89, p.102836. doi: 10.1016/j.dnarep.2020.102836.
Sugano, K., 2019. Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis. Gastric cancer, 22(3), pp.435-445. DOI: 10.1007/s10120-018-0876-0
Waskito, L.A., Salama, N.R. and Yamaoka, Y., 2018. Pathogenesis of Helicobacter pylori infection. Helicobacter, 23, p.e12516. doi: 10.1111/hel.12516
Youssefi, M., Tafaghodi, M., Farsiani, H., Ghazvini, K. and Keikha, M., 2021. Helicobacter pylori infection and autoimmune diseases; Is there an association with systemic lupus erythematosus, rheumatoid arthritis, autoimmune atrophy gastritis and autoimmune pancreatitis? A systematic review and meta-analysis study. Journal of Microbiology, Immunology and Infection, 54(3), pp.359-369. doi: 10.1016/j.jmii.2020.08.011
Zhang, M., Ding, L., Wang, X., Hou, J., Li, M., Jiang, Y., He, X., Cui, M., Hu, F., Zhang, X. and Yang, J., 2018. Circulating CD14+ CD163+ CD115+ M2 monocytes are associated with the severity of new onset severe acute pancreatitis in Chinese patients. International immunopharmacology, 57, pp.181-189. doi: 10.1016/j.intimp.2018.02.018
Zhang, Q., Ding, J., Liu, J., Wang, W., Zhang, F., Wang, J. and Li, Y., 2016. Helicobacter pylori-infected MSCs acquire a pro-inflammatory phenotype and induce human gastric cancer migration by promoting EMT in gastric cancer cells. Oncology letters, 11(1), pp.449-457. doi: 10.3892/ol.2015.3897
Zhu, Q., Wu, X., Tang, M. and Wu, L., 2020. Observation of tumor-associated macrophages expression in gastric cancer and its clinical pathological relationship. Medicine, 99(17). doi: 10.1097/MD.0000000000019839
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
