The relationship between risk factor and clinical type of vitiligo in dermatology and venerology outpatient clinic Dr. Soetomo General Academic Hospital Surabaya

Alvian Arifin Saiboo; Diah Mira Indramaya; Afif Nurul Hidayati; Rahmadewi Rahmadewi; Damayanti Damayanti; Cita Rosita Sigit Prakoeswa

doi:10.53730/ijhs.v6nS5.12122

Authors

Alvian Arifin Saiboo Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Diah Mira Indramaya Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Afif Nurul Hidayati Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Rahmadewi Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Damayanti Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Cita Rosita Sigit Prakoeswa
cita-rosita@fk.unair.ac.id
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Keywords:

Vitiligo, risk factors, clinical type, treatment, human and disease

Abstract

Vitiligo is a skin and mucosa depigmentation condition caused by the loss of functioning melanocytes. Various pathological mechanisms are involved in melanocytes, their full details are often difficult to explain and several risk factors for vitiligo are thought to play a role. This study describe the relationship between risk factors and clinical type of vitiligo. This study is an analytic observational study with a retrospective cross sectional design based on the medical records patients who were treated in Dermatology and Venerology Outpatient Clinic Dr. Soetomo General Academic Hospital Surabaya. The result of this study found 115 new vitiligo patients with the following characteristics were female (53.9%), late adolescence (26.96%) and students (25.22%). The most common risk factors were idiopathic (51.3%) and emotional (28.7%). The most common clinical type was non-segmental vitiligo (53.04%). There was relationship between emotional and the clinical type of vitiligo (p=0.023 p<0.05) and there was relationship between idiopathic risk factors and the clinical type of vitiligo (p=0.019 p<0.05). There was relationship between emotional risk and idiopathic factors with the clinical type of vitiligo that were related to pathogenesis becomes important to understand to identify therapeutic targets and prognostic implications to stop the progression of the disease.

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References

Aboul-Fettouh, N., Pandya, A. G. (2018). ‘Epidemiology of vitiligo’. Wiley. Doi:10.1002/9781118937303.ch3.

Alkhateeb, A., Fain, P. R., Thody, A., Bennett, D. C., dan Spritz, R. A. (2003). ‘Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families’. Pigment Cell Res. 16(3): 208–14.

Bergqvist, C., dan Ezzedine, K. (2020). ‘Vitiligo: A Review’. Dermatology. 1-22.

Bilal, A., dan Anwar, I. (2016). ‘Guidelines for the management of vitiligo’. Journal of Pakistan Association of Dermatology, 24(1): 68-78.

Boniface, K., Seneschal, J., Picardo, M., Taïeb, A. (2017). ‘Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy’. Clin Rev Allergy Immunol. 54(1): 52–67.

de Castro, C. C., do Nascimento, L. M., Walker, G., Werneck, R. I., Nogoceke, E., Mira, M.T. (2010). ‘Genetic variants of the DDR1 gene are associated with vitiligo in two independent Brazilian population samples’. J Invest Dermatol.

Dwiyana, R. F., Marindani, V., Agustina, R., Setiawan, Sutedja, P. S. E. (2017). ‘Profil klinik-epidemiologi pada pasien vitiligo di RSUP Dr.Hasan Sakidin Bandung’. MKB. 49(2): 132-8.

Ezzedine, K., Lim, H.W., Suzuki, T., Katayama, I., Hamzavi, I., Lan, C.C., et al. (2012). ‘Vitiligo Global Issue Consensus Conference Panelists. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference’. Pigment Cell Melanoma Res. 25(3):E1–13.

Gaibullaeva, N. N. (2021). The role of clinical examination early diagnosis of glaucoma. International Journal of Health & Medical Sciences, 4(3), 333-337. https://doi.org/10.31295/ijhms.v4n3.1745

Han Shen, M., Yee Ng, C., Kuo‐Hsuan, C., Ching‐Chi, C. (2020). ‘Association of multiple sclerosis with vitiligo: a systematic review and meta‐analysis’. Scientific Reports. 10:17792.

Jeon, L. K., Park, C. J., Lee, M.H., Lee, D. Y., Kang, H. Y., Hann, S. K., et al. (2014). ‘A multicenter collaborative study by the korean society of vitiligo about patient’s occupationts and the provoking factors of vitiligo’. Ann Dermatol. 26(3): 349-56.

Jorge, M.T., Valenzuela-Onate, ̃ María, S. J., Cristian, Pedro, M. C., Altea, E. M., et al. (2020). ‘Experiencia en el uso de fototerapia en pacientes pediátricos y comparación de esta técnica frente a pacientes adultos,. Actas Dermosifiliogr. 111:41-6.

Khaitan, B. K., Kathuria, S., Ramam, M. (2012). ‘A descriptive study to characterize segmental vitiligo’. Indian Journal of Dermatology, Venereology, and Leprology. 78(6): 715.

Listiawan, M. Y. (2017). ‘Comparison between micropthalmia associated transcription factor (mitf) and s100 protein in vitiligo before and after therapy with narrowband ultraviolet b (nb-uvb)’. International Master Course on Aging Science (IMCAS).

Malhotra, N., Dytoc, M. (2013). ‘The pathogenesis of vitiligo’. Journal of Cutaneous Medicine and Surgery.17(3): 153–72.

Morrone, A., Picardo, M., de Luca, C., Terminali, O., Passi, S., Ippolito, F. (1992). ‘Catecholamines and vitiligo’. Pigment Cell Res 5:65-9.

Ongenae, K., Van Geel, N., De Schepper, S., Naeyaert, J. M. (2005). ‘Effect of vitiligo on self-reported health-related quality of life’. Br J Dermatol. 152:1165-72.

Orecchia GE. (2000). Neural pathogenesis. In: Hann S, Nordlund J, editors. Vitiligo. Oxford: Blackwell Science Ltd.

Parsad, D., Dogra, S., Kanwar, A. J. (2003). ‘Quality of life in patients with vitiligo’. Health Qual Life Outcomes. 1: 58.

Prasetya, S. Z., Rahmadewi. (2019). ‘Profil pasien vitiligo di Divisi Kosmetik Medik URJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya’.

Rahmawati YW, Indramaya DM. (2016). A Retrospective Study: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Berkala Ilmu Kesehatan Kulit dan Kelamin; 28(2):146-54.

Rahmayanti, N. D., Rahmadewi. (2016). ‘A retrospective studi: the profile of new patient with vitiligo’. Periodical of Dematology and Venereology. 28(2): 52-8.

Soepardiman, L. (2011). ‘Kelainan pigmen: vitiligo’. Ilmu Penyakit Kulit dan Kelamin. Jakarta: Fakultas Kedokteran Universitas Indonesia. 296- 8.

Speeckaert, R., Dugardin, J., Lambert, J., Lapeere, H., Verhaeghe, E., Speeckaert, M. M., van Geel, N. (2018). ‘Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis’. J Eur Acad Dermatol Venereol. 32(7):1089-98.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Szezurko, O., Shear, N., Taddio, A., et al. (2011). ‘Ginkgo biloba for the treatment of vitiligo vulgaris: an open label pilot clinical trial’. BMC Complement Altern Med. 11: 21.

Yuan, J., Sun, C., Jiang, S., Lu, Y., Zhang, Y., Gao, X.H, et al. (2019). ‘The prevalence of thyroid disorders in patients with vitiligo: A systematic review and meta-analysis’. Endocrinol. 9(803):1-13.