Evaluation of the relationship between vitamin D3 level and sex hormones in women with PCOS
Keywords:
PCOS, vitamin D3, luteinizing hormone, follicle-stimulating hormone, testosteroneAbstract
The current study included collection of 90 serum samples to assess the relationship between the level of vitamin D3 and some biochemical variables in women with polycystic ovarian syndrome. The samples were collected from external laboratories in Salah al-Din Governorate for the period from 10/29/2021 to 12/25/2021. 60 samples were taken for women with PCOS, and 30 samples were taken from the control group, their ages ranged between (18-40) years for healthy women and patients. Vitamin D3 level and some hormones concentrations (luteinizing hormone, follicle-stimulating hormone, and testosterone) were estimated in the blood serum of the study groups. The results of the current study showed that the level of vitamin D3 decreased significantly (P≤0.05) in women with PCOS compared to healthy women as a control group, the results showed a significant increase (P≤0.05) in the level of studding hormones (luteinizing hormone, follicle-stimulating hormone, and testosterone) in women with PCOS compared to healthy women as a control group.
Downloads
References
Abdallah, A. M., Elazab, G., Mosbeh, M. H., & Sarhan, H. (2021). Role of vitamin D and insulin resistance in polycystic ovary syndrome. Journal of advanced Biomedical and Pharmaceutical Sciences, 4(4), 186-194.
Abdulwahid, H. H., Hussein, B. A., Omran, Z. S., &Alhasanawy, S. A. (2019). Disorders of sex Hormones and lipid profile in obese and non-obese Women with Polycystic Ovary Syndrome (PCOS) in Karbala City. Annals of Tropical Medicine and Health, 22, 100-106.
Al-Tikriti, Sherine Bahgat. 2017. The role of hepcidin hormone and some biochemical variables in the sera of patients with polycystic ovary syndrome in Kirkuk. Doctoral thesis, College of Science, Tikrit University (6: 11): 22
Arianggara, A. W., Ernawati, E., Handayani, T. P., Sari, F., & Fitria, L. (2022). Relationship of information sources and knowledge with completeness of primigravida’s tetanus toxoid immunization. International Journal of Social Sciences and Humanities, 6(1), 75–84. https://doi.org/10.53730/ijssh.v6n1.4738
Bikle, D. Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & biology. 2014;21(3):319-29.
Brown, J. B. (1978). Pituitary control of ovarian function—concepts derived from gonadotrophin therapy. Australian and New Zealand Journal of Obstetrics and Gynaecology, 18(1), 47-54.
Conway, G. The Polycystic Ovary Syndrome. Department of Endocrinology. The Middle Sex Hospital Mortimer Street London W1N8AA. January . (2000).
Du, C.; Yang, S.; Zhao, X. and Dong, H. Pathogenic roles of alterations invitamin D and vitamin D receptor in gastric tumorigenesis. Oncotarget.2017;8(17):29474-86.
ElSirgany, S., Badawi, H., El-Khayat, Z., Bibers, M., Hamdy, M., Hamdy, A., ... &Alalfy, M. (2019). Serum fetuin a level: a new possible marker for polycystic ovarian syndrome in women with infertility. Obstetrics and Gynecology Research, 2(4), 100-107.
Escobar-Morreale, H. F. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nature Reviews Endocrinology, 14(5), 270-284.
Frhan, B. A. (2003). The effect of IVF Therapy on follicular fluid hormones infemal with lateal phase Defect. Thesis, MCS. Collage. Med. University. Baghdad.
HAISENLEDER, D. J., DALKIN, A. C., ORTOLANO, G. A., MARSHALL, J. C., & SHUPNIK, M. A. (1991). A pulsatile gonadotropin-releasing hormone stimulus is required to increase transcription of the gonadotropin subunit genes: evidence for differential regulation of transcription by pulse frequency in vivo. Endocrinology, 128(1), 509-517.
Herman, JP.; Prewitt, CM. and Cullinan. (1996). Neuronal circuit regulation of the hypothalamo, pituitary, adrenocortical stress axis. Crit.Rev.Neurobiol. ,10:371-394.
Hillier, S. G. (1993). Ovarian stimulation with recombinant gonadotrophins : LH as adjunct to FSH. In: Jacobs, H. S., ed. The new frontier in ovulation induction Carnforth, UK: Pathenon: 39-47.
Holick H. L. Biochemistry and physiology-Aspect of Nutrition. 4th Ed. Mosbey 2004.
Ibrahim, Z. M., Kishk, E. A., Fahmy, S. M., & Taha, O. T. (2020). Serum 1, 25-dihydroxy vitamin D-vitamin D3-among obese Egyptian women with polycystic ovary syndrome. ObstetGynecol, 4, 1-3.
Jäpelt, R.B and Jakobsen, J. Vitamin D in plants: a review of occurrence,analysis, and biosynthesis. Front. Plant Sci. 2013;4(136):1-20.
Jhon, G.R. competitive protein binding redio assay for 25(OH) D3. J.Clin. Endocr.Metab.1971;33:992-5.
Li, Y., Wang, J., Yang, J., Chen, J., Zhou, W., Qiao, C., ... & Bi, Y. (2021). The correlation between vitamin D, glucose homeostasis and androgen level among polycystic ovary syndrome patients: A cross-sectional study. Gynecological Endocrinology, 37(3), 235-239.
Liu, S., Hu, W., He, Y., Li, L., Liu, H., Gao, L., ... & Liao, X. (2019). Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome.
Mahdi, H. A., & Al-Samarrai, R. R. H. (2021). Evaluation the correlation between the level of asprosin and some biochemical parameters in women with polycystic ovary syndrome. Samarra Journal of Pure and Applied Science, 3(2), 12-24.
Nelson, VL.; Legro, RS.; Strauss, JF III. and McAllister, JM.( 1999). Augmented Androgen Production Is a Stable Steroidogenic Phenotype of Propagated Theca Cells from Polycystic Ovaries. Mol Endocrinol., 13:946‐957.
Nettore, I.C.; Albano, L.; Ungaro, P.; Colao, A. and Macchia, P.E.Sunshine vitamin and thyroid. Reviews in Endocrine and Metabolic Disorders. 2017;18(3):347-54
Nowson, C.A. and Margerison, C. Vitamin D intake and vitamin D status of Australians. Medical Journal of Australia. 2002;177(3):149-52.
Overes, H. W.; de Leeuw,R. and Kloosterboer, H. J. (1992). Regulation of aromatase activity in FSH-primed rat granulose cells in vitro by follicle stimulating hormone and various amounts of human chorionic gonadotropin .Hum. Rrprod.,7: 191-6
Paschou, S.A.; Anagnostis, P.; Karras, S. et al. Bone mineral density in men and children with haemophilia A and B: a systematic review and meta-analysis. Osteo Inter. 2014;25(10):2399-407
Patel, K., Coffler, M. S., Dahan, M. H., Malcom, P. J., Deutsch, R., & Chang, R. J. (2004). Relationship of GnRH‐stimulated LH release to episodic LH secretion and baseline endocrine‐metabolic measures in women with polycystic ovary syndrome. Clinical endocrinology, 60(1), 67-74.
Rachid, S.K.; O Rasheed, B.; M Jaff, P. and A Faraj, K. Vitamin D Status Among Women Living in Sulaimani, Kurdistan Region and HPLC-MS Analysis for MeasuringVitamin D in Organic and Non-organic Eggs.Kirkuk University Journal-Scientific Studies. 2017;12.2.
Sak, S., Uyanikoglu, H., Incebiyik, A., Incebiyik, H., Hilali, N. G., Sabuncu, T., & Sak, E. (2018). Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome. Clinical and Experimental Reproductive Medicine, 45(3), 116.
Stener-Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., ... & Abbott, D. H. (2020). Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome. Endocrine reviews, 41(4), bnaa010.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Turgeon, GL.; Kimura, Y.; Warimg, DW. And Mellon, PL.(1996). Steroid and puilsatile gonadotropin releasing hormone (GnRH) regulation of Luteinizing hormone and GnRH receptor on a novel gonadotrope cell line. Mol. Endocrinol., 10:439-45.
Ubaid, M. M., & Rahma, J. H. (2022). The effect of sex hormones on progression of Leishmania donovani infection in liver and spleen of BALB/c mice. International Journal of Health Sciences, 6(S3), 6327–6337. https://doi.org/10.53730/ijhs.v6nS3.7404
Vale, W.; Waiter, E.; Gray, P.; Harrison, C.; Bilezikjian, L. and Choe, SActives and Inhibins and their signaling .Annals of the New York Academy of Sciences. (2004); 1038:142-7
Wolf, W. M., Wattick, R. A., Kinkade, O. N., & Olfert, M. D. (2018). Geographical prevalence of polycystic ovary syndrome as determined by region and race/ethnicity. International journal of environmental research and public health, 15(11), 2589.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
