Evaluation of serum fibronectin, glutathione and malondialdehyde in breast cancer women
Keywords:
breast cancer, oxidative stress, fibronectin, antioxidants, malondialdehyde, glutathioneAbstract
Cancer is a term used to describe a group of disorders in which the body's cells alter and grow out of control. Most cancer cells eventually join together to create a mass known as a tumor, and are named according to the name of the part of the body from which the tumor originates. The Cancer is one of the diseases that have the ability to grow in unlimited fission of the body’s cells and the ability of these cells to attack and destroy nearby tissues or move through the blood to distant tissues and this is called a malignant tumor, and there is a second type characterized by specific growth and its inability to attack and move called "Benign tumor", which can develop into a malignant tumor. The goal of this research was to find out the levels of fibronectin and glutathione (GSH) as antioxidants and malaondialdehyde (MDA) as oxidative stress indicator in a group of patients of breast cancer and to compare the results with healthy one.
Downloads
References
Hinck, L. and Näthke, I. Changes in cell and tissue organization in cancer of the breast and colon. CurrOpin Cell Biol. 2014, 26: 87-95.
Ferlay, J., Soerjomataram, I., Ervik, M., Dikshit, S., Eser, C., Mathers, M., & Bray, F. G. L. O. B. O. C. A. N. (2012). V1. 0, cancer incidence and mortality worldwide: IARC Cancer Base No. 11. 2013. Lyon, France: International Agency for Research on Cancer.
Sariego, J. (2010). Breast cancer in the young patient. The American surgeon, 76(12), 1397-1400.
-Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010). Cancer statistics, 2010. CA: a cancer journal for clinicians, 60(5), 277-300.
Taih,NoorHazim,etal. Role of Triple Assessment in Detection of breast cancer in baquba teaching hospital.Diyala journal of Medicine.2020,19(1):113_119
TORRE, Lindsey A., et al. Global cancer statistics, 2012. CA: a cancer journal for clinicians, 2015, 65.2: 87-108
Wong, S. C. C., Chan, C. M. L., Ma, B. B. Y., Lam, M. Y. Y., Choi, G. C. G., Au, T. C. C., ... & Chan, A. T. C. (2009). Advanced proteomic technologies for cancer biomarker discovery. Expert review of proteomics, 6(2), 123-134.
Ruoslahti E, Engvall E, Hayman EG. Fibronectin: current concepts of its structure and functions. Collagen and related research. 1980 Dec 1;1(1):95-128
Yamada , K .; M . and Olden , K . Fibronectin adhesive glycoproteins of cell Surface and Blood , Nature ( london ) . 1978 ; 275 : 179 – 184.
PATTEN, Jennifer; WANG, Karin. Fibronectin in development and wound healing. Advanced Drug Delivery Reviews, 2021, 170: 353-368.
Nick, Miller. Blocking Fibronectin Protein Prevents Heart Failure, Restores Function . Biology Cincinnati Children's Heart Institute Health Heart Attack Medicine . 2018. 15.
Eman Taha Hamdi, Abdul Salam Tawfeeq Salih Alsamarai; The relaton ship between Vitamin D with breast cancer .2020,Medical science:24(104).
-DIX, Megan. Everything you should know about oxidative stress. Medically reviewed by Timothy J. Legg https://www. sciencedirect. com/science/article/pii/0278691594900116, 2017.
Mannaerts D, Faes E, Cos P, et al. Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function. PLoS One. 2018;13(9):e0202919. Published 2018 Sep 11. doi:10.1371/journal.pone.0202919
Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J ClinBiochem. 2015;30(1):11–26.
Sedlak, J. and Lindsay, R. H. “Analytical biochemistry” 1968 p.192 .cited by Al-Zamely. Al-Zamely, O. M.; Al-Nimer, M. S. and Muslih, R. K. Detection the level of peroxynitrite and related with antioxidants status in the serum of patient with acute myocardial infraction . Natl. J. Chem 2001; 4: 625-637
Guidet, B. and Shah, S. The level of malondialdehyde after activation with H2O2 and CuSO4 and inhibition by deferoxamine and molsidomine in the serum of patient with acute Myocardial infarction. National J. Chem,1989; 5, 139-148
FOSSATI, Plero; PRENCIPE, Lorenzo. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical chemistry, 1982, 28.10: 2077-2080.
MedCalcStatistical Software version 16.4.3 ( MedCalc Software bvba, Ostend, Belgium; https://www.medcalc.org; 2016)" IBM Corp. Released 2015. IBM SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM
Libring s, AparnaShinde, Monica K. Chanda et al. The Dynamic Relationship of Breast Cancer Cells and Fibroblasts in Fibronectin Accumulation at Primary and Metastatic Tumor Sites. Cancers 2020, 12(5), 1270; Accepted: 15 May 2020 / Published: 17 May 2020.
Zhuoran Gong, Min Chen et al. Fibronectin-targeted dual-acting micelles for combination therapy of metastatic breast cancer. Published: 07 February 2020. volume 5, Article number: 12 (2020) .
AparnaShinde, Sarah Libring, AktanAlpsoy. Autocrine Fibronectin Inhibits Breast Cancer Metastasis. DOI: 10.1158/1541-7786.MCR-18-0151 Published October 2018.
-Pankov, R.; Yamada, KM. "Fibronectin at a glance". Journal of Cell Science. October 2002; 115 (Pt 20): 3861–3.
Sechler, JL. Takada, Y.; Schwarzbauer, JE. Altered rate of fibronectin matrix assembly by deletion of the first type III repeats. J Cell Biol. 1996, 134: 573-583. 10.1083/jcb.134.2.573.
-Xu, M.; Mizoguchi, I.; Morishima, N.; Chiba, Y.; Mizuguchi, J. and Yoshimoto, T. Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27. Clinical and Developmental immunology. 2010;2010.
Valenick, LV.; Hsia, HC.;Schwarzbauer, JE. Fibronectin fragmentation promotes alpha4beta1 integrin-mediated contraction of a fibrin-fibronectin provisional matrix. Experimental Cell Research .September ,2005 ;309 (1): 48–55.
Pontiggia O, Sampayo R, Raffo D, Motter A, Xu R, Bissell MJ. et al. The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through beta1 integrin. Breast cancer research and treatment. 2012;133:459-71.
Nam JM, Onodera Y, Bissell MJ, Park CC. Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin. Cancer research. 2010;70:5238-48.
-HASSAN, M. S. U., et al. Chemotherapy for breast cancer. Oncology reports, 2010, 24.5: 1121-1131
Gao, C. et al. Amphiphilic drug conjugates as nanomedicines for combined cancer therapy. Bioconjugate Chem. 29, 3967–3981 (2018).
Szakacs, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C. & Gottesman, M. M. Targeting multidrug resistance in cancer. Nat. Rev. Drug Discov. 5, 219–234 (2006).
Rafal Ahmed Lilo ,RashaNayyef Ali et al. Evaluation of the oxidative state of women with breast cancer in AL-Hilla city. 2020, Volume , Issue 48, Pages 834-843.
Khalaf, Mohammed YaseenMSca et al. The correlation of antioxidant levels of breast cancer A case controlled study : September 03, 2021 - Volume 100 - Issue 35 - p e26878.
GhufranSaadNsaif, Amer Hassan Abdallah et al. Evaluation of Estridiol and Some Antioxidant in Breast Cancer Iraqi Women. 2018, Volume 21, Issue 1, Pages 35-40.
Bratt D, Kh J, Patel S, Zaveri M. Role of oxidative stress in breast cancer. Pharm PharmaceuSci 2016;5:366–79.
Gönenç A, Özkan Y, Torun M, Şimşek B. Plasma malondialdehyde (MDA) levels in breast and lung cancer patients. J Clin Pharm Ther 2001;26:141–4
Gupta, K.; Patel, K.; Kumari, R. ;Chugh, S. ; Shrivastav, C. ; Mehra, S. and Sharma, A. N.(2012). Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study. Asian Pacific J Cancer Prev., 13 (12): 6295-6298.
Motoyoshi, E ; Yutaka, Y. and Masahiro, N. (2014). serum ANGPTL2 levels reflect clinical features of breast cancer patients: implications for the pathogenesis of breast cancer metastasis. Int J Biol Markers, 29(3): 239 –245
Enrico Desideri , Fabio Ciccarone et al. Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy. Nutrients 2019, 11(8), 1926.
Chih-ChingYeh, Ming-FengHou et al. A study of glutathione status in the blood and tissues of patients with breast cancer. November 2006. DOI:10.1002/cbf.1275.
Luke Kennedy Jagdeep K. Sandhu et al. Role of Glutathione in Cancer: From Mechanisms to Therapies. Biomolecules 2020, 10(10), 1429.
VAIRETTI, Mariapia, et al. Changes in glutathione content in liver diseases: An update. Antioxidants, 2021, 10.3: 364.
YADAV, Anuj, et al. Antioxidants and its functions in human body-A Review. Res. Environ. Life Sci, 2016, 9.11: 1328-1331
Ahmad, P., Jamsheed, S., Hameed, A., Rasool, S., Sharma, I., Azooz, M. M., and Hasanuzzaman, M. Drought stress induced oxidative damage and antioxidants in plants. In Oxidative damage to plants 2014; (pp. 345-367). Academic Press.
Lu, S.C, S.C.2009. Regulation of glutathione synthesis. Mol. Aspects Med.30:42-59.
Wu,G.,Y.-Z Fang,S. Yang,G.R. Lupton, and N.D. Turner.2004. Glutathione metabolism and its implications for health. J. Nutr.134:489-492.
Narayanankutty, A.; Job, J. T. and Narayanankutty, V. Glutathione, an antioxidant tripeptide: Dual roles in Carcinogenesis and Chemoprevention. Current Protein and Peptide Science, 2019;20(9): 907-917.
HuanhuanLv ,Chenxiao Zhen.et al. Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy. Volume 2019 |Article ID 3150145 | https://doi.org/10.1155/2019/3150145.
- J. N. Moloney and T. G. Cotter, “ROS signalling in the biology of cancer,” Seminars in Cell & Developmental Biology, vol. 80, pp. 50–64, 2018.
-S. Galadari, A. Rahman, S. Pallichankandy, and F. Thayyullathil, “Reactive oxygen species and cancer paradox: to promote or to suppress?” Free Radical Biology and Medicine, vol. 104, pp. 144–164, 2017.
-M. L. Circu and T. Y. Aw, “Reactive oxygen species, cellular redox systems, and apoptosis,” Free Radical Biology and Medicine, vol. 48, no. 6, pp. 749–762, 2010.
-N. Traverso, R. Ricciarelli, M. Nitti et al., “Role of glutathione in cancer progression and chemoresistance,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 972913, 10 pages, 2013.
--P. T. Schumacker, “Reactive oxygen species in cancer: a dance with the devil,” Cancer Cell, vol. 27, no. 2, pp. 156-157, 2015.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
