The effect of PD-1 concentration level and its polymorphism in male infertility
Keywords:
Programmed death-1(PD-1), polymorphism, autoimmunity, male infertilityAbstract
Infertility has become a major public health issue, impacting a significant number of couples. This study aimed to examine the association of serum concentration level of PD-1 and its polymorphism with male infertility. The study consisted of 63 infertile male as a patients group their ages 33.37±0.86 years as well as 80 healthy fertile men each of them has at least one child, their ages 34.39±0.61) years also enrolled in this study were examined at Kamal Al-Samarrai Hospital for infertility and In vitro Fertilization from April 2021 until January 2022, excluded criteria included patients suffering from Varicocele (according to the clinical examination and ultrasonic waves), chronic diseases e.g. cardiovascular, diabetes mellitus, and hypertension, men with a history of specific childhood illnesses or conditions such as bilateral cryptorchidism or unilateral, testicular trauma the result showed there was significant differences between studied groups p≤0.05 the results of gene polymorphism after sequences showed that one of the SNPs is rs 741861 and when studied in in patients compared to controls showed that the genotype AG was risk factor infertility patients
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