A comparative study of oxidant and anti-oxidant parameters in chronic renal failure, haemodialysis (pre & post) and controls

M. Madan Mohan Rao; R. Salma Mahaboob; Obulesu Gundala

doi:10.53730/ijhs.v6nS6.12513

Authors

M. Madan Mohan Rao Associate Professor in General Medicine at Rajiv Government Medical college, Kadapa, Andhra Pradesh, India
R. Salma Mahaboob Associate Professor in Biochemistry at RSDKS Government Medical college and Hospital, Ambikapur, Chattisgarh. India
Obulesu Gundala
obulesu100@gmail.com
Associate Professor in Microbiology at RSDKS Government Medical college and Hospital, Ambikapur, Chattisgarh, India

Keywords:

malondialdehyde MDA, reactive oxygen species (ROS), chronic kidney disease, oxidative stress

Abstract

Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a complex disease due to cardiovascular complications and high morbidity; however, there is no single treatment to improve kidney function in CKD patients. Since biological markers representing oxidative stress are significantly elevated in CKD patients, oxidative stress is receiving attention as a contributing factor to CKD pathology. Aim of our study is comparison of oxidant and anti oxidant parameters in chronic renal failure, Hemodialysis (pre and post) and control subjects. Materials and Methods: The present study was conducted on a patient group comprising of 50 patients diagnosed with CRF, 50 were pre hemodialysis, 50 were post hemodialysis (MHD). This patient group was compared to a healthy group including 100 controls. All the study participants were admitted in the department of Medicine [Nephrology department] at “Rajiv Gandhi Institute Of Medical Sciences”, Kadapa. Andhra Pradesh. India. Study Period : July 2020 to December 2020 ,The obtained serum samples were used for biochemical analysis for estimating MDA, vitamin A and Glutathione Peroxidase (GPx).

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