Role of surrogate risk biomarkers for cardiovascular risk prediction in chronic kidney patients

Bhamidipaty Kanaka Durgaprasad; Rama Rao Malla; Bhamidipaty Durgananda Lahari; Bhamidipaty Veenadhari; Payala Vijayalakshmi; Kolli Viswa Kalyan

doi:10.53730/ijhs.v6nS8.12515

Authors

Bhamidipaty Kanaka Durgaprasad Professor, Department of Radiodiagnosis, GITAM Institute of Medical Sciences and Research, GITAM (Deemed to be University),Visakhapatnam-530045, Andhra Pradesh, India
Rama Rao Malla
dr.rrmalla@gmail.com
Professor, Cancer Biology Lab, Dept of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India
Bhamidipaty Durgananda Lahari III Year B.Tech Biotechnology, GIT, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India
Bhamidipaty Veenadhari I Year B.Tech Computer Science, GIT, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India
Payala Vijayalakshmi Assistant Professor, Department of Microbiology, GITAM Institute of Medical Sciences and Research, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India
Kolli Viswa Kalyan Professor, Department of Biochemistry, GITAM Institute of Medical Sciences and Research, GITAM (Deemed to be University), Visakhapatnam-530045, Andhra Pradesh, India

Keywords:

CKD, cardiovascular disease, H-FABP, CIMT, ACR

Abstract

Background: Biomarkers are quantifiable and repeatable biological indicators and some of them are used to predict cardiovascular events in individuals with chronic renal illness. Objectives: To assess, surrogate risk biomarkers like H-FABP, CIMT, serum albumin and A/C ratio in development of cardiovascular disease in stage III and stage IV CKD patients. Methods: It is a case control study, with sample size each of hundred cases and controls who were recruited from Nephrology department and present with chronic kidney disease – stage III / IV. B-model ultrasonography was employed for CIMT evaluation. H-FABP would be estimated using ELISA. Serum albumin in blood samples was determined using the bromocresol green. Urinary Albumin/creatinine ratio was expressed as milligram of albumin excreted per gram of urinary creatinine. Results: It was found that, there was a mean increase in the values of H-FABP and CIMT for cases compared to control population. However there was no much increase in mean values for serum albumin to control and case population. Conclusion: use of established and significant laboratory biomarkers like H-FABP, CIMT, ACR, Serum albumin concentration were really proven to be assessing the CKD risk in the general population.

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