Study of single nucleotide polymorphism of aquaporin 2 in hypertension and CKD patients
Keywords:
aquaporin-2, CKD, hypertension, polymorphismAbstract
The present study aims to examine the genetic variation of the Aquaporin-2 gene concerning hypertension and chronic kidney disease CKD. (120 ) blood samples from participants were obtained and divided into three groups: a first group representing hypertensive patients (hyper), a second group representing Hypertensive CKD patients (hyper with CKD), and a third group representing a control group. DNA was extracted from all blood samples and then converted to cDNA and the ARMS-PCR technique was used to investigate the single nucleotide polymorphism (SNP) from the AQP-2, genes. The result of this study investigated that SNP rs3759126 located in AQP-2 is a significant association with hypertension and CKD.
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