The role maternal toxoplasmosis in the development of autism disease in Al-Diwaniyah governorate, Iraq
Keywords:
autism, Toxoplasmosis, mtDNA, mutation, maternalAbstract
The study aimed to investigate the role of Toxoplasma gondii in causing autism and included 100 autistic patients from different governorates for the period from January to June of the year 2022. The results of the serological analysis showed that 8 of them were infected with toxoplasmosis by 8%, The results of the statistical analysis showed that there were no clear significant differences between the number of autistic patients with toxoplasmosis and their areas of residence at the level of probability (P > 0.05). Genetic variation (mutation analysis) was found in human mitochondrial CoxI gene among autistic patients, NCBI reference samples from one or two mutations, and the total percentage of genetic variation ranged from 2.08-1.04% , while genetic variation (mutation analysis) was found in The human mitochondrial gene Nad1 between autistic patients, healthy subjects and NCBI-Genbank reference samples had from one to two mutations in a proportion of total genetic variance that ranged 1.3-2%.
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References
Abdoli A, Dalimi A. Are there any relationships between latent Toxoplasma gondii infection, testosterone elevation, and risk of autism spectrum disorder? Front Behav Neurosci 2014; 8:339.
Akouchekian M, Hakim Shooshtari M, Heidary H, Zahedi Abghari F, Moeinian P. The causative variants of amyloidosis in the autism. Int. J. Neurosci. 2019;129(1):10–5.
Al Maliki Jamilla 5. Al Malk, Nahed Ahmed Hussien and Fuad: Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies 2021 21:133 https://doi.org/10.1186/s12887-021-02604-4
Al-Gharibawi, Y. K., & Alwaaly, A. B. (2021). Pregnant Women With Toxoplasmosis In Al-Hai City, Wasit Governorate, Iraq. NVEO-NATURAL VOLATILES & ESSENTIAL OILS Journal| NVEO, 5431-5440.
Berrebi, A. B, M. and Bessieres, M (2007): Outcome for children infected with congenital toxoplasmosis in the first trimester and with normal ultrasound finding: a study of 36 cases. Eur. Obst. Gynecol. Rep. Bio. J.135:53-57
Bushra Azizi, Najma Hamid , Hussein Hamidi Najat 2019,Relationship between Toxoplasma gondii contamination and autistic disorder in children Department of Clinical Psychology, College of Educational Sciences and Psychology, Shahid Chamran University of Ahvas, Ahvas, Iran Department of Pathology, College of Veterinary Medicine, Shahid Chamran University of Ahvas, Ahvas, Iran 10.22059 JFR. 2019.252512.2764 Receipt date: April 22, 2010 Acceptance date: July 4, 2010
Esnafoglu,Erman Esra Yancar Demir, Yeliz Cetinkol Mustafa Kerem Calgin Abdullah Erdi Emine Yurdakul Erturk Abdullah Dagli(2017) :The Seroprevalence of Antibodies to Toxoplasma Gondii Among Children with Autism Ordu University, Faculty of Medicine, Training and Research Dusunen Adam The Journal of Psychiatry and Neurological Sciences 2017,30,309315 DOL 10:5350/DAJPN2017300404
Ghazal Magdy Fath. (2007). Active in a skills development training program Sociology of a type of self-care for autistic children in the city of Amman. Master's thesis. University of Jordan publication.
Grether JK, Croen LA, Anderson MC, Nelson KB, Yolken RH. Neonatally measured immunoglobulins and risk of autism. Autism Res.2010;3(6):323– 32. https://doi.org/10.1002/aur.160.
Gu F, Chauhan V, Kaur K, Brown WT, La Fauci G, Wegiel J, et al. Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism. Transl Psychiatry. 2013; 3:3:e299.
Hajsoleimani F, Atarian A, Nourian A. Mazloomzades S. Seroprevalence of Toxoplasma gondii in pregnant women and bioassay of IgM positive cases in Zanjan, Northwest of Iran Iran J Parasitol. 2012;7(2):82-6. PMID:23109950
Hodková H, Kolbeková P, Skallová A, Lindová J, Flegr J. Higher perceived dominance in Toxoplasma infected men- a new evidence for role of increased level of testosterone in toxoplasmosis-associated changes in human behavior. Neuro Endocrinol Lett 2007; 28:110-114.
Jamila S. Al Malki1, Nahed Ahmed Hussien1* and Fuad Al Malki2 : Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies . Malki et al. BMC Pediatrics (2021) 21:133 https://doi.org/10.1186/s12887-021-02604-4
Najmat Hamid, Bushra Azizi, Hussein Hamidi Najat 2019. Investigation of Toxoplasma gondii parasite infection and aggression in children with autistic disorder and normal Associate Professor, Department of Clinical Psychology, College of Psychology and Educational Sciences, Shahid Chamran University of Ahvas, Ahvas, Iran Department of Pathology, College of Veterinary Medicine, Shahid Chamran University of Ahvas, Ahvas, Iran Research article (original article Volume 8 Issue 3 Summer, pp. 249 to 262 Accepted Date: 05/31/99 Received Date: 10/12/98
Ngô HM, Zhou Y, Lorenzi H, Wang K, Kim TK, Zhou Y, et al. Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer. Sci Rep. 2017;7(1):11496.
Nouri Al-Qamsh Al-Mustafa: Multiple Disabilities. The first edition, Dar Al Masirah for Publishing and Distribution, Amman / Jordan 2011
Pelloux, H.; Brun, E.; Vernet. G.; Marcillat. S. and Ambroise-Thomas, P. (1998). Determination of anti- Toxoplasma gondii immunoglobulin G avidity. Diagn. Microbiol. Infect. Dis., V. (32): Pp.69-73
Prandota J. Autism spectrum disorders may be due to cerebral toxoplasmosis associated with chronic neuroinflammation causing persistent hypercytokinemia that resulted in an increased lipid peroxidation, oxidative stress, and depressed metabolism of endogenous and exogenous substances. Res Autism Spectr Disord. 2010;4(2):119–55.
Simister, N. E. (2003). Placental transport of immunoglobulin G. Vaccine 21, 3365-3369. doi: 10.1016/S0264-410X(03)00334-7.
Spann MN, Sourander A, Surcel HM, Hinkka-Yli-Salomäki S, Brown AS. Prenatal toxoplasmosis antibody and childhood autism. AutismRes.2017;10(5):769–77. https://doi.org/10.1002 /aur.1722.
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