A study on sarcoidosis with clinical profile, diagnosis and treatment
A clinic’s perspective
Keywords:
Sarcoidosis, Granuloma, Mediastinal adenopathy, Micronodules on HRCT, Multi system diseaseAbstract
Background: Sarcoidosis is a multisystem granulomatous disease of unknown etiology and a close mimic of Tuberculosis in TB endemic are as which poses a diagnostic challenge. Objective: The main objective of the study is to determine the prevalence of Sarcoidosis with respect to its clinical profile, diagnosis and treatment. Methodology: The present study is a descriptive study with20 documented cases of Sarcoidosis from South India; the study span was from 2011 to 2021with Particular reference to cardiac and other organ involvement. Results: The results showed pulmonary involvement in 100% of patients followed by peripheral Lymph nodal involvement in 70% of patients which offered easy and cost effective diagnosis .Cardiac involvement was noted in 15% of patients as against scarce case reports from India. Ocular and Cutaneous involvement was seen in 15% of patients each. Kidneys and Parotids were involved in 5% of Patients. It should be suspected in any patient with appropriate clinical/radiological findings and the diagnosis of non-caseating granuloma should be made from an easily accessible peripheral site, followed by bronchoscopic and other methods. It should be differentiated from Tuberculosis and other granulomatous lesions. It is a steroid responsive condition and carries good prognosis.
Downloads
References
Arkema EV ,Grunevald J. Sarcoidosis incidence and prevalence , a nationwide register- based assessment in Sweden. EURResp2016;48(6):1690-1699.
Baughman RP, Field S. Sarcoidosis in America: analysis based on health care use. Ann Aam Thoracic soc 2016;13(8):244-1252.
BaughmanRP,Tierstein et al. A case control etiologic study of Sarcoidosis(ACCESS)Research group: clinicalcharacteristics of patients in a case control study of sarcoidosis Am J JRespi. Criti.Med2001;164(10,pt 1)1885-1889.
Caliskan C, Prasse A. Treating Sarcoidosis and potential new drugs. ERS Monograph.2022:328-336.
David Birnie,Andrew C.T; Cardiac Sarcoidosis , Clinics in Chest Medicine,Dec 2015 ,vol 36,pg 657-668.
HamzehNY ,Weinberger HD ,Management of cardiac sarcoidosis in the united states, a Delphi study. Chest 2012;141(1),154-162.
Karan M, PB Sryma PB. Clinical Profile of 327 patients with Sarcoidosis in India: An Ambispective Cohort Study in a Tuberculosis (TB) endemic population. Lung India2022;39:51-7.
KassirerJP.Our stubborn quest for diagnostic certainty.A cause of excessive testing.N Engl J Med 1989; 320:1489-91.
Nagai S ,Yokomatsuet al Treatment with low dose corticosteroid and Methotrexate in Sarcoidosis patients with cardiac lesions. Inter med 2014;53(5)427-433.
Pasadhika S Rosenbaum JT .Ocularsarcoidosiscliche med 2015;36(4);669-683..
PatompongUngprasert Jay H, Matteson et al. Clinical Manifestations, Diagnosis,and Treatment of Sarcoidosis,Mayo cli proc inn qual 2019;3(3)358-375.
Raj Kumar. Sarcoidosis North Indian Population : a retrospective study, V P Chest Institute, Chest Dis Allied Sci 2012;54-99-104.
Remy-Jardin M. Pulmonary sarcoidosis :role of CT in the evaluation of Disease activity and functional impairment and in prognosis assessment..Radiology 1994;191(3):675-80.
Talwar D, IyerH . Pulmonary Sarcoidosis. Indian J Rheumatol 2021;16:S47-57
Ungprasert P, Carmona EM. Epidemiology of Sarcoidosis 1946 –2013 ; a population based study. MayoCln proc 2016; 91(2):183-188
Valeyre D. ERS Clinical practice guidelines on treatment of sarcoidosis. Eur.Res J. 2021;58:2004079.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
