The association of baseline C-reactive protein and D-dimer levels with six-minute walk test in severe COVID-19 survivors

Pande Made Budi Wadanta; I Ketut Agus Somia; Ni Luh Putu Eka Arisanti; Ida Bagus Ngurah Rai; Ida Ayu Jasminarti Dwi Kusumawardani; Ni Wayan Candrawati; I Gusti Ngurah Bagus Artana

doi:10.53730/ijhs.v6nS8.12974

Authors

Pande Made Budi Wadanta Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah General Hospital, Bali, Indonesia, 80114
I Ketut Agus Somia Tropic Infection Division of Internal Medicine Department, Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah General Hospital, Bali, Indonesia, 80114
Ni Luh Putu Eka Arisanti
eka.arisanti@unud.ac.id
Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah General Hospital, Bali, Indonesia, 80114
Ida Bagus Ngurah Rai Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah General Hospital, Bali, Indonesia, 80114
Ida Ayu Jasminarti Dwi Kusumawardani Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah General Hospital, Bali, Indonesia, 80114
Ni Wayan Candrawati Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah General Hospital, Bali, Indonesia, 80114
I Gusti Ngurah Bagus Artana Department of Pulmonology and Respiration Medicine, Faculty of Medicine, Udayana University, Udayana University Hospital, Bali, Indonesia, 80361

Keywords:

CRP, d-dimer, 6MWT, severe COVID-19 survivors

Abstract

The post-COVID-19 syndrome can affect the patients' activities. The hyperinflammatory response resulting in permanent organ system damage or prolonged inflammation is thought to cause persistent symptoms. Inflammatory and coagulation markers C-reactive protein (CRP) and d-dimer may increase in acute phase of SARS-CoV-2 infection and associated with unexpected outcome. Therefore, the researcher wanted to assess the association of baseline CRP and d-dimer levels with the six-minute walk test (6MWT) in severe COVID-19 survivors. This is a cross-sectional, observational analytic study. A total 80 participants were included in this study. The proportion of subjects with poor results of 6MWT was 71.3%. Bivariate analysis of high baseline level of CRP and d-dimer, and age 65 years old on the 6MWT showed significant results, with prevalence ratio (PR) consecutively 1.8 (95% CI1.408-2.284;p= <0.001),1.4 (95% CI1.165-1.796;p=0.018) , and 1.5 (95% CI 1.287-1.831; p= 0.008). Based on multivariate analysis, only high baseline level of CRP was significant (PR = 1.8, 95% CI 1.051-3.136; p = 0.032). The proportion of severe COVID-19 survivors with poor 6MWT was high. There is a significant association between high baseline levels of CRP with a poor 6MWT in severe COVID-19 survivors.

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