Correlation between alveolar-arterial oxygen tension difference gradient baseline with spirometry test in severe coronavirus disease 2019 (COVID-19)

Ida Bagus Janantara Wirakusuma; I Ketut Agus Somia; Ni Luh Putu Eka Arisanti; Ida Bagus Ngurah Rai; Ida Ayu Jasminarti Dwi Kusumawardani; Ni Wayan Candrawati; I Gusti Ngurah Bagus Artana

doi:10.53730/ijhs.v6nS9.12986

Authors

Ida Bagus Janantara Wirakusuma Department of Pulmonology and Respiratory, Faculty of Medicine, Udayana University, Prof. Dr IGNG. Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
I Ketut Agus Somia
agus.somia@unud.ac.id
Department of internal medicine, Faculty of Medicine, Udayana University, Prof. Dr. IGNG. Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Ni Luh Putu Eka Arisanti Department of Pulmonology and Respiratory, Faculty of Medicine, Udayana University, Prof. Dr. IGNG. Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Ida Bagus Ngurah Rai Department of Pulmonology and Respiratory, Faculty of Medicine, Udayana University, Prof. Dr. IGNG. Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Ida Ayu Jasminarti Dwi Kusumawardani Department of Pulmonology and Respiratory, Faculty of Medicine, Udayana University, Prof. Dr. IGNG. Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Ni Wayan Candrawati Department of Pulmonology and Respiratory, Faculty of Medicine, Udayana University, Prof. Dr. IGNG. Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
I Gusti Ngurah Bagus Artana Department of Pulmonology and Respiratory, Faculty of Medicine, Udayana University, Prof. Dr. IGNG. Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114

Keywords:

AaDO2, Spirometry Test, Severe COVID-19 Survivors

Abstract

Alveolar-arterial Oxygen Tension Differences are one of the oxygenations that can increase SARS-CoV-2 virus infection. Based on this, the researchers wanted to assess the relationship between the baseline AaDO2 gradient and spirometry tests in severe COVID-19 survivors. This research is an observational analytic study with a cross-sectional design. The analysis was carried out in bivariate and multivariate tests assisted by using SPSS 26. The subjects who participated in the study were 80 people. Subjects with AaDO2 values > 39.4 mmHg 70% (n=56), median AaDO2 gradient was 60.45 (2.75 - 548.2 mmHg). The relationship between baseline AaDO2 analysis and spirometry results showed that it was associated with FVC and FEF25-75% results, respectively (PR) 18.6 (95% CI 3.978-87.401 p = <0.001) and (PR) 7.7 (95% CI 1.606-3.724 p = 0.011) and no significant with FEV1 and FEV1/FVC values. This study concludes a relationship between a high baseline AaDO2 gradient with FVC and FEF values of 25-75% in severe adult COVID-19 survivors. There was no relationship between a high baseline AaDO2 gradient and FEV1 and FEV1/FVC values.

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References

Albitar, O., Ballouze, R., Ooi, J.P. and Sheikh Ghadzi, S.M. (2020) ‘Risk factors for mortality among COVID-19 patients’, Diabetes Research and Clinical Practice, 166, p. 108293. Available at: https://doi.org/10.1016/j.diabres.2020.108293.

Bothe, K. (2021) ‘COVID-19: Compulsory vaccination for workers in the medical field?’, Deutsche Medizinische Wochenschrift, 146(13–14), pp. 933–935. Available at: https://doi.org/10.1055/a-1506-2458.

Brake, S.J., Barnsley, K., Lu, W., McAlinden, K.D., Eapen, M.S. and Sohal, S.S. (2020) ‘Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)’, Journal of clinical medicine, 9(3). Available at: https://doi.org/10.3390/JCM9030841.

Desai, A.D., Lavelle, M., Boursiquot, B.C. and Wan, E.Y. (2022) ‘Long-term complications of COVID-19’, American Journal of Physiology - Cell Physiology, 322(1), pp. C1–C11. Available at: https://doi.org/10.1152/AJPCELL.00375.2021.

Fisher, A.N. and Ryan, M.K. (2021) ‘Gender inequalities during COVID-19’, Group Processes and Intergroup Relations, 24(2), pp. 237–245. Available at: https://doi.org/10.1177/1368430220984248.

Gallo Marin, B., Aghagoli, G., Lavine, K., Yang, L., Siff, E.J., Chiang, S.S., Salazar-Mather, T.P., Dumenco, L., Savaria, M.C., Aung, S.N., Flanigan, T. and Michelow, I.C. (2021) ‘Predictors of COVID-19 severity: A literature review’, Reviews in Medical Virology, 31(1), pp. 1–10. Available at: https://doi.org/10.1002/rmv.2146.

Huang, I., Pranata, R., Lim, M.A., Oehadian, A. and Alisjahbana, B. (2020) ‘C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis’, Therapeutic Advances in Respiratory Disease, 14, pp. 1–14. Available at: https://doi.org/10.1177/1753466620937175.

Labarca, G., Henríquez-Beltrán, M., Lastra, J., Enos, D., Llerena, F., Cigarroa, I., Lamperti, L., Ormazabal, V., Ramirez, C., Espejo, E., Canales, N., Fuentes, F., Horta, G., Fernandez-Bussy, S. and Nova-Lamperti, E. (2021) ‘Analysis of clinical symptoms, radiological changes and pulmonary function data 4 months after COVID-19’, Clinical Respiratory Journal, 15(9), pp. 992–1002. Available at: https://doi.org/10.1111/crj.13403.

Moreno-pérez, O., Merino, E., Leon-ramirez, J., Andres, M., Manuel, J., Arenas-jiménez, J. and Asensio, S. (2021) ‘Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study’, Journal of Infection, 82(January), pp. 373–378.

Munker, D., Osterman, A., Muenchhoff, M., Stubble, H., Veit, T. and Weinberger, T. (2021) ‘Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients Dieter’, European Respiratory Journal, 75(10), p. 743. Available at: https://doi.org/10.1183/13993003.02724-2020.

Myall, K.J., Mukherjee, B., Castanheira, A.M., Lam, J.L., Benedetti, G., Mak, S.M., Preston, R., Thillai, M., Dewar, A., Molyneaux, P.L. and West, A.G. (2021) ‘Persistent post–COVID-19 interstitial lung disease: An observational study of corticosteroid treatment’, Annals of the American Thoracic Society, 18(5), pp. 799–806. Available at: https://doi.org/10.1513/AnnalsATS.202008-1002OC.

Pambudi, I.G.P.B, Suryana, I.K., Rai, I.B.N., Kusumawardani, I.A.J.D., Candrawati, N.W., Sajinadiyasa, I.G.K. (2022) ‘High Neutrophil to Lymphocyte Ratio, C-reactive Protein, Procalcitonin and D-dimer and Risk Faktors for Severe COVID-19’, Medico-legal Update, 22(1), pp. 41–46. Available at: http://www2.warwick.ac.uk/fac/sci/whri/research/mushroomresearch/mushroomquality/fungienvironment%0Ahttps://us.vwr.com/assetsvc/asset/en_US/id/16490607/contents%0Ahttp://www.hse.gov.uk/pubns/indg373hp.pdf.

R. Torres-Castro, L. Vasconcello-Castillo X. Alsina-Restoy, L. Solis-Navarro, F. Burgosc, H. Puppoa, J.V. (2021) ‘Respiratory function in patients post-infection by COVID-19’, Journal of Pulmonology, 27(27), pp. 328–337.

Rees, E.M., Nightingale, E.S., Jafari, Y., Waterlow, N.R., Clifford, S., Carl, C.A., Group, C.W., Jombart, T., Procter, S.R. and Knight, G.M. (2020) ‘COVID-19 length of hospital stay: A systematic review and data synthesis’, BMC Medicine, 18(1). Available at: https://doi.org/10.1186/s12916-020-01726-3.

Santus, P., Flor, N., Saad, M., Pini, S., Franceschi, E., Airoldi, A., Gaboardi, P., Ippolito, S., Rizzi, M. and Radovanovic, D. (2021) ‘Trends over time of lung function and radiological abnormalities in covid-19 pneumonia: A prospective, observational, cohort study’, Journal of Clinical Medicine, 10(5), pp. 1–17. Available at: https://doi.org/10.3390/jcm10051021.

Da Silva, A.L.O., Moreira, J.C. and Martins, S.R. (2020) ‘COVID-19 and smoking: a high-risk association’, Cadernos de saude publica, 36(5). Available at: https://doi.org/10.1590/0102-311X00072020.

Swenson, K.E. and Swenson, E.R. (2021) ‘Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury’, Critical Care Clinics, 37, pp. 749–776. Available at: https://doi.org/https://doi.org/10.1016/j.ccc.2021.05.003.

Visca, D., Ong, C.W.M., Tiberi, S., Centis, R., D’Ambrosio, L., Chen, B., Mueller, J., Mueller, P., Duarte, R., Dalcolmo, M., Sotgiu, G., Migliori, G.B. and Goletti, D. (2021) ‘Tuberculosis and COVID-19 interaction: A review of biological, clinical and public health effects’, Pulmonology, 27(2), pp. 151–165. Available at: https://doi.org/10.1016/j.pulmoe.2020.12.012.

Wang, D., Chukwu, A., Millogo, O., Assefa, N., James, C., Young, T., Lankoande, B., Workneh, F., Hemler, E.C., Korte, M.L., Mattei, J., Soura, A.B., Sie, A., Oduola, A., Berhane, Y. and Fawzi, W.W. (2021) ‘The COVID-19 pandemic and adolescents’ experience in sub-Saharan Africa: A cross-country study using a telephone survey’, American Journal of Tropical Medicine and Hygiene, 105(2), pp. 331–341. Available at: https://doi.org/10.4269/ajtmh.20-1620.