Assessment of antimicrobial drugs utilization in tertiary care hospital-an antimicrobial stewardship implication
Keywords:
Antimicrobial Stewardship (AMS), Prospective Audit and Feedback (PAF), Drug utilization evaluation (DUE), Anatomical therapeutic intervention (ATC), Defined daily dose (DDD)Abstract
Background: Irrational antibiotic usage major cause of spreading antimicrobial resistance therefore goal of this research was to refine prescribing patterns and may aid in addressing issues related to irrational antibiotic usage. Method: This prospective observational research was conducted at Maharishi Markandeshwar Institute of Medical Sciences & Research to assess the prescribing pattern of Antimicrobials Agents (AMAs) as well as the logic of their use. Results: The study enlisted the participation of 100 individuals. Of all 63% were male and 37% were female. The vast majority of participants are between the ages of 41- 60.94% of the 100 subjects receive AMAs.In our study, cephalosporins and β-lactams were found to be the most widely used AMA class (52.6%).Ceftriaxone was prescribed the most (32%), followed by piperacillin and tazobactam (23%).Antibiotics were given to patients for a maximum period up to 7 days in 39% and 5% of patients were given more than 17 days. 59 % patient’s urine sample was collected AST from different sites, urine (30), pus and sputum (7), blood (5), wound and et (3), pleural (1), ascitic (1), AFB (1), and abdominal (1).Only 37.8% specimens yielded a positive result, whereas 62.71% yielded a negative result Conclusion.
Downloads
References
Mohanraj R, Suvarchala S, Ramkesava R, Padmanabha R. Drug use evaluation of antimicrobials in healthcare resource-limited settings of india. Indian J of Pharm Pract.2015; 4(8):191-95.
Lellanand MC, Gray J. The rational use of antibiotics in bacterial infection. Current paediatrics.2001; 11(6):438-44.
Smita D, Debasis R. A study on antimicrobial agents utilization pattern using anatomical therapeutic chemical / daily defined dose system and adverse drug reaction pattern in the intensive care unit of a tertiary care teaching hospital in North Eastern state of India. Int J Basic Clin Pharmacol.2018;7(8):1612-19
Pandiamunian J, Somasundaram G. A study on prescribing pattern of anti microbial agents in the medical intensive care unit of a tertiary care teaching hospital in puducherry union territory, south india. Int J Pharm Pharm Sci. 2014; 6(3):235-8.
Raju R, Kuruvilla A, Ramesh M. Assessment of Antibiotic Utilization Pattern In Hospital Settings, Int. J. Pharm. Sci. Res.2020; 11(3):4277-4282.
Mohammadi M, Mirrahimi B, Mousavi S, Moradi M. Drug use evaluation of three widely prescribed antibiotics in a teaching hospital in east of iran. J Pharm Care. 2013; 3:100-3.
Al-Balushi K, Al-Ghafri F, Al-Sawafi F, Al-Zakwani I. Antibiotic prescribing trends in an omani paediatric population. Sultan QaboosUniv Med J. 2014;14(4):e495-9
Drug use evaluation (DUE) (drug utilization review), 2015. Available at: http://www.apps.who.int/medicinedocs/en/d/ Js4882e/8.5.html. Accessed 01 March 2015.
Salehifar E, Babamahmoodi F, Alikhani A, Ganji R, Fazli M. Drug utilization evaluation of vancomycin in a referral infectious center in mazandaran province. J Pharm Care. 2014; 2:55-9.
Biru TT, Defersha AD, Gelaw BK, Tegegne GT. Drug utilization review of ciprofloxacin in the outpatient department of borumeda hospital, south wollo zone, amhara Region, Ethiopia. Int J Basic ClinPharmacol. 2014; 3:171-8.
Beg MA, Bawa S, Anjoom M, Vishal S, Study of antimicrobial prescribing pattern in a tertiary care teaching hospital at Dehradun, Uttarakhand, India - A tool to teach clinical pharmacology to MBBS students, International Journal of Basic & Clinical Pharmacology 2016; 5(6):2444-2448.
Bithi S, Khan MR, Khan AU, Drug utilization study in orthopaedic units: Antibiotics prescribed in hospital outpatients in Dhaka, Bangladesh, International Current Pharmaceutical Journal, 2014; 3(9):318-321
Randad RD, Bhagwate ST, Mohd. Khalid Inamdar MK, Drug utilization study of some antibiotic in indoor setting at tertiary care teaching hospital in Central India: a descriptive study, International Journal of Basic & Clinical Pharmacology, 2017; 6(5):1123-1126.
Russell A D. Types of antibiotics and synthetic antimicrobial agents. In: Denyer SP., Hodges N A. & German SP. (eds.) Hugo and Russell‟s pharmaceutical microbiology. 7th Ed. Blackwell Science, UK, 2004; 152-186.
Denyer SP, Hodges NA, German SP. Introduction to pharmaceutical microbiology. In: Denyer SP, Hodges NA & German SP (eds.) Hugo and Russell‟s Pharmaceutical Microbiology. 7th Ed. Blackwell Science, UK, 2044; Pp. 3-8.
Schlegel H. General microbiology. 7th Ed. Cambridge University Press, Cambridge; 2003
Walsh C. Antibiotics: actions, origins, resistance. 1st Ed. ASM Press, Washington, DC. 2003; 345
Brooks GF, Butel JS, Morse SA. Melnick J, Adelberg‟s Medical Microbiology, 23rd Edition. McGraw Hill Companies, Singapore; 2004
Bansal D, Mangala S, Undela K, Gudula K, D’cruse S, Sachdev A, et al. Measurement of Adult Antimicrobial Drug Use in Tertiary Care Hospital Using Defined Daily Dose and Days of Therapy. Indian J PharmaceuScien. 2014;76(3):211-7.
Shaw PM, Gayman JE and Todd MW. ASHP Guidelines on medication-use evaluation. Am. J. Health Syst. Pharm. (1996) 53: 1953-5.
Stolar M. Drug use review: operational defenitions. Am. J. Hosp. Pharm. (1978) 33: 225-230.
Patel SR, Shah AM, Shah RB, Buch JG. Evaluation of drug utilization pattern of antimicrobials using ATC / DDD system in intensive care unit of a tertiary- care teaching hospital. Inte J Med Scien and PubliHealt. 2016;5(1):80-4.
WHO Collaborating Centre for Drug Statistics Methodology. ATC Index with DDDs. Oslo: WHO Collaborating Centre for Drug Statistics Methodology, 2002
Anand N, Nayak IMN, Advaitha MV, Thaikattil NJ, Kantanavar KA, Anand S. Ind J Criti Care Medici. 2016; 20(5):22-7.
Alamchandani RR, Khubchandani PR. A Study Evaluating Appropriateness of Utilization Pattern of Antimicrobials in Patients Admitted in Medical Intensive care unit of Tertiary Care Teaching Rural Hospital. Int J Pharm Pharm Sci. 2015;7(5):101-4.
Patanaik SK, Pattanayak C, Prasad A, Chauhan AS. Drug Utilization Pattern in an Intensive Care Unit Setting in Eastern India. Int J Basic ClinPharmacol. 2015;4(6):1136-41.
Shelat PR, Gandhi AM, Patel PP. A Study of ine Dose in Drug Utilization Pattern According to Daily Define Dose in Intensive Care Unit (ICU) at Tertiary Care Teaching Hospital, India. J You Pharmacis. 2015;7(4):349-58.
O'Donnell JN, Rhodes NJ, Miglis CM, et.al. Impact of early antimicrobial stewardship intervention in patients with positive blood cultures: results from a randomized comparative study. Int J Antimicrob Agents. 2022 Feb; 59(2):106490.
Shamshy K, Mufida BL, Perumal P. Drug utilization of antimicrobial drug in paediatrics population in a tertiary care hospital in erode, tamil nadu, india. International Journal of PharmTech Research CODEN (USA). 2011;3(3):1530-6.
Williams A, Mathai AS, Phillips AS. Antibiotic prescription patterns at admission into a tertiary level intensive care unit in Northern India. J Pharm Bioallied Sci. 2011;3:531 6.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.