Pharmaceutical approaches towards design and development of microsponges containing etodolac

Authors

  • Ajeet Singh Department of Pharmaceutical Sciences, J.S. University, Mainpuri Road, Shikohabad, Firozabad, U.P, India-283135
  • Anuj Malik MM college of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, Ambala, 133203. India
  • A Kishore Babu Department of Pharmaceutics, School of pharmacy, Raffles University, Neemrana, Rajasthan 301705
  • M Pradeep Kumar Department of Pharmaceutics, Vasavi Institute of Pharmaceutical Sciences Kadapa-516247
  • Kotaiah Silakabattini Department of Pharmacognosy, Indira College of Pharmacy, Vishnupuri, Nanded- 431606
  • Gaurav Tiwari PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kalpi Road, Bhauti, Kanpur, India
  • Ajay Kumar Gupta University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University (formerly Kanpur University), Kanpur-208024, Uttar Pradesh, India
  • G. Hema Department of Biotechnology, School of Sciences, Maharani Cluster University, Palace Road, Bangalore, Karnataka 560001
  • Shikha Yadav School of Medical and Allied Science (Pharmacy Department), Galgotias University, Yamuna Expressway, Sector 17A, Greater Noida, U.P., India-203201
  • Ruchi Tiwari PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kalpi Road, Bhauti, Kanpur, India

Keywords:

micrsponges, microsponge delivery system, eudragit (RS100), etodolac, controlled drug delivery system

Abstract

The goal of the present study was to develop and evaluate microsponge-based gelatin Capsule for oral delivery system of Etodolac for controlled release and enhanced bioavailability and solubility of insoluble drug. Microsponges containing Etodolac were prepared by a Quasi-emulsion solvent diffusion method. The effect of formulation and process variables such as, polymer ratio and stirring speed on the physical characteristics of microsponges were examined on optimized drug/polymer ratio. The optimized microsponges were incorporated into a gelatin capsule shell. In vitro drug release studies were carried out. Capsules containing microsponges showed desired physical properties. The effects of drug to polymer ratios on physical characteristics of the microsponges were investigated. Thermal behavior, surface morphology, particle size and pore structure of the microsponges were examined. In-vitro drug release rate from the microsponges was also investigated. In-vitro dissolution study showed that the release rate of the dug has been modified. This study presents a new approach based on microsponges for colon specific drug delivery. The sizes of microsponges were found to be uniform and in the shape. The Infrared (IR) spectral analysis suggested that there was no interaction between the drug and formulation polymer. 

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Published

19-10-2022

How to Cite

Singh, A., Malik, A., Babu, A. K., Kumar, M. P., Silakabattini, K., Tiwari, G., Gupta, A. K., Hema, G., Yadav, S., & Tiwari, R. (2022). Pharmaceutical approaches towards design and development of microsponges containing etodolac. International Journal of Health Sciences, 6(S8), 5415–5430. Retrieved from https://sciencescholar.us/journal/index.php/ijhs/article/view/13471

Issue

Vol. 6 No. S8 (2022)

Section

Peer Review Articles
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