Evaluation the role of CD34 in patients with acute myeloid leukemia

Hind Salih Muhammid; Alaa Jawad Hassan; Hussein Naji Abdulla

doi:10.53730/ijhs.v6nS9.13330

Authors

Hind Salih Muhammid
hindalhamdani2020@gmail.com
University of Babylon, College of Sciences, Dept. of Biology
Alaa Jawad Hassan University of Babylon, College of Sciences, Dept. of Biology
Hussein Naji Abdulla University of Babylon, College of Medicine, Al Hillah, Babil

Keywords:

Acute myeloid leukemia, CD34, blood parameters

Abstract

Acute myeloid leukemia (AML) is the most common leukemia among the adult population and accounts for about 80% of all cases, and its characterized by clonal expansion of immature “blast cells” in the peripheral blood and bone marrow. The stem cell marker CD34 is expressed by leukemia blasts only for a subset of patients with acute myelogenous leukemia (AML). The aim of this study is to determine the role of CD34 in AML and its relationship with the parameters of complete blood (CBC). A total of (60) venous blood sample from patients and (30) control their ages ranged between 18 and 66 years, the samples was collected from Baghdad medical city hospital. Sera from all participants were tested to assessment CD34 level by ELISA. In the current study, CD34 in patients and control groups show a significant difference in relation with AML patients at p-value (<0.001). The levels of CD34 in the patients were 0.55 ± 0.03, whereas it's significantly increased to 0.81 ± 0.05 in the control. Also we found the majority of patients presented with subtype M3 38.3% of total patients.

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