Apolipoprotein B level in corona virus patients in Iraq

Huda Falah Judi; Muntadher Mohammad Ali; Ahmed Ridha Abduljawad

doi:10.53730/ijhs.v6nS8.13529

Authors

Huda Falah Judi Department of Chemistry, College of Science, University of Kufa, Iraq
Muntadher Mohammad Ali
muntadhar.aljalal@uokufa.edu.iq
Department of Chemistry, College of Science, University of Kufa, Iraq
Ahmed Ridha Abduljawad Department of Chemistry, College of Science, University of Kufa, Iraq

Keywords:

COVID-19, SARS-CoV-2, fibrinogen, apolipoprotein, vitamin C

Abstract

Background: Since the outbreak of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, it has affected >200 countries, areas, or territories in 6 continents. At present, whether COVID-19 has an effect on thyroid function is unclear. The aim of this study was to evaluate Apolipoprotein in iraqi patients with COVID-19. Methods: Clinical features, laboratory results, and real time PCR were reviewed for 60 patients with laboratory-confirmed COVID-19. They were admitted to the Al-Sadr Teaching Hospital; Iraq between September and December 2021. Healthy participants who underwent routine physical checkups and non-COVID-19 patients the study as the control group. Apolipoprotein B and Fibrinogen levels were determine and compared between the COVID-19 and control groups. Results: Fibrinogen protein B lower than the normal range of the patients with COVID-19 Compared to the control group. The levels of Apolipoprotein of the patients with COVID-19 were significantly lower than those of the healthy control group. The lower the Fg and ABOB levels were, with statistical significance (p <0.001). Conclusions The Changing fibrinogen and apolipoprotein B in the blood of people with Coronavirus may have a role in the infection and the life cycle of the virus.

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References

Azkur, Ahmet Kursat, Mübeccel Akdis, Dilek Azkur, Milena Sokolowska, Willem van de Veen, Marie Charlotte Brüggen, Liam O’Mahony, Yadong Gao, Kari Nadeau, and Cezmi A. Akdis. 2020. “Immune Response to SARS-CoV-2 and Mechanisms of Immunopathological Changes in COVID-19.” Allergy: European Journal of Allergy and Clinical Immunology. Blackwell Publishing Ltd. https://doi.org/10.1111/all.14364.

Carpenè, Giovanni, Davide Negrini, Brandon M. Henry, Martina Montagnana, and Giuseppe Lippi. 2022. “Homocysteine in Coronavirus Disease (COVID-19): A Systematic Literature Review.” Diagnosis 0 (0). https://doi.org/10.1515/dx-2022-0042.

Chrysant, Steven G., and George S. Chrysant. 2018. “The Current Status of Homocysteine as a Risk Factor for Cardiovascular Disease: A Mini Review.” Expert Review of Cardiovascular Therapy. Taylor and Francis Ltd. https://doi.org/10.1080/14779072.2018.1497974.

Hou, Huimin, and Huiying Zhao. 2021. “Epigenetic Factors in Atherosclerosis: DNA Methylation, Folic Acid Metabolism, and Intestinal Microbiota.” Clinica Chimica Acta. Elsevier B.V. https://doi.org/10.1016/j.cca.2020.11.013.

Huang, Chaolin, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Yi Hu, Li Zhang, et al. 2020. “Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China.” The Lancet 395 (10223): 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5.

Koklesova, Lenka, Alena Mazurakova, Marek Samec, Kamil Biringer, Samson Mathews Samuel, Dietrich Büsselberg, Peter Kubatka, and Olga Golubnitschaja. 2021. “Homocysteine Metabolism as the Target for Predictive Medical Approach, Disease Prevention, Prognosis, and Treatments Tailored to the Person.” EPMA Journal. Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s13167-021-00263-0.

Kwok, See, Safwaan Adam, Jan Hoong Ho, Zohaib Iqbal, Peter Turkington, Salman Razvi, Carel W. le Roux, Handrean Soran, and Akheel A. Syed. 2020. “ Obesity: A Critical Risk Factor in the COVID ‐19 Pandemic .” Clinical Obesity 10 (6). https://doi.org/10.1111/cob.12403.

Lee J.I., Burckart G.J. Nuclear factor kappa B: important transcription factor and therapeutic target. J. Clin. Pharmacol. 1998;38(11):981–993.

Liu, Jing, Sumeng Li, Jia Liu, Boyun Liang, Xiaobei Wang, Hua Wang, Wei Li, et al. 2020. “Longitudinal Characteristics of Lymphocyte Responses and Cytokine Profiles in the Peripheral Blood of SARS-CoV-2 Infected Patients.” EBioMedicine 55 (May). https://doi.org/10.1016/j.ebiom.2020.102763.

Liu, Yen Chin, Rei Lin Kuo, and Shin Ru Shih. 2020. “COVID-19: The First Documented Coronavirus Pandemic in History.” Biomedical Journal. Elsevier B.V. https://doi.org/10.1016/j.bj.2020.04.007.

Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, et al. (2004). Vitamin C pharmacokinetics: implications for oral and intravenous use. Annals of Int Med, 140:533-537

Raghubeer, Shanel, and Tandi E. Matsha. 2021. “Methylenetetrahydrofolate (Mthfr), the One-Carbon Cycle, and Cardiovascular Risks.” Nutrients 13 (12). https://doi.org/10.3390/nu13124562.

Román, Gustavo C., Oscar Mancera-Páez, and Camilo Bernal. 2019. “Epigenetic Factors in Late-Onset Alzheimer’s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins.” International Journal of Molecular Sciences 20 (2). https://doi.org/10.3390/ijms20020319.

Singhal, Tanu. 2020. “A Review of Coronavirus Disease-2019 (COVID-19).” Indian Journal of Pediatrics. Springer. https://doi.org/10.1007/s12098-020-03263-6.

Smith, A. D., and H. Refsum. 2021. “Homocysteine – from Disease Biomarker to Disease Prevention.” Journal of Internal Medicine. John Wiley and Sons Inc. https://doi.org/10.1111/joim.13279.

Wang, Jinxiang, Dingyun You, Huaping Wang, Yanhong Yang, Dan Zhang, Junyan Lv, Sufeng Luo, Rui Liao, and Lanqing Ma. 2021. “Association between Homocysteine and Obesity: A Meta-Analysis.” Journal of Evidence-Based Medicine 14 (3): 208–17. https://doi.org/10.1111/jebm.12412.

Zhang L, Liu Y (2020). Potential interventions for novel coronavirus in China: A systematic review. J of Med Vir, 92:479-490.