Fibrinogen level in coronary artery disease people with COVID-19 patients in Iraq
Keywords:
COVID-19, SARS-CoV-2, Homocysteine, Fibrinogen, Coronary artery diseaseAbstract
Background: Since the outbreak of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, it has affected >200 countries, areas, or territories in 6 continents. At present, whether COVID-19 has an effect on cardiovascular system is unclear. The aim of this study was to evaluate Fibrinogen level in iraqi patients with COVID-19 with Coronary artery disease. Methods: Clinical features, laboratory results, and real time PCR were reviewed for 30 patients with laboratory-confirmed COVID-19 without a history of Coronary artery disease and 30 patients with laboratory-confirmed COVID-19 with Coronary artery disease. They were admitted to the Al-amal Hospital for participating; Iraq between October 2021-April 2022. Healthy participants who underwent routine physical checkups and non-COVID-19 patients the study as the control group. Fibrinogen and Apolipoprotein B levels were determine and compared between the Coronary artery disease COVID-19 and control groups. Results: Fibrinogen higher than the normal range of the patients with Coronary artery disease COVID-19 Compared to the control group. The levels of D.dimer and Ferretin of the patients with Coronary artery disease COVID-19 were significantly higher than those of the healthy control group.
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AL-Kindi, S., & Zidar, D. A. (2022). COVID-lateral damage: cardiovascular manifestations of SARS-CoV-2 infection. Translational Research, 241, 25–40. https://doi.org/10.1016/j.trsl.2021.11.005
Bhat, R. A., Maqbool, S., Rathi, A., Manzoor Ali, S., Ali Ashraf Muhammad Hussenbocus, Y., Wentao, X., Qu, Y., Zhang, Y., Sun, Y., Fu, H.-X., Yun Wang, L., Dwivedi, A., Akhter Bhat, J., saqib Iqbal, R., Monowarul Islam, M., Tibrewal, A., & Gao, C. (2022.). The Effects of the SARS-CoV-2 Virus on the Cardiovascular System and Coagulation State Leading to Cardiovascular Diseases: A Narrative Review. INQUIRY: The Journal of Health Care Organization, Provision, and Financing, 59, 1–10. https://doi.org/10.1177/00469580221093442.
Chrysant, Steven G., and George S. Chrysant. 2018. “The Current Status of Homocysteine as a Risk Factor for Cardiovascular Disease: A Mini Review.” Expert Review of Cardiovascular Therapy. Taylor and Francis Ltd. https://doi.org/10.1080/14779072.2018.1497974.
Clark, R. D., Graham, J. M., Friez, M. J., Hoo, J. J., Jones, K. L., McKeown, C., ... & Stevenson, R. E. (2009). FG syndrome, an X-linked multiple congenital anomaly syndrome: the clinical phenotype and an algorithm for diagnostic testing. Genetics in Medicine, 11(11), 769-775.
Hou, Huimin, and Huiying Zhao. 2021. “Epigenetic Factors in Atherosclerosis: DNA Methylation, Folic Acid Metabolism, and Intestinal Microbiota.” Clinica Chimica Acta. Elsevier B.V. https://doi.org/10.1016/j.cca.2020.11.013.
Huang, -C ;, Chang, Y.-T. ;, Yu, Y.-J. ;, Wang, C.-H. ;, Wu, L.-K. ;, Liu, C.-Y. ;, Chiu, P.-H. ;, & Sun, S.-F. ; (2022). Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis. https://doi.org/10.3390/diagnostics12071678
Huang, Chaolin, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Yi Hu, Li Zhang, et al. 2020. “Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China.” The Lancet 395 (10223): 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5.
İlker Hayıroğlu, M., Çınar, T., & İlker Tekkeşin, A. (2020). Fibrinogen and D-dimer variances and anticoagulation recommendations in COVID-19: current literature review. REV ASSOC MED BRAS, 66(6), 842–848. https://doi.org/10.1590/1806-9282.66.6.842
Kwok, See, Safwaan Adam, Jan Hoong Ho, Zohaib Iqbal, Peter Turkington, Salman Razvi, Carel W. le Roux, Handrean Soran, and Akheel A. Syed. 2020. “ Obesity: A Critical Risk Factor in the COVID ‐19 Pandemic .” Clinical Obesity 10 (6). https://doi.org/10.1111/cob.12403.
Lee J.I., Burckart G.J. Nuclear factor kappa B: important transcription factor and therapeutic target. J. Clin. Pharmacol. 1998;38(11):981–993.
Liu, Jing, Sumeng Li, Jia Liu, Boyun Liang, Xiaobei Wang, Hua Wang, Wei Li, et al. 2020. “Longitudinal Characteristics of Lymphocyte Responses and Cytokine Profiles in the Peripheral Blood of SARS-CoV-2 Infected Patients.” EBioMedicine 55 (May). https://doi.org/10.1016/j.ebiom.2020.102763.
Liu, Yen Chin, Rei Lin Kuo, and Shin Ru Shih. 2020. “COVID-19: The First Documented Coronavirus Pandemic in History.” Biomedical Journal. Elsevier B.V. https://doi.org/10.1016/j.bj.2020.04.007.
Lymperopoulos, A., Surma, S., & Banach, M. (2021). Fibrinogen and Atherosclerotic Cardiovascular Diseases-Review of the Literature and Clinical Studies. https://doi.org/10.3390/ijms23010193
Singhal, Tanu. 2020. “A Review of Coronavirus Disease-2019 (COVID-19).” Indian Journal of Pediatrics. Springer. https://doi.org/10.1007/s12098-020-03263-6.
Sulimai, N. H., Brown, J., & Lominadze, D. (2022). Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects. Biomedicines, 10(7), 1712. https://doi.org/10.3390/biomedicines10071712
Ulloque-Badaracco, Alarcon-Braga, J. R. ;, Hernandez-Bustamante, E. A. ;, Al-Kassab-Córdova, E. A. ;, Mosquera-Rojas, A. ;, & Herrera-Añazco, S. H. ; (2022). Fibrinogen-to-Albumin Ratio and Blood Urea Nitrogen-to-Albumin Ratio in COVID-19 Patients: A Systematic Review and Meta-Analysis Juan. https://doi.org/10.3390/tropicalmed7080150
Vineis, P., Hartung, T., P Holly, J. M., Markram, H., P-a, F., A-k, K., Logette, E., Lorin, C., Favreau, C., Oshurko, E., Coggan, J. S., Casalegno, F., François Sy, M., Monney, C., Bertschy, M., Delattre, E., Fonta, P.-A., Krepl, J., Schmidt, S., … Kaufmann, A.-K. (2019). A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19. Frontiers in Public Health | Www.Frontiersin.Org, 1, 695139. https://doi.org/10.3389/fpubh.2021.695139
Wang, Jinxiang, Dingyun You, Huaping Wang, Yanhong Yang, Dan Zhang, Junyan Lv, Sufeng Luo, Rui Liao, and Lanqing Ma. 2021. “Association between Homocysteine and Obesity: A Meta-Analysis.” Journal of Evidence-Based Medicine 14 (3): 208–17. https://doi.org/10.1111/jebm.12412.
Zhang L, Liu Y (2020). Potential interventions for novel coronavirus in China: A systematic review. J of Med Vir, 92:479-490.
Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, et al. (2004). Vitamin C pharmacokinetics: implications for oral and intravenous use. Annals of Int Med, 140:533-537
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