Effectiveness of preemptive regime; buprenorphine or tramadol with lidocaine and isoflurane on smooth post-operative recovery in novel uterine surgical model
Keywords:
Preemptive regime, postoperative pain, Incision, animal surgical model, balance anesthesia, Righting reflex, pedal withdrawal reflexAbstract
Introduction: Preemptive regime is proven to be effective component of balance anesthesia referring to smooth postoperative recovery in animal surgical models. Nature and method of induction as well as maintenance of general anesthesia along with suitable preemptive regime with minimal side effects, are the essential elements of research these days in animal surgical model. Objective: To determine the efficacy of preemptive regime (buprenorphine or tramadol with lidocaine and isoflurane) on a rat uterine surgical model pertaining to smooth postoperative recovery. Method: In this experimental study, uterine surgery was performed on 21 female Sprague dawley rats after dividing them into three study groups, each group comprising of 7 rats. In group A (BG) 7 rats were administered buprenorphine +lidocaine along with general anesthesia. In group B (TG) tramadol+lidocaine was given, whereas in group C (SG), saline injection was given along with general anesthesia. Results: On comparison between three study groups, statistically significant variation was noted in heart rate at 1min and 10 mins (p value 0.02). Preemptive regime either tramadol or buprenorphine significantly reduced recovery timing (p< 0.001) along with pedal withdrawal reflex and righting reflex as compared to saline group (p < 0.001 and p< 0.001) respectively.
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