The presence of the vim-2 gene of Pseudomonas aeruginosa carbapenem resistance

Kadek Ayu Vigiawati; Ni Nyoman Sri Budayanti; Ida Sri Iswari

doi:10.53730/ijhs.v6nS10.13809

Authors

Kadek Ayu Vigiawati Clinical Microbiology Study Program Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Ni Nyoman Sri Budayanti Clinical Microbiology Study Program Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Ida Sri Iswari Clinical Microbiology Study Program Faculty of Medicine, Udayana University, Prof. Dr. IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114

Keywords:

antibiotics, carbapenem resistance, Pseudomonas aeruginosa, vim-2 genes

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that causes infection in immunocompromised patients. Pseudomonas aeruginosa can cause severe acute and chronic infections in patients on ventilators and patients with burns, surgery, diabetic foot ulcers, and catheterization. vim-2 gene distributes metallo-β-lactamase with a broad spectrum of substrates against penicillins, cephalosporins, cefamycins, and carbapenems. Therefore, an attractive drug target for the treatment of β-lactam-resistant infections. This study aims to know the presence of the vim-2 P. aeruginosa carbapenem resistance gene. Pseudomonas aeruginosa is the most common microorganism that causes infection in the community and hospitals. Resistance of P. aeruginosa to various antibiotics is an increasingly common overuse or inappropriate use. vim-2 gene is of high clinical relevance due to its wide distribution and broad substrate range and therefore represents an important drug target for treating antibiotic-resistant infections. Based on the literature review, a molecular examination of the vim-2 gene is critical to be a reference in selecting appropriate antibiotics in addition to phenotypic study.

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References

CDC (2019) Antibiotic Resistance Threats In The United States 2019, Cdc. Available at: https://doi.org/10.1186/s13756-020-00872-w.

Centers for Disease Control and Prevention (2019) Pseudomonas aeruginosa in Healthcare Settings.

Christopeit, T., Yang, K.W., Yang, S.K. and Leiros, H.K.S. (2016) ‘The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor’, Acta Crystallographica Section:F Structural Biology Communications, 72(11), pp. 813–819. Available at: https://doi.org/10.1107/S2053230X16016113.

Crone, S., Vives-Flórez, M., Kvich, L., Saunders, A.M., Malone, M., Nicolaisen, M.H., Martínez-García, E., Rojas-Acosta, C., Catalina Gomez-Puerto, M., Calum, H., Whiteley, M., Kolter, R. and Bjarnsholt, T. (2020) ‘The environmental occurrence of Pseudomonas aeruginosa’, Apmis, 128(3), pp. 220–231. Available at: https://doi.org/10.1111/apm.13010.

Glen, K.A. and Lamont, I.L. (2021) ‘β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects’, Pathogens, 10(12). Available at: https://doi.org/10.3390/pathogens10121638.

Hong, D.J., Bae, I.K., Jang, I.H., Jeong, S.H., Kang, H.K. and Lee, K. (2015) ‘Epidemiology and characteristics of metallo-ß-lactamase-producing Pseudomonas aeruginosa’, Infection and Chemotherapy, 47(2), pp. 81–97. Available at: https://doi.org/10.3947/ic.2015.47.2.81.

Kakoullis, L. (2021) ‘Mechanisms of Antibiotic Resistance in Important Gram-Positive and Gram-Negative Pathogens and Novel Antibiotic Solutions’, Antibiotic Resistance, pp. 263–276. Available at: https://doi.org/10.3390/ antibiotics10040415 Academic10.1128/9781555815554.ch14.

Kateete, D.P., Nakanjako, R., Namugenyi, J., Erume, J., Joloba, M.L. and Najjuka, C.F. (2016) ‘Carbapenem resistant Pseudomonas aeruginosa and Acinetobacter baumannii at Mulago Hospital in Kampala, Uganda (2007–2009)’, SpringerPlus, 5(1). Available at: https://doi.org/10.1186/s40064-016-2986-7.

Lameng, I.S.V., Budayanti, N.N.S., Prilandari, L.I. and Adhiputra, I.K.A.I. (2021) ‘Antimicrobial Resistance Profile of MDR & Non-MDR Meropenem-Resistant Pseudomonas aeruginosa Isolates of Patients in Intensive Care Unit of Tertiary Hospital’, Indonesian Journal of Tropical and Infectious Disease, 9(3), p. 152. Available at: https://doi.org/10.20473/ijtid.v9i3.30000.

Lister, P.D., Wolter, D.J. and Hanson, N.D. (2009) ‘Antibacterial-resistant Pseudomonas aeruginosa: Clinical impact and complex regulation of chromosomally encoded resistance mechanisms’, Clinical Microbiology Reviews, 22(4), pp. 582–610. Available at: https://doi.org/10.1128/CMR.00040-09.

Mahon, C.R. (2019) media: Textbook of Diagnostic Microbiology, Laboratory Medicine. Available at: https://doi.org/10.1309/u0mb-0p7r-rrwf-4bth.

Mahon, C.R. and Lehman, D.C. (2016) Textbook of diagnostic microbiology.

Matsumura, Y., Peirano, G., Devinney, R., Bradford, P.A., Motyl, M.R., Adams, M.D., Chen, L., Kreiswirth, B. and Pitout, J.D.D. (2017) ‘Genomic epidemiology of global VIM-producing Enterobacteriaceae’, Journal of Antimicrobial Chemotherapy, 72(8), pp. 2249–2258. Available at: https://doi.org/10.1093/jac/dkx148.

Nathwani, D., Raman, G., Sulham, K., Gavaghan, M. and Menon, V. (2014) 'Clinical and economic consequences of hospital-acquired resistant and multidrug-resistant Pseudomonas aeruginosa infections: A systematic review and meta-analysis, Antimicrobial Resistance and Infection Control, 3(1). Available at: https://doi.org/10.1186/2047-2994-3-32.

Newman, J.W., Floyd, R. V. and Fothergill, J.L. (2017) 'The contribution of Pseudomonas aeruginosa virulence factors and host factors in the establishment of urinary tract infections, FEMS Microbiology Letters, 364(15), pp. 1–11. Available at: https://doi.org/10.1093/femsle/fnx124.

Poirel, L., Naas, T., Nicolas, D., Collet, L., Bellais, S., Cavallo, J.D. and Nordmann, P. (2000) 'Characterization of VIM-2, a carbapenem-hydrolyzing Metallo-β-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France', Antimicrobial Agents and Chemotherapy, 44(4), pp. 891–897. Available at: https://doi.org/10.1128/AAC.44.4.891-897.2000.

Rezaei, A., Fazeli, H., Balaji, M., Moghadampour, M. and Faghri, J. (2018) 'Prevalence of Metallo-beta-lactamase producing Acinetobacter baumannii isolated from intensive care unit in tertiary care hospitals, Annali di Igiene Medicina Preventiva e di Comunita, 30(4), pp. 330–336. Available at: https://doi.org/10.7416/ai.2018.2224.

Ruppé, É., Woerther, P.L. and Barbier, F. (2015) ‘Mechanisms of antimicrobial resistance in Gram-negative bacilli’, Annals of Intensive Care, 5(1). Available at: https://doi.org/10.1186/s13613-015-0061-0.

Ryan, K.J. (2019) Antibacterial Agents and Drug Resistance, Sherris Medical MicrobiologyI. Available at: https://doi.org/10.1007/978-3-319-99921-0_4.

Sanglah, R. (2021) Pola Kepekaan Mikroorganisme RSUP Sanglah Tahun 2021.

Tille, P. (2013) Bailey & Scott’s Diagnostic Microbiology.

Walters, M.S., Grass, J.E., Bulens, S.N., Hancock, E.B., Phipps, E.C., Muleta, D., Mounsey, J., Kainer, M.A., Concannon, C., Dumyati, G., Bower, C., Jacob, J., Cassidy, P.M., Beldavs, Z., Culbreath, K., Phillips., W.E., Hardy, D.J., Vargas, R.L., Oettinger, M., Ansari, U., Stanton, R., Albrecht, V., Halpin, A.L., Karlsson, M., Rasheed, J.K. and Kallen, A. (2019) 'Carbapenem-resistant pseudomonas aeruginosa at us emerging infections program sites, 2015', Emerging Infectious Diseases, 25(7), pp. 1281–1288. Available at: https://doi.org/10.3201/eid2507.181200.

Yoon, E.J. and Jeong, S.H. (2021) ‘Mobile Carbapenemase Genes in Pseudomonas aeruginosa’, Frontiers in Microbiology, 12(February). Available at: https://doi.org/10.3389/fmicb.2021.614058.

Zafer, M.M., Al-Agamy, M.H., El-Mahallawy, H.A., Amin, M.A. and El Din Ashour, S. (2015) ‘Dissemination of VIM-2 producing Pseudomonas aeruginosa ST233 at tertiary care hospitals in Egypt’, BMC Infectious Diseases, 15(1), pp. 1–7. Available at: https://doi.org/10.1186/s12879-015-0861-8.