High neutrophil-lymphocyte ratio as a predictor of mortality in major burn patients

Anak Agung Ngurah Gde Hendra Prayoga Setiawan; I Gusti Putu Hendra Sanjaya; Sianny Herawati; I Made Suka Adnyana; Agus Roy Rusly Hariantana Hamid; Ni Nyoman Sri Budayanti

doi:10.53730/ijhs.v6nS8.13029

Authors

Anak Agung Ngurah Gde Hendra Prayoga Setiawan
hendraprayogas@gmail.com
Resident at Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Udayana University, Prof. Dr IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
I Gusti Putu Hendra Sanjaya Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Udayana University, Prof. Dr IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Sianny Herawati Department of Clinical Pathology, Faculty of Medicine, Udayana University, Prof. Dr IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
I Made Suka Adnyana Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Udayana University, Prof. Dr IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Agus Roy Rusly Hariantana Hamid Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Udayana University, Prof. Dr IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114
Ni Nyoman Sri Budayanti Department of Clinical Microbiology, Faculty of Medicine, Udayana University, Prof. Dr IGNG Ngoerah Central General Hospital Denpasar, Bali, Indonesia, 80114

Keywords:

major burns, neutrophil-lymphocyte ratio, mortality, predictor

Abstract

Major burns are a type of trauma with high mortality risk. Therefore, an accurate predictor of mortality indicators is needed in burn patients. This study used an analytical observational study design with a retrospective case-control approach. One such indicator is the neutrophil-lymphocyte ratio which was studied further in this study. Subjects included 60 burn patients with 30 survivors and 30 mortalities. The sex characteristics of the subjects were predominantly male (70%), with a median age of 38.5 (IQR 30.5 – 52.5) years. Fire (68.3%) was the most common cause of burns. The median neutrophil-lymphocyte ratio decreased from day 1 (median 15.6, IQR 10.1–21.7) to day 3 (median 6.7, IQR 4.4 – 11.8). However, there was a different pattern in which the value of the neutrophil-lymphocyte ratio was found to increase on day 3 in the mortality group. The binomial logistic regression test found that the neutrophil-lymphocyte ratio value greater than or equal to 10 on the 3rd day was significantly associated with mortality risk with an aOR of 13.91 (95% CI 1.77 – 109.47). The conclusion is that A high neutrophil-lymphocyte ratio at day three can be used as a predictor of mortality in major burn patients.

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