Prevalence, serotypes, and third generation antibiotic-resistant patterns of Salmonella enteric serotype Typhi, in Peshawar

Authors

  • Aisha Gohar Demonstrator, Department of Pathology, Bacha Khan Medical College, Mardan
  • Muhammad Adeel Alam Assistant Professor, Pharmacology department, Ayub Medical College Abbottabad
  • Erum Rehman Lecturer, Peshawar Medical college, Peshawar, Riphah International University, Islamabad
  • Hayat Ur Rehman Associate Professor, Department of Paediatric Surgery, Qazi Husain Ahmad Medical Complex Nowshera
  • Sadia Aziz Department of Nephrology, University college of medicine and dentistry, Lahore, Pakistan

Keywords:

Salmonella, food-borne disease, antibiotics, multi-drug sensitivity

Abstract

Most of the major health problems are caused by Selmonella virus. This virus is recognized as the most common food born pathogen. We documented the participants' health conditions, including their demography, antibacterial sensitivity, and epigenetic changes for resistance to distinct Salmonella. Enterica variants, isolated here in 33 different strains of Salmonella Enterica were identified through biochemical characteristics and 16S recombinant deoxyribonucleic acid sequence. The most frequent bacterium, Salmonella Enterica Serovar Enteritidis, caused 39.4% of incidents, afterward, 21.2% were caused by Salmonella Paratyphi species, 15.2 percent by Salmonella Typhimurium species, 12.1% by Salmonella Typhi species, and 12.1% by Salmonella Arizona species. Most of the isolates demonstrated resistance to 1st-2nd generation cephalospori. A few Salmonella Enterica strains were also susceptible to the primary antimicrobial drugs salmonellosis, such as, chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole. Additionally, the results showed the emergence of two Salmonella Enterica strains that were sensitive to 3rd generation cephalosporins. In Salmonella Enterica strains, the existence of carb-like, dihydrofolate reductase1 (dfrA1), florfenicol resistance genes (floR), and Tetracycline resistance protein A (tetA) genes, respectively, was accompanied with acclimation to different antibacterial drugs (chloramphenicol, tetracycline, B-lactam drugs and trimethoprim-sulfamethoxazole). 

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Published

05-01-2023

How to Cite

Gohar, A., Alam, M. A., Rehman, E., Rehman, H. U., & Aziz , S. (2023). Prevalence, serotypes, and third generation antibiotic-resistant patterns of Salmonella enteric serotype Typhi, in Peshawar. International Journal of Health Sciences, 6(S7), 6757–6766. Retrieved from https://sciencescholar.us/journal/index.php/ijhs/article/view/13826

Issue

Vol. 6 No. S7 (2022)

Section

Peer Review Articles
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