Frequency of Diabetic and Non-diabetic patients having fetal anomalies at 3rd trimester using ultrasound
Keywords:
Pre-gestational, gestational diabetes, OligohydramniosAbstract
Background: Pre-gestational or gestational diabetes in pregnancy is now more common among pregnant mothers as a result of the obesity pandemic. Objective: To determine frequency of diabetic and non-diabetic patients having fetal anomalies at 3rd trimester using ultrasound. Methodology: Descriptive study was conducted at radiology department Chughtai Lab, Lahore. About 250 Diabetic and Non-Diabetic pregnant women of all age were included in this study. Consecutive sampling technique was used Data was analyzed by SSPS version 24.0. All quantitative variables were reported in mean ± S.D were presented in frequency and percentage and bar charts were presented. Results: The mean age of 250 participants was 28±5.1 with minimum age of 15 years and maximum age of 45 years. Out of 250 participants, 210(84%) had no Gestational Diabetes Mellitus and 40(16%) had Gestational Diabetes Mellitus. Out of 250 patients, 204(81.6%) had adequate Amniotic Fluid Index value, 27(10.8%) had Oligohydramnios and 19(7.6%) had Polyhydramnios. In our study 16(6.4%) diabetic patients and 26(10.4%) non-diabetic patients have anomalies. Conclusion: The study concluded that frequency of anomalies doesn’t depend on patients being diabetic or non-diabetic. As in our study diabetic patients are lesser anomalies than the non-diabetic patients.
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Asmat, U, Abad, K. and Ismail, K. Diabetes mellitus and oxidative stress—a concise review. Saudi Pharmaceutical Journal. 2016.1;24(5):547-53.
Chih-Ping Chen, Congenital Malformations Associated with Maternal Diabetes, Taiwanese Journal of Obstetrics and Gynecology, Volume 44, Issue 1, 2005, Pages 1-7, ISSN 1028-4559.
Cho N, Shaw J, Karuranga S, Huang Y, da Rocha Fernandes J, Ohlrogge A, et al.. IDF Diabetes Atlas: global estimates of diabetes prevalence for 2017 and projections for (2045). Diabetes Res Clin Pract. (2018) 138:271–81. 10.1016/j.diabres.2018.02.023
Reece EA, Homko CJ, Wu YK, Wiznitzer A. The role of free radicals and membrane lipids in diabetes-induced congenital malformations. J Soc Gynecol Investig 1998;5:178-87
Ural, S.H. and Nagey, D.A. Diabetes Mellitus and Pregnancy. Topics in Obstetrics & Gynecology.2008;18(1):1- 4.
Evers, I.M., de Valk, H.W. and Visser, G.H. Risk of complications of pregnancy in women with type 1 diabetes: nationwide prospective study in the Netherlands. Bmj. 2004. 328(7445):915.
Designua k. Types 1 diabetes mellitus vector image on VectorStock [Internet]. VectorStock. 2020 [cited 2022Dec31]. Available from: https://www.vectorstock.com/royalty-free-vector/types-1-diabetes-mellitus-vector-31601876.
Lakshmi PV, Jain S, Prinja S. Diagnostic accuracy of tests for type 2 diabetes and Prediabetes: A systematic review and meta-analysis. PLOS ONE. 2020;15(11).
Martin JA, Hamilton BE. Births: Final data for 2018. National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. U.S. National Library of Medicine; 2019 nov;68(13);1-47.
Katz J, Kozuki N, Adair L. National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010. The Lancet Global Health. 2013;1(1).
Leese GP, Mires GJ, Murphy DJ. Poor glycated haemoglobin control and adverse pregnancy outcomes in type 1 and type 2 diabetes mellitus: Systematic review of observational studies. BMC Pregnancy and Childbirth. 2006;6(1):1–13.
Hogston P, Rowe DJ, Dennis KJ. Reference values for 75 g oral glucose tolerance test in pregnancy. BMJ. 1988;296(6623):676–8.
Ornoy A, Becker M, Weinstein-Fudim L, Ergaz Z. Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review. Int J Mol Sci. 2021 Mar 15;22(6):2965.
Donovan LE, Ryan EA. Association between maternal diabetes, being large for gestational age and breast-feeding on being overweight or obese in childhood. Diabetologia. 2018;62(2):249–58.
Rouse DJ, Owen J. Prophylactic cesarean delivery for fetal macrosomia diagnosed by means of ultrasonography—a Faustian bargain? American Journal of Obstetrics and Gynecology. 1999;181(2):332–8.
Ott W, Doyle S, Flamm S. Accurate ultrasonic estimation of fetal weight. American Journal of Perinatology. 1985;2(03):178–82.
Bhutta R. Diabetes mellitus, gestational diabetes mellitus and work up [Internet]. Labpedia.net. 2022 [cited 2022Sep31]. Available from: https://labpedia.net/gestational-diabetes-mellitus-oral-gtt/
Li L-J, Ikram MK, Gluckman P, Kwek K, Saw S-M. Blood pressure and retinal microvascular characteristics during pregnancy. Hypertension. 2012;60(1):223–30.
Nizard J, Ville Y. The fetus of a diabetic mother: Sonographic evaluation. Seminars in Fetal and Neonatal Medicine. 2009;14(2):101–5.
Little R. Diabetes tests & diagnosis [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. U.S. Department of Health and Human Services; [cited 2022Dec31]. Available from: https://www.niddk.nih.gov/health-information/diabetes/overview/tests-diagnosis
Euclid A. Amniocentesis: Purpose, procedure, risks, Recovery & Results [Internet]. Cleveland Clinic. 2022 [cited 2022Sep31]. Available from: https://my.clevelandclinic.org/health/treatments/4206-genetic-amniocentesis.
Gabbay-Benziv R. Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis. World Journal of Diabetes. 2015;6(3):481–9.
Deng F, Radswiki T. Diabetic embryopathy. Radiopaediaorg. 2011;:30–8.
Abourawi FI. Diabetes mellitus and pregnancy [Internet]. The Libyan journal of medicine. U.S. National Library of Medicine; 2006 [cited 2022Oct18]. Available from: https://pubmed.ncbi.nlm.nih.gov/21526019/
Kallem VR, Pandita A, Pillai A. Infant of diabetic mother: What one needs to know? The Journal of Maternal-Fetal & Neonatal Medicine. 2018;33(3):482–92.
Kereliuk SM, Dolinsky VW. Recent experimental studies of maternal obesity, diabetes during pregnancy and the developmental origins of cardiovascular disease. International Journal of Molecular Sciences. 2022;23(8):4467–74.
Syngelaki A, Zidere V, Nicolaides KH. Diagnosis of fetal non‐chromosomal abnormalities on routine ultrasound examination at 11–13 weeks' gestation. Ultrasound in Obstetrics & Gynecology. 2019;54(4):468–76.
Moore GS, Post AL, West NA, Hart JE. Fetal weight estimation in diabetic pregnancies using the gestation-adjusted projection method. Journal of Ultrasound in Medicine. 2015;34(6):971–5.
Riskin S, Auslander R. Quality of medical care in diabetic women undergoing fertility treatment. Diabetes Care. 2011;34(10):2164–9.
Hina GE, Gillani SA, Fatima M, Khalid Q. Sonographic evaluation of fetal complications in gestational diabetes during 3rd trimester of pregnancy. Pakistan BioMedical Journal. 2022;:262–6.
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