Incidence of multidrug resistance and extended spectrum beta-lactamase expression in community-acquired urinary tract infection among different age groups of patients
Keywords:
urinary tract infections, E. coli, multi-drug resistance, extended spectrum beta-lactamaseAbstract
Background and Aim: Escherichia coli was the most prevalent cause for urinary tract infections (UTIs). These bacteria also generate extended spectrum b-lactamases (ESBL), which inactivate penicillins and cephalosporins. The purpose of the current study is to determine the incidence of multidrug resistance and extended beta-lactamase expression in community-acquired urinary tract infection (UTIs) among patients of different age groups. Patients and Methods: This prospective cross-sectional study was conducted on 186 uropathogens investigated in the diagnostic center of Tertiary Care Hospital Peshawar from January 2022 to December 2022. Patients of either gender or any age with suspected UTIs associated with K. pneumoniae and E. coli were derived from urine specimen were enrolled. Identification and analysis of antimicrobial susceptibility was done using Disc diffusion method and Double Disc synergy test. SPSS version 27 was used for data analysis. Results: Of the total 186 Gram-negative uropathogens, there were 57 (30.6%) male and 129 (59.4%) female. The incidence of E. coli and K. pneumoniae was 138 (74.2%) and 48 (25.8%) respectively. The prevalence of uropathogens identified was in 71% females and 29% males.
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