The relationship between HPV positivity and abnormal cervical cytology changes with age in perimenopausal women
Keywords:
HPV, abnormal cervical cytology, menopause, perimenopausal women, menopause transition, human papilloma virusAbstract
Background: In this research, premenopausal women with HR-HPV infections and atypical cervical smears were compared by age. Materials and method: 200 regularly screened women between the ages of 36 and 60 had a cervical smear and HPV detection. Demographic, behavioral, and medical data were gathered by telephone surveys. Descriptive analysis was used to look at the connection between HR-HPV infections and cervical aberrations by age. Results: Age significantly decreased the number of cases of cervical abnormalities, HR-HPV, and human papillomavirus, as well as the correlation among these disorders. In younger females with abnormalities, HR-HPV detection was 60%; however, it steadily decreased to 30% in "50-54-year-old" women, without abnormalities found in 55-60 years old females. Different relationships between HR-HPV infection and anomalies remained found in females over 45, a pattern not observed in females who were young by age. Conclusion: Age had no effect on several kinds of low-grade and severe anomalies, but we saw a decline in the agreement among cytological results and HR-HPV tests.
Downloads
References
Aker SŞ, Ağar E, Tinelli A, Hatirnaz S, Ortaç F. The Impact of HPV Diagnosis and Abnormal Cervical Cytology Results on Sexual Dysfunction and Anxiety. International journal of environmental research and public health. 2023;20(4):3630.
Al Niyazee AAQ, Abedalrahman SK, Abdulrahman ZN, Zadawy IA. Prevalence of human papilloma virus positivity and cervical cytology. Is there a new HPV gene? Middle East Journal of Family Medicine. 2019;7(10):10.
Alay I, Kaya C, Karaca I, Yildiz S, Baghaki S, Cengiz H, et al. The effect of being diagnosed with human papillomavirus infection on women's sexual lives. Journal of Medical Virology. 2020;92(8):1290-7.
Aydogan Kirmizi D, Baser E, Demir Caltekin M, Onat T, Sahin S, Yalvac ES. Concordance of HPV, conventional smear, colposcopy, and conization results in cervical dysplasia. Diagnostic Cytopathology. 2021;49(1):132-9.
Chang C-L, Ho S-C, Su Y-F, Juan Y-C, Huang C-Y, Chao A-S, et al. DNA methylation marker for the triage of hrHPV positive women in cervical cancer screening: Real-world evidence in Taiwan. Gynecologic Oncology. 2021;161(2):429-35.
Choi MS, Lee YJ, Lee EH, Ji YI, Park MJ. Factors Associated with Cyto-Histological Misinterpretation of Cervical Smear according to Menopausal Status. Journal of Menopausal Medicine. 2022;28(2):78-84.
Donkoh ET, Asmah RH, Agyemang-Yeboah F, Dabo EO, Wiredu EK. Prevalence and distribution of vaccine-preventable genital human Papillomavirus (Hpv) genotypes in ghanaian women presenting for screening. Cancer Control. 2022;29:10732748221094721.
Elasy AN, Aziza A-K, Hamed BM. The relation between human papilloma virus serotype infection and colposcopic, cytological and histopathological abnormalities among the Egyptian women: retrospective study Short title: Colposcopy, cytology, and histopathology of Egyptian women with HPV.
Kaiser LA, Kupec T, Najjari L, Stickeler E, Wittenborn J. Predictors of CIN2+ in Patients with PAP III-P (ASC-H): A Cross-Sectional Study. Diagnostics. 2023;13(6):1066.
Koc S, Yuksel D, Kayikcioglu F. Colposcopic histopathology results of patients over 50: Is HPV genotyping useful? Current Problems in Cancer. 2022;46(1):100764.
Landy R, Hollingworth T, Waller J, Marlow LA, Rigney J, Round T, et al. Non-speculum clinician-taken samples for human papillomavirus testing: a cross-sectional study in older women. British Journal of General Practice. 2022;72(721):e538-e45.
Li Y, Luo H, Zhang X, Chang J, Zhao Y, Li J, et al. Development and validation of a clinical prediction model for endocervical curettage decision-making in cervical lesions. BMC cancer. 2021;21:1-11.
Liu Q, Zhang T, Chen L, Zhou X, Zhang X, Zheng W, et al. Correlation of immediate prevalence of cervical precancers and cancers with HPV genotype and age in women with ASC-US/hrHPV+: a retrospective analysis of 2292 cases. Journal of Clinical Pathology. 2023.
Long T, Zhang C, He G, Hu Y, Lin Z, Long L. Bacterial vaginosis decreases the risk of cervical cytological abnormalities. Cancer Prevention Research. 2023;16(2):109-17.
Salibay C, Chen Z, Ma B, Pan H, Hijazi M, Elatre W, et al. High-risk HPV testing improves accuracy in detection of CIN2+ lesions in ASC-H postmenopausal women? An academic hospital experiences. Journal of the American Society of Cytopathology. 2023;12(1):58-65.
Shashidhar SC, Sonkusare S, Ramesh PS, Shetty AK, Shetty V, Devegowda D. Prevalence of high-risk human papillomavirus in women with normal and abnormal pap smear: a cross sectional study from a tertiary hospital in South India. Indian Journal of Gynecologic Oncology. 2021;19:1-8.
Sugisawa A, Toyoda Z, Tanabe Y, Uehara K, Oshiro A, Yamazato R, et al. Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis. Menopause.10.1097.
Williams MP, Kukkar V, Stemmer MN, Khurana KK. Cytomorphologic findings of cervical Pap smears from female‐to‐male transgender patients on testosterone therapy. Cancer Cytopathology. 2020;128(7):491-8.
YALCINKAYA C. Prevalence of cervical high-risk human papillomavirus and cytological abnormalities in elderly Turkish women. Marmara Medical Journal. 2022;35(3):288-92.
Yu H, Ma L, Bian M, Li Q, Liang H. Association of abnormal vaginal microflora and HPV infection in cervical precancerous lesions: a retrospective study. The Journal of Infection in Developing Countries. 2022;16(06):1089-95.
ZERGEROĞLU S, Özkan ZS, AYDIN AH. Are the correlation results of HPV positive cases with cervical smear always consistent? Journal of Medicine and Palliative Care. 2023;4(2):158-62.
Published
How to Cite
Issue
Section
Copyright (c) 2023 International journal of health sciences
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.