Restless leg syndrome in patients on hemodialysis

https://doi.org/10.53730/ijhs.v7nS1.14286

Authors

  • Mazharulhaq Mazharulhaq Assistant Professor Nephrology, Institute of Kidney Diseases, Hayatabad Peshawar
  • Zahid Ahmad Assistant Consultant Nephrology, Quaid e Azam International Hospital, Islamabad
  • Ayesha Arshad Consultant Nephrology, PAF Hospital, Islamabad
  • Kulsoom Ilyas Nephrologist / Medical Specialist, Doctors Plus Pharmacy and Diagnostics, Sector A, Bahria Enclave Islamabad
  • Behzad Kaleem Baloch Assistant Prof Nephrology, Mufti Mehmood Teaching Hospital, Dera Ismail Khan

Keywords:

Hemodialysis, Restless leg syndrome, RLS severity

Abstract

Background and Aim: Restless legs syndrome (RLS) is a prevalent neurological disease that is frequently misdiagnosed due to comparable signs and symptoms to other disorders such as diabetes, migraine, and cardiovascular disease. RLS may deteriorate with age, and it is more frequent in women than in males. The incidence of RLS varies from 6.6% to 80% in the general population. The present study aimed to assess the RLS in patients on hemodialysis. Patients and Methods: A questionnaire based study was conducted on 116 consecutive hemodialysis patients in the Department of Neurology and Nephrology of Institute of Kidney Diseases Hayatabad, Peshawar and PAF Hospital, Islamabad for the Duration from June 2022 to December 2022. Patients’ history included a history of drug, predialysis duration, and hemodialysis duration. Data was obtained using a standardized questionnaire that includes demographic variables such as personal history, family history, disease history, and smoking history. 

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References

Capelli I, Pizza F, Ruggeri M, Gasperoni L, Carretta E, Donati G, Cianciolo G, Plazzi G, La Manna G. Time evolution of restless legs syndrome in haemodialysis patients. Clinical Kidney Journal. 2021 Jan;14(1):341-7.

Yang B, Yin H, Wang J, Gan J, Li J, Han R, Pei M, Song L, Yang H. A metabolic biomarker panel of restless legs syndrome in peritoneal dialysis patients. Metabolomics. 2022 Oct 18;18(11):79.

Matar SG, El-Nahas ZS, Aladwan H, Hasanin M, Elsayed SM, Nourelden AZ, Benmelouka AY, Ragab KM. Restless Leg Syndrome in Hemodialysis Patients: A Narrative Review. The Neurologist. 2022 Jul 1;27(4):194-202.

Akın S, Bölük C, Börü ÜT, Taşdemir M, Gezer T, Şahbaz FG, et al. (2019). Restless legs syndrome in type 2 diabetes mellitus. Prim Care Diabetes. 13(1):87-91.

Alangari MI, Aldubayan AK, Alsharidah AM, Saber Y, Olaish AH, Taki A, et al. (2016). The Prevalence And Severity Of Restless Legs Syndrome Among Pregnant Women In Saudi Arabia. B65 Things that go bump in the night: sleep case studies and non-osa sleep: Am J Respir Crit Care Med American Thoracic Society; p.A4225-A.

Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. (2014). Restless legs syndrome/Willis–Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med. 15(8):860-73.

Van Oosterhout W, Van Someren E, Louter M, Schoonman G, Lammers G, Rijsman R, et al. (2016). Restless legs syndrome in migraine patients: prevalence and severity. Eur J Neurol. 23(6):1110-6.

Wali SO, Abaalkhail B (2015). Prevalence of restless legs syndrome and associated risk factors among middle-aged Saudi population.Ann Thorac Med. 10(3):193.

Batool-Anwar S, Li Y, De Vito K, Malhotra A, Winkelman J, Gao X (2016). Lifestyle factors and risk of restless legs syndrome: prospective cohort study. J CLIN SLEEP MED. 12(02):187-94.

Lamberti N, López-Soto PJ, Rodríguez-Borrego MA, Straudi S, Basaglia N, Zamboni P, et al. (2019). Restless Leg Syndrome in Peripheral Artery Disease: Prevalence among Patients with Claudication and Benefits from Low-Intensity Exercise. J.Clin Med. 8(9):1403.

Leschziner GD (2018). Restless legs syndrome. Sleep Disorders in Psychiatric Patients: Springer; p. 175-88.

Mahmood K, Farhan R, Surani A, Surani AA, Surani S (2015). Restless legs syndrome among Pakistani population: a crosssectional study. Int sch Res notices. 2015.

Mahmood K, Farhan R, Surani A, Surani AA, Surani S (2015). Restless legs syndrome among Pakistani population: a crosssectional study. Int Sch Res Notics. 2015.

Santos RSS, Coelho FMS, da Silva BC, Graciolli FG, Dominguez WV, de Menezes Montenegro FL, et al. (2016). Parathyroidectomy improves restless leg syndrome in patients on hemodialysis. PLoS One. 11(5).

Shi Y, Yu H, Ding D, Yu P, Wu D, Hong Z (2015). Prevalence and risk factors of restless legs syndrome among Chinese adults in a rural community of Shanghai in China. PLoS One. 10(3).

Molnar MZ, Lu JL, Kalantar-Zadeh K, Kovesdy CP. Association of incident restless legs syndrome with outcomes in a large cohort of US veterans. J Sleep Res. 2016;25(1):47–56. doi:10.1111/jsr.2016.25.issue-1.

DeFerio JJ, Govindarajulu U, Brar A, Cukor D, Lee KG, Salifu MO. Association of restless legs syndrome and mortality in end-stage renal disease: an analysis of the United States Renal Data System (USRDS). BMC Nephrol. 2017;18(1):258. doi:10.1186/s12882-017-0660-0.

Urabe S, Hosono T, Hyodo T, et al. Restless legs syndrome effectively treated with constant-pressure predilution online hemodiafiltration. J Artif Organs. 2019;22(3):253–255. doi:10.1007/s10047-019-01100-y.

Ahmed, S. M., Luo, L., Namani, A., Wang, X. J., & Tang, X. (2017). Nrf2 signaling pathway: Pivotal roles in inflammation. Biochimica et biophysica acta: Molecular Basis of Disease, 1863(2), 585–597. https://doi.org/10.1016/j.bbadis.2016.11.005.

Bellei, E., Monari, E., Ozben, S., Koseoglu Bitnel, M., Topaloglu Tuac, S., Tomasi, A., & Bergamini, S. (2018). Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis. Brain and Behavior, 8(10), e01062. https://doi.org/10.1002/brb3.1062

Rizek, P., & Kumar, N. (2017). Restless legs syndrome. CMAJ: Canadian Medical Association Journal = journal de l’Association medicale canadienne, 189(6), E245. https://doi.org/10.1503/cmaj.160527.

Brzuszek A, Hazara AM, Bhandari S. The prevalence and potential aetiological factors associated with restless legs syndrome in patients with chronic kidney disease: a cross-sectional study. International Urology and Nephrology. 2022 Oct;54(10):2599-607.

de Menezes, A. F., Motta, D., de Carvalho, F. O., Santana-Santos, E., de Andrade Júnior, M. P., Figueirôa, M. F., Farias, M., & Bastos, K. A. (2018). Restless legs syndrome in dialysis patients: Does the dialysis modality influence its occurrence and severity? International Journal of Nephrology, 2018, 1414568. https://doi.org/10.1155/2018/1414568.

Li, P. K., Chow, K. M., Van de Luijtgaarden, M. W., Johnson, D. W., Jager, K. J., Mehrotra, R., Naicker, S., Pecoits-Filho, R., Yu, X. Q., & Lameire, N. (2017). Changes in the worldwide epidemiology of peritoneal dialysis. Nature Reviews. Nephrology, 13(2), 90–103. https://doi.org/10.1038/nrneph.2016.181.

Lee, T. H., Yen, T. T., Chiu, N. Y., Chang, C. C., Hsu, W. Y., Chang, Y. J., & Chang, T. G. (2019). Depression is differently associated with sleep measurement in obstructive sleep apnea, restless leg syndrome and periodic limb movement disorder. Psychiatry Research, 273, 37–41. https://doi.org/10.1016/j.psychres.2018.12.166.

Mondello, S., Kobeissy, F. H., Mechref, Y., Zhao, J., El Hayek, S., Zibara, K., Moresco, M., Plazzi, G., Cosentino, F., & Ferri, R. (2021). Searching for novel candidate biomarkers of RLS in blood by proteomic analysis. Nature and Science of Sleep, 13, 873–883. https://doi.org/10.2147/NSS.S311801.

Published

23-05-2023

How to Cite

Mazharulhaq, M., Ahmad, Z., Arshad, A., Ilyas, K., & Baloch, B. K. (2023). Restless leg syndrome in patients on hemodialysis. International Journal of Health Sciences, 7(S1), 853–859. https://doi.org/10.53730/ijhs.v7nS1.14286

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Peer Review Articles

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