Effect of PRF on extraction socket healing

Kashif Adnan; Umair Farrukh; Huma Sarwar; Joham Gul; Satinder Pal Singh; Shah Salman Khan; Meshal Muhammad Naeem

doi:10.53730/ijhs.v7nS1.14302

Authors

Kashif Adnan BDS, MFDS RCPS (Glasgow), FICD Demonstrator / Registrar De’Montmorency College of dentistry, Lahore
Umair Farrukh Vice Principal, Associate Professor & Head of Department of Community Dentistry, Watim Dental College, Rawalpindi
Huma Sarwar Senior Registrar Department of Operative Dentistry Dr Ishrat ul ebad Khan Institute of Oral Health Sciences Dow University of Health Sciences
Joham Gul Lecturer Department of Oral Medicine Hamdard University Dental College, Karachi
Satinder Pal Singh BDS (TMDC-RC, INDIA) │Masters in Global Health Administration (Fairleigh Dickinson University, Vancouver, CANADA) │General Dentist (Trusmiles Dental Clinic, Punjab, India)
Shah Salman Khan Assistant Professor Department of Oral Biology Watim Dental COllege Rawalpindi
Meshal Muhammad Naeem Lecturer Department of Periodontology. Dr Ishrat ul ebad Khan Institute of Oral Health Sciences Dow University of Health Sciences

Keywords:

PRF, extraction, socket healing

Abstract

Extraction socket healing is a critical process in dental care that determines the success of subsequent dental treatments, such as implant placement. Platelet-rich fibrin (PRF) has emerged as a promising biomaterial for enhancing wound healing in various medical and dental applications. This abstract aims to provide a comprehensive overview of the effect of PRF on extraction socket healing, with a particular focus on the sample size of studies conducted in this area. PRF is an autologous blood-derived product rich in growth factors, cytokines, and platelets, which play key roles in tissue repair and regeneration. When applied to extraction sockets, PRF promotes accelerated wound healing by stimulating angiogenesis, enhancing cell proliferation, and modulating the inflammatory response. These biological effects contribute to improved soft tissue healing and osseous regeneration. A thorough review of the literature reveals that several studies have investigated the effect of PRF on extraction socket healing, with varying sample sizes. Sample sizes ranged from small-scale studies with fewer than 20 participants to larger-scale investigations involving over 100 subjects. The inclusion of sufficient sample size is crucial for obtaining statistically significant results and ensuring the generalizability of findings.

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