Clinicopathological features and surgical treatment of thyroid papillary carcinoma in Hashimoto thyroiditis
Keywords:
thyroid papillary carcinoma, clinicopathological features, Hashimoto thyroiditisAbstract
Background and Aim: Papillary thyroid carcinoma (PTC) is the most prevalent types of thyroid cancer. The present study aimed to investigate the clinicopathological features and surgical treatment of thyroid papillary carcinoma in Hashimoto thyroiditis. Patients and Methods: A cross-sectional study was carried out on 486 papillary thyroid carcinoma patients in the surgical department of Mardan Medical Complex, Mardan Pakistan from March 2020 to March 2023. All the patients were categorized into two groups: Group-I (papillary thyroid carcinoma with Hashimoto thyroiditis) and Group-II (papillary thyroid carcinoma without Hashimoto thyroiditis). Serum thyroid-stimulating hormone (TSH), age, central compartment lymph node metastasis (CLNM), gender, nodular size, and invasive status were different clinicopathological factors recorded. SPSS version 27 was used for data analysis. Results: The overall mean age was 42.84±10.8 years. Out of 486 patients, Group-I had 76 (15.6%) patients whereas Group-II had 410 (84.4%) patients. There were 52 (10.7%) male and 434 (89.3%) females. The incidence of final diagnosis of benign thyroid nodule and PTC was 53.9% (n=262) and 46.1% (n=224) respectively. The prevalence of PT in Group-I was significantly higher 56.8% 57.9% (n=44) than in Group-II 43.4% (n=178).
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El-Shareif HJ. Clinicopathological features of differentiated thyroid carcinoma referred to radioiodine therapy at Tripoli Medical Center. Thyroid Res Pract 2018;15:3-9.
Al‑Qahtani KH, Tunio MA, Asiri MA, Bayoumi Y, Balbaid A, Aljohani NJ, et al. Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years. Clin Interv Aging 2016;11:1169‑74.
Zhang Y, Lu KN, Ding JW, Peng Y, Pan G, Teng LS, Luo DC. Identification of Long Noncoding RNAs Associated with the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated with Hashimoto’s Thyroiditis. Frontiers in Oncology. 2022 Mar 11;12:791.
Halada S, Baran JA, Bauer AJ, Ricarte-Filho JC, Isaza A, Patel T, Franco AT, Mostoufi-Moab S, Adzick NS, Kazahaya K, Bhatti TR. Clinicopathologic Characteristics of Pediatric Follicular Variant of Papillary Thyroid Carcinoma Subtypes: A Retrospective Cohort Study. Thyroid. 2022 Nov 1;32(11):1353-61.
Miller KD, Ortiz AP, Pinheiro PS, Bandi P, Minihan A, Fuchs HE, et al. Cancer Statistics for the US Hispanic/Latino Population, 2021. CA Cancer J Clin (2021) 1(6):466–87. doi: 10.3322/caac.21695
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin (2021) 71(3):209–49. doi: 10.3322/caac.21660
Ralli M, Angeletti D, Fiore M, D'Aguanno V, Lambiase A, Artico M, et al. Hashimoto's Thyroiditis: An Update on Pathogenic Mechanisms, Diagnostic Protocols, Therapeutic Strategies, and Potential Malignant Transformation. Autoimmun Rev (2020) 19(10):102649. doi: 10.1016/j.autrev.2020.102649
Davies L, Welch HG. Increasing Incidence of Thyroid Cancer in the United States, 1973-2002. Jama (2006) 295(18):2164–7. doi: 10.1001/jama.295.18.2164
Li Y, Teng D, Ba J, Chen B, Du J, He L, et al. Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders: Epidemiological Evidence From 31 Provinces of Mainland China. Thyroid (2020) 30(4):568–79. doi: 10.1089/thy.2019.0067
Boi F, Pani F, Calo PG, Lai ML, Mariotti S. High Prevalence of Papillary Thyroid Carcinoma in Nodular Hashimoto's Thyroiditis at the First Diagnosis and During the Follow-Up. J Endocrinol Invest (2018) 41(4):395– 402. doi: 10.1007/s40618-017-0757-0
Liu Y, Lv H, Zhang S, Shi B, Sun Y. The Impact of Coexistent Hashimoto's Thyroiditis on Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma. Front Endocrinol (Lausanne) (2021) 16:772071. doi: 10.3389/fendo.2021.772071
Lau J, Lee J, Mahipal M, Yang SP, Tan WB, Yuan NK, et al. Hashimoto's Thyroiditis on Outcomes in Papillary Thyroid Cancer Revisited: Experience From South East Asia. Ann R Coll Surg Engl (2022) 4. doi: 10.1308/ rcsann.2021.0224
Xu S, Huang H, Qian J, Liu Y, Huang Y, Wang X, et al. Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes. JAMA Netw Open (2021) 4(7):e2118526. doi: 10.1001/jamanetworkopen.2021.18526
Dong X, Jin C, Chen D, Chen Y, Ye ZQ, Zhang X, et al. Genomic InstabilityRelated LncRNA Signature Predicts the Prognosis and Highlights LINC01614 Is a Tumor Microenvironment-Related Oncogenic lncRNA of Papillary Thyroid Carcinoma. Front Oncol (2021) 16:737867. doi: 10.3389/fonc.2021.737867
Jiang B, Chen Y, Xia F, Li X. PTCSC3-Mediated Glycolysis Suppresses Thyroid Cancer Progression via Interfering With PGK1 Degradation. J Cell Mol Med (2021) 25(17):8454–63. doi: 10.1111/jcmm.16806
Mei D, Song H, Wang K, Lou Y, Sun W, Liu Z, et al. Up-Regulation of SUMO1 Pseudogene 3 (SUMO1P3) in Gastric Cancer and Its Clinical Association. Med Oncol (2013) 30(4):709. doi: 10.1007/s12032-013-0709-2
Wang H, Wu J, Zhang X, Ding L, Zeng Q. Microarray Analysis of the Expression Profile of lncRNAs Reveals the Key Role of lncRNA BC088327 as an Agonist to Heregulin−1b−Induced Cell Proliferation in Peripheral Nerve Injury. Int J Mol Med (2018) 41(6):3477–84. doi: 10.3892/ijmm.2018.3571
Sakiz D, Sencar ME, Calapkulu M, Ozturk Unsal I, Aktas L, Ucan B, et al. The Effects of Chronic Lymphocytic Thyroiditis on Clinicopathologic Factors in Papillary Thyroid Cancer. Endocr Pract (2021) 27(12):1199–204. doi: 10.1016/ j.eprac.2021.07.011
Zeng R, Zhao M, Niu H, Yang KX, Shou T, Zhang GQ, et al. Relationship Between Hashimoto's Thyroiditis and Papillary Thyroid Carcinoma in Children and Adolescents. Eur Rev Med Pharmacol Sci (2018) 22(22):7778– 87. doi: 10.26355/eurrev_201811_16401
Graceffa G, Patrone R, Vieni S, Campanella S, Calamia S, Laise I, et al. Association Between Hashimoto's Thyroiditis and Papillary Thyroid Carcinoma: A Retrospective Analysis of 305 Patients. BMC Endocr Disord (2019) 19(Suppl 1):26. doi: 10.1186/s12902-019-0351-x
Molnár C, Molnár S, Bedekovics J, Mokánszki A, Győry F, Nagy E, et al. Thyroid Carcinoma Coexisting With Hashimoto's Thyreoiditis: Clinicopathological and Molecular Characteristics Clue Up Pathogenesis. Pathol Oncol Res (2019) 25(3):1191–7. doi: 10.1007/s12253-019-00580-w
Kim WW, Ha TK, Bae SK. Clinical Implications of the BRAF Mutation in Papillary Thyroid Carcinoma and Chronic Lymphocytic Thyroiditis. J Otolaryngol Head Neck Surg (2018) 47(1):4. doi: 10.1186/s40463-017-0247-6
Lee I, Kim HK, Soh EY, Lee J. The Association Between Chronic Lymphocytic Thyroiditis and the Progress of Papillary Thyroid Cancer. World J Surg (2020) 44(5):1506–13. doi: 10.1007/s00268-019-05337-9
Pilli T, Toti P, Occhini R, Castagna MG, Cantara S, Caselli M, et al. Chronic Lymphocytic Thyroiditis (CLT) Has a Positive Prognostic Value in Papillary Thyroid Cancer (PTC) Patients: The Potential Key Role of Foxp3+ T Lymphocytes. J Endocrinol Invest (2018) 41(6):703–9. doi: 10.1007/s40618-017-0794-8
Pan J, Ye F, Yu C, Zhu Q, Li J, Zhang Y, et al. Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution. Front Cell Dev Biol (2021) 5:758339. doi: 10.3389/ fcell.2021.758339
Wang X, Zhang Y, Zheng J, Yao C, Lu X. LncRNA UCA1 Attenuated the Killing Effect of Cytotoxic CD8 + T Cells on Anaplastic Thyroid Carcinoma via miR-148a/PD-L1 Pathway. Cancer Immunol Immunother (2021) 70 (8):2235–45. doi: 10.1007/s00262-020-02753-y.
Zhao J, Li Z, Chen Y, Zhang S, Guo L, Gao B, et al. MicroRNA−766 Inhibits Papillary Thyroid Cancer Progression by Directly Targeting Insulin Receptor Substrate 2 and Regulating the PI3K/Akt Pathway. Int J Oncol (2019) 54 (1):315–25. doi: 10.3892/ijo.2018.4615
Lin RX, Yang SL, Jia Y, Wu JC, Xu Z, Zhang H. Epigenetic Regulation of Papillary Thyroid Carcinoma by Long Non-Coding RNAs. Semin Cancer Biol (2021) 27:S1044-579X(21)00077-8. doi: 10.1016/j.semcancer.2021.03.027
Benvenga S, Trimarchi F. Changed presentation of Hashimoto’s thyroiditis in North-Eastern Sicily and Calabria (Southern Italy) based on a 31-year experience. Thyroid. 2008;18(4):429-441. doi:10.1089/thy.2007.0234
Lee JH, Kim Y, Choi JW, Kim YS. The association between papillary thyroid carcinoma and histologically proven Hashimoto’s thyroiditis: a meta-analysis. Eur J Endocrinol. 2013;168(3):343-349. doi:10.1530/EJE-12-0903
Caturegli P, De Remigis A, Chuang K, Dembele M, Iwama A, Iwama S. Hashimoto’s thyroiditis: celebrating the centennial through the lens of the Johns Hopkins hospital surgical pathology records. Thyroid. 2013;23(2): 142-150. doi:10.1089/thy.2012.0554
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