Acute renal failure as a manifestation of multiple myeloma frequency and clinical implications
Keywords:
renal failure, multiple myeloma, mortality, risk factors, recoveryAbstract
Objective: Aim was to determine the association and clinical implications of renal failure among patients of multiple myeloma. Study Design: Prospective/observational study. Place and Duration: Diagnostic and research Laboratory Liaquat university of Medical and health sciences jamshoro Hyderabad. June 2021 to may 2022. Methods: Total 192 patients of multiple myeloma were presented in this study. Patients were enrolled after obtaining written consent detailing age, sex, and the presence or absence of any and all comorbidities. A serum creatinine level of 177 mol/L or above (>2 mg/dL) was considered indicative of renal failure. All the patients received chemotherapy for recovery. Response rate to chemo and survival among all patients were determined. SPSS 23.0 was used to analyze all data. Results: There were 106 (55.2%) males and 86 (44.8%) cases were females. Patients mean age was 51.6 ±13.46 years. Chronic renal disease, diabetes, hypercalcemia, dehydration, and the use of nephrotoxic medicines were all risk factors. We found renal failure in 43 (22.4%) cases. Patients without renal failure had higher response rate 90 (60.4%) to chemotherapy as compared to patients of renal failure 16 (37.2%). 13 (30.2%) cases were recovered from renal failure and mean time of survival was 3.3±3.18 years.
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