Pattern of anemia and associated parameters in HIV positive patients taking highly active retroviral therapy (HAART)

https://doi.org/10.53730/ijhs.v7nS1.14408

Authors

  • Durga Devi M.phil Haematology, Lecturer, pathology Department, Bilawal medical college for boys, Liaquat university of Medical and health sciences Jamshoro hyderabad
  • Muhammad Rahil Khan FCPS histopathologist, Assistant professor, Pathology Department, Liaquat university of Medical and health sciences jamshoro Hyderabad
  • Abdullah Khan Demonstrator, Biochemistry Department Jhalawan medical college Khuzdar Balochistan
  • Suresh Kumar Assistant Professor, Pathology Department, Jinnah Sindh Medical University Karachi
  • Muhammad Anique Senior Lecturer, Medical Education, Department, Bhitai Dental and Medical College Mirpurkhas
  • Sidrah Lecturer, Pathology department, Bilawal Medical College for boys, LUMHS Jamshoro Hyderabad
  • Kiran Aamir Associate professor, Pathology Department, Liaquat university of Medical and health sciences jamshoro Hyderabad
  • Aamir Ramzan Lecturer in pathology Department Liaquat university of Medical and health sciences jamshoro Hyderabad

Keywords:

anemia, highly active retroviral therapy (HAART), prevalence, severity, HIV

Abstract

Objective: This study was designed to determine the pattern of anaemia among HIV positive patients taking HAART. Study Design: Cross-sectional study. Place and Duration: Diagnostic and research Laboratory Liaquat university of Medical and health sciences Jamshoro, Hyderabad. January 2022-December 2022. Methods: Total 250 HIV patients (aged 18 years and above) of both genders taking HAART for at least the past six months. After taking written informed consent, data was recorded with the help of a structured questionnaire that contained questions regarding basic bio-data and medical history, along with the interpretation of general physical and systemic examination. A blood complete picture was done to evaluate baseline haematological parameters. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 22.0. Results: The mean age of the patients was 32.09 (±SD12.165). Most of the individuals, i.e., 160 (64%), were males, and the number of females was 90 (36%). The mean viral load was 2674.60. Anaemia was present in 210 (84%) patients and 40 (16%)non-anemic with standard parameters. Among anaemic patients, 130 52% had mild disease, moderate anaemia was found in 105 (42%), and only a few (n=15) 6% had severe anaemia. 

Downloads

Download data is not yet available.

References

Owiredu WKBA, Quaye L, Amidu N, Addai-Mensah O. Prevalence of anaemia and immunological markers among Ghanaian HAART-naïve HIV-patients and those on HAART. Afr Health Sci. 2011;11(1):2–15.

Jam S, Ramezani A, Sabzvari D, Moradmand-Badie B, SeyedAlinaghi SA, Jabbari H, et al. A cross-sectional study of anemia in human immunodeficiency virus-infected patients in Iran. Arch Iran Med. 2009;12(2):145–50.

Sullivan PS, Hanson DL, Chu SY, Jones JL, Ward JW. Epidemiology of anemia in human immunodeficiency virus (HIV)-infected persons: Results from the multistate adult and adolescent spectrum of HIV disease surveillance project. Blood. 1998;91(1):301–8.

Soldatov AA. Content of Methemoglobin in the Blood of Teleost Fish: Effect of Environmental Factors and Natural States of the Organism (Review). Inl Water Biol. 2021;14(6):747–57.

Gardner W, Kassebaum N. Global, Regional, and National Prevalence of Anemia and Its Causes in 204 Countries and Territories, 1990–2019. Curr Dev Nutr. 2020 Jun 1;4(Supplement_2):830–830.

Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann N Y Acad Sci. 2019 Apr 22;1450(1):15–31.

Thachil J, Owusu-Ofori S, Bates I. Haematological Diseases in the Tropics. A Checklist for Clinicians. In: Manson’s Tropical Diseases: Twenty-Third Edition. Elsevier; 2013. p. 894–932.

Gebremichael DY, Hadush KT, Kebede EM, Zegeye RT. Gender difference in health related quality of life and associated factors among people living with HIV/AIDS attending anti-retroviral therapy at public health facilities, western Ethiopia: Comparative cross sectional study. BMC Public Health. 2018;18(1).

Ikunaiye NY, Denue BA, Aina BA, Aderemi-Williams R, Rawizza HE. Incidence of Anaemia Among Hiv-Infected Patients Treated With Zidovudine-Containing Antiretroviral Therapy in Northeastern Nigeria. Ann Ibadan Postgrad Med. 2018;16(2):115–24.

Sah SK, Dahal P, Tamang GB, Mandal DK, Shah R, Pun SB. Prevalence and predictors of anemia in hiv-infected persons in nepal. HIV/AIDS - Res Palliat Care. 2020;12:193–200.

Virmani S, Bhat R, Rao R, Khanna R, Agarwal L. A rare cause of anaemia in HIV/AIDS. J Clin Diagnostic Res. 2017;11(8):OD01–2.

Jindal A, Mukherji S. World report on road traffic injury prevention. Med J Armed Forces India. 2005 Jan;61(1):91.

Wang D, Hou X, Yu X, Wang T, Ye Z, Li J, et al. Plasma hemoglobin and the risk of death in HIV/AIDS patients treated with antiretroviral therapy. Aging (Albany NY). 2021 May 15;13(9):13061–72.

14.Aynalem YA, Shibabaw Shiferaw W, Woldiye Z. Prevalence of Anemia and Its Associated Factors in Antiretroviral-Treated HIV/AIDS-Positive Adults from 2013 to 2018 at Debre Berhan Referral Hospital, Ethiopia. Adv Hematol. 2020 Mar 11;2020:1–7.

Tiewsoh JBA, Antony B, Boloor R. Seroprevalence of HIV-2 and dual infection among HIV-infected individuals with clinical and laboratory features at a Tertiary Care Teaching Hospital, Mangalore: The present scenario. Ann Afr Med. 2019;18(2):70–4.

Martin C, Poudel-Tandukar K, Poudel KC. HIV symptom burden and anemia among HIV-positive individuals: cross-sectional results of a community-based positive living with HIV (POLH) study in Nepal. PLoS One. 2014;9(12):e116263.

Santiago-Rodríguez EJ, Mayor AM, Fernández-Santos DM, Ruiz-Candelaria Y, Hunter-Mellado RF. Anemia in a cohort of HIV-infected Hispanics: Prevalence, associated factors and impact on one-year mortality. BMC Res Notes. 2014;7(1).

Gedefaw L, Yemane T, Sahlemariam Z, Yilma D. Anemia and Risk Factors in HAART Naïve and HAART Experienced HIV Positive Persons in South West Ethiopia: A Comparative Study. PLoS One. 2013;8(8).

Kulkarni MB, Bhalerao MM, Dube SP. Anemia in People Living With HIV/AIDS: A Cross Sectional Study from India. IOSR J Dent Med Sci. 2015;14(2):2279–861.

Obirikorang C, Issahaku RG, Osakunor DNM, Osei-Yeboah J. Anaemia and iron homeostasis in a cohort of HIV-infected patients: A cross-sectional study in Ghana. AIDS Res Treat. 2016;2016.

Gebremedhin KB, Haye TB. Factors Associated with Anemia among People Living with HIV/AIDS Taking ART in Ethiopia. Adv Hematol. 2019;2019.

Tadesse AW, Hemler EC, Andersen C, Passarelli S, Worku A, Sudfeld CR, et al. Anemia prevalence and etiology among women, men, and children in Ethiopia: A study protocol for a national population-based survey. BMC Public Health. 2019;19(1).

Habib MA, Black K, Soofi SB, Hussain I, Bhatti Z, Bhutta ZA, et al. Prevalence and predictors of iron deficiency anemia in children under five years of age in Pakistan, a secondary analysis of National Nutrition Survey data 2011-2012. PLoS One. 2016;11(5):e0155051.

Ali SA, Abbasi Z, Shahid B, Moin G, Hambidge KM, Krebs NF, et al. Prevalence and determinants of anemia among women of reproductive age in Thatta Pakistan: Findings from a cross-sectional study. PLoS One. 2020;15(9 September).

Wu Y, Ye H, Liu J, Ma Q, Yuan Y, Pang Q, et al. Prevalence of anemia and sociodemographic characteristics among pregnant and non-pregnant women in southwest China: A longitudinal observational study. BMC Pregnancy Childbirth. 2020 Sep 14;20(1).

Ali SA, Ali SA, Razzaq S, Khowaja N, Gutkind S, Raheman FU, et al. Predictors of iron consumption for at least 90 days during pregnancy: Findings from National Demographic Health Survey, Pakistan (2017–2018). BMC Pregnancy Childbirth. 2021 Dec 1;21(1).

Dionigi RA. Stereotypes of Aging: Their Effects on the Health of Older Adults. J Geriatr. 2015 Nov 12;2015:1–9.

Starks PT, Kelsey MMG, Rosania D, Getz WM. Does HIV infection increase male sexual behavior? Evol Med Public Heal. 2020 Jan 1;2020(1):174–80.

Sullivan PS, Hanson DL, Chu SY, Jones JL, Ward JW. Epidemiology of anemia in human immunodeficiency virus (HIV)-infected persons: Results from the multistate adult and adolescent spectrum of HIV disease surveillance project. Blood. 1998 Jan 1;91(1):301–8.

Volberding PA, Lagakos SW, Koch MA, Pettinelli C, Myers MW, Booth DK, et al. Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases. N Engl J Med. 1990;322(14):941–9.

Mocroft A, Kirk O, Barton SE, Dietrich M, Proenca R, Colebunders R, et al. Anaemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. AIDS. 1999 May;13(8):943–50.

Cosby C, Holzemer WL, Henry SB, Portillo CJ. Hematological complications and quality of life in hospitalized AIDS patients. AIDS Patient Care STDS. 2000;14(5):269–79.

Randi ML, Bertozzi I, Santarossa C, Cosi E, Lucente F, Bogoni G, et al. Prevalence and causes of anemia in hospitalized patients: Impact on diseases outcome. J Clin Med. 2020 Mar 30;9(4):950.

Belachew A, Tewabe T, Malede GA. Prevalence of vertical HIV infection and its risk factors among HIV exposed infants in East Africa: a systematic review and meta-analysis. Trop Med Health. 2020;48(1).

Getaneh Z, Wale W, Chanie B, Temesgen E, Abebe M, Walie M, et al. Magnitude and associated factors of anemia among AZT based HAART experienced adult HIV patients at University of Gondar Comprehensive Specialized Referral Hospital, Northwest, Ethiopia, 2019: a retrospective cohort study. BMC Infect Dis. 2021;21(1).

Berhane Y, Haile D, Tolessa T. Anemia in hiv/aids patients on antiretroviral treatment at ayder specialized hospital, Mekele, Ethiopia: A case-control study. J Blood Med. 2020;11:379–87.

Wagnew F, Eshetie S, Alebel A, Tesema C, Kibret GD, Gebrie A, et al. Burden of anemia and its association with HAART in HIV infected children in Ethiopia: A systematic review and meta-analysis. BMC Infect Dis. 2019;19(1):1032.

Tsegay YG, Tadele A, Addis Z, Alemu A, Melku M. Magnitude of cytopenias among HIV-infected children in Bahir Dar, northwest Ethiopia: A comparison of HAART-naïve and HAART-experienced children. HIV/AIDS - Res Palliat Care. 2017;9:31–42.

Published

27-06-2023

How to Cite

Devi, D., Khan, M. R., Khan, A., Kumar, S., Anique, M., Sidrah, S., Aamir, K., & Ramzan, A. (2023). Pattern of anemia and associated parameters in HIV positive patients taking highly active retroviral therapy (HAART). International Journal of Health Sciences, 7(S1), 1748–1759. https://doi.org/10.53730/ijhs.v7nS1.14408

Issue

Section

Peer Review Articles

Most read articles by the same author(s)