Comparison of C - reactive protein and erythrocyte sedimentation rate biomarkers for identification of immunological disorders in Tertiary Care Hospital

https://doi.org/10.53730/ijhs.v7nS1.14608

Authors

  • Muhammad Abbas Department of Medical Laboratory IPMS Peshawar
  • Samiul Haq Department of Health and Biological Sciences Abasyn University Peshawar
  • Ishaq Safi Department of Medical Laboratory Life Care International Hospital Islamabad
  • Majid Khan Department of Health and Biological Sciences Abasyn University Peshawar
  • Muhammad Hassan Khan Department of Medical Laboratory Al Khidmat Hospital Peshawar
  • Aziz ur Rehman Department of Health and Biological Sciences Abasyn University Peshawar
  • Abdullah Khan Department of Biochemistry Abdul Wali Khan University Peshawar

Keywords:

A c-reactive protein, ESR (erythrocyte sedimentation rate), anti-rheumatic arthritis activity

Abstract

Background: In this exploratory study, a cross-comparison was made between CRP, ESR, RA-Factor, and ASO tests for 300 individuals of both males and females in tertiary care hospitals to find an association that is not identified through the immunological marker. The quantitative approach was utilized to check the high ESR rate for an individual who has a positive CRP. The data were analyzed using SPSS version 25. Results: suggest that CRP and ESR play a role in patients with immunological disorders, and a significant relationship was identified between CRP and ESR. The mean and standard deviation of CRP were n=1.4 ± 0.4, ESR 25 ± 15.9 mm/minute, n =RA-Factor 1.6 ± 0.4, and ASO 1.3 ± 0.4, respectively CRP are mostly positive in serological disorders. Linear regression showed a strong positive association between ESR and CRP, with a significant P value less than 0.05.

Downloads

Download data is not yet available.

References

Anderson, Marsha S, Burns, Jennifer, Treadwell, Tracee A, Pietra, Biagio A, & Glode, Mary P. (2001). Erythrocyte sedimentation rate and C-reactive protein discrepancy and high prevalence of coronary artery abnormalities in Kawasaki disease. The Pediatric infectious disease journal, 20(7), 698-702.

Batlivala, Sarosh P. (2009). The erythrocyte sedimentation rate and the c-reactive protein test. Pediatrics in Review, 30(2).

Bitik, Berivan, Mercan, Rıdvan, Tufan, Abdurrahman, Tezcan, Engin, Küçük, Hamit, İlhan, Mustafa, . . . Göker, Berna. (2015). Differential diagnosis of elevated erythrocyte sedimentation rate and C-reactive protein levels: a rheumatology perspective. European Journal of Rheumatology, 2(4), 131.

Boutel, Maria, Boutou, Afroditi, Pitsiou, Georgia, Garyfallos, Alexandros, & Dimitroulas, Theodoros. (2023). Efficacy and Safety of Nintedanib in Patients with Connective Tissue Disease-Interstitial Lung Disease (CTD-ILD): A Real-World Single Center Experience. Diagnostics, 13(7), 1221.

Bray, Christopher, Bell, Lauren N, Liang, Hong, Haykal, Rasha, Kaiksow, Farah, Mazza, Joseph J, & Yale, Steven H. (2016). Erythrocyte sedimentation rate and C-reactive protein measurements and their relevance in clinical medicine. Wmj, 115(6), 317-321.

Cha, Choong-Hwan, Park, Chan-Jeoung, Cha, Young Joo, Kim, Hyun Kyung, Kim, Duck Hee, Bae, Jae Hoon, . . . Lee, Dong Soon. (2009). Erythrocyte sedimentation rate measurements by TEST 1 better reflect inflammation than do those by the Westergren method in patients with malignancy, autoimmune disease, or infection. American Journal of Clinical Pathology, 131(2), 189-194.

Chan, Fiona Li Ying, Lester, Susan, Whittle, Samuel Lawrence, & Hill, Catherine Louise. (2019). The utility of ESR, CRP, and platelets in the diagnosis of GCA. BMC rheumatology, 3, 1-7.

Çiftel, Serpil, & Tüzün, Zeynep. (2023). Could the Systemic Immune Inflammation Index Predict Diagnosis, Recovery Time, Hypothyroidism, and Recurrence Rates in Subacute Thyroiditis? International Journal of General Medicine, 1375-1382.

Desai, D, Faubion, WA, & Sandborn, WJ. (2007). biological activity markers in inflammatory bowel disease. Alimentary pharmacology & therapeutics, 25(3), 247-255.

Fayed, Hala L, Shahin, Amira A, El-Bohy, Abo El-Magd M, & Younis, Sahar S. (2023). Comparative assessment of hepatitis C virus-related arthritis and rheumatoid arthritis: Relation to clinical, serologic and ultrasonographic characteristics. The Egyptian Rheumatologist, 45(3), 213-218.

George, Michael, & Mukherjee, Rajarshi. (2023). Prognostic Serum Biomarkers of Inflammaging in Patients Undergoing Emergency Laparotomy. Journal of Personalized Medicine, 13(5), 769.

Hwang, Mark, Assassi, Shervin, Zheng, Jim, Castillo, Jessica, Chavez, Reyna, Vanarsa, Kamala, . . . Reveille, John. (2023). Quantitative proteomic screening uncovers candidate diagnostic and monitoring serum biomarkers of ankylosing spondylitis. Arthritis Research & Therapy, 25(1), 57.

Lapić, Ivana, Padoan, Andrea, Bozzato, Dania, & Plebani, Mario. (2020). Erythrocyte sedimentation rate and C-reactive protein in acute inflammation: meta-analysis of diagnostic accuracy studies. American Journal of Clinical Pathology, 153(1), 14-29.

Lavery, Lawrence A, Ahn, Junho, Ryan, Easton C, Bhavan, Kavita, Oz, Orhan K, La Fontaine, Javier, & Wukich, Dane K. (2019). What are the optimal cutoff values for ESR and CRP to diagnose osteomyelitis in patients with diabetes-related foot infections? Clinical Orthopaedics and Related Research, 477(7), 1594.

Lucius, Khara. (2023). Novel and Emerging Markers of Chronic or Low-Grade Inflammation. Integrative and Complementary Therapies, 29(3), 130-142.

Pelassa, Simone, Raggi, Federica, Rossi, Chiara, & Bosco, Maria Carla. (2023). MicroRNAs in Juvenile Idiopathic Arthritis: State of the Art and Future Perspectives. Biology, 12(7), 991.

Saadeh, C. (1998). The erythrocyte sedimentation rate: old and new clinical applications. Southern Medical Journal-Birmingham Alabama-, 91, 219-226.

Sami ul haq310 : Cha, Choong-Hwan, Park, Chan-Jeoung, Cha, Young Joo, Kim, Hyun Kyung, Kim, Duck Hee, Honghoon, . . . Chi, Hyun-Sook. (2009). Erythrocyte sedimentation rate measurements by TEST 1 better reflect inflammation than do those by the Westergren method in patients with malignancy, autoimmune disease, or infection. American Journal of Clinical Pathology, 131(2), 189-194.

Sonia, Sanjida Pervin, Ferdous, Ellen, Islam, Mohammad Imnul, & Rahman, Shahana Akhter. (2023). Neutrophil Count, Platelet Indices, CRP and Their Association with Disease Activity of Juvenile Idiopathic Arthritis (JIA): A Study from Bangladesh. Open Journal of Rheumatology and Autoimmune Diseases, 13(1), 41-49.

Sproston, Nicola R, & Ashworth, Jason J. (2018). Role of C-reactive protein at sites of inflammation and infection. Frontiers in immunology, 9, 754.

Published

18-11-2023

How to Cite

Abbas, M., Haq, S., Safi, I., Khan, M., Khan, M. H., Rehman, A. U., & Khan, A. (2023). Comparison of C - reactive protein and erythrocyte sedimentation rate biomarkers for identification of immunological disorders in Tertiary Care Hospital. International Journal of Health Sciences, 7(S1), 2985–2992. https://doi.org/10.53730/ijhs.v7nS1.14608

Issue

Section

Peer Review Articles