Indian gooseberry (Emblica officinalis Gaertn) drink spiked with spices-Immunomodulatory properties
Keywords:
Indian gooseberry, 2-galloyl glucose, capsaicinoids, WBC, bone marrow cellularity, curcuminoidsAbstract
Indian gooseberry juice (20% (v/v) was reconstituted with 5% ginger juice (v/v) extracted from freshly harvested rhizomes, 2% each of turmeric rhizome powder and black pepper powder (w/v), followed by raising the total soluble solids to 130Brix by adding sugar syrup. Finally, 5% acid lime juice of 2.45% of titratable citric acid was added to the entire mixture in order to impart a fruity flavour to the product. The entire mixture was homogenized at 175 Bar (2500 psi) with a speed of 235 rpm and was subsequently pasteurized at 1000C for 10 minutes. LC-MS/MS analysis detected phenolic compounds (2-galloyl glucose, 2,6-galloyl glucose), capsaicinoids, curcuminoids, gingerol and shogaol. Though cyclophosphamide significantly inhibited the relative weight of thymus from 0.193 ± 0.048 in normal mice to 0.077 ± 0.034, treatment with the herbal drink significantly increased the relative weight of thymus, showing increased T cell differentiation. Mice treated with the drink showed marginal increase in the WBC count, indicating recovery of immunity. Recovery of bone marrow cellularity in mice fed with the herbal drink was directly proportional to the concentration of the drink. Increase in a-esterase activity was also directly proportional to the concentration of herbal beverage.
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Agbor, G.A.L., Akinfiresoye, J., Sortino, J.R., Johnson, R., & Vinson, J.A. (2012).
AOAC. (1998). Official method of analysis of AOAC International (16 Ed.). Association of Official Agricultural Chemists, Washington DC, p899
Balcells, F., Martínez Monteros, M.J., Gómez, A.L., Cazorla, S.I., Perdigón, G., & Maldonado-Galdeano, C. (2022). Probiotic Consumption Boosts Thymus in Obesity and Senescence Mouse Models. Nutrients, 14, 616.https://doi.org/10.3390/nu14030616
Bancroft, J.D., & Cook, H.F. (1992). Manual of Histologic Techniques. London: Churchill Livingstone, pp. 171–174
Bischoff-Kont, I.and Furst, R. (2021). Benefits of ginger and its constituent 6- shogaol in inhibiting inflammatory processes.Pharmaceuticals.14 (6):1-19.
Bodagh, M.N., Maleki, I. And Hekmatdoost, A.(2019). Ginger in gastrointestinal disorders: a systematic review of clinical trials. Food Science and Nutrition. 7(1): 96-108.
Bode, A.M., & Dong, Z. (2011).The Amazing and Mighty Ginger. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis British Journal of Nutrition, 88(S2), S165-S176. https://doi.org/10. 1079/bjn2002682
Calder, P.C., & Kew, S. (2002). The immune system: A target for functional foods? British Journal of Nutrition. 88 2:S165-77. doi: 10.1079/BJN2002682. PMID: 12495459.
Chakraborty, S., Bhalerao, P.P., Mahale, S.A., & Dhar, R. (2020). Optimizing the formulation for a pomegranate-amla-muskmelon based mixed fruit beverage using sensory analysis and evaluating its thermal stability. LWT- Food Science and Technology, 133, 109907. https://doi.org/10.1016/j.lwt.2020.109907
Crocker, P.R., Paulson, J.C. and Varki, A. (2007). Siglecs and their roles in the immune system. Nature Reviews Immunology, 7(4): 255-266.
Das, K. (2022). Herbal plants as immunity modulators against COVID-19: A primary preventive measure during home quarantine. Journal of Herbal Medicine, Mar; 32:100501. doi: 10.1016/j.hermed.2021.100501
Delecroix, B., Abaïdia, A.E., Leduc, C., Dawson, B., Dupont, G., Nelson, K.M., Dahlin, J.L., Bisson, J., Graham, J., Pauli, G.F., & Walters, M.A. (2017). The Essential Medicinal Chemistry of Curcumin: Miniperspective. Journal of Medicinal Chemistry, 60: 1620–1637
Gomez, S., Anjali, C., Kuruvila, B., Maneesha, P.K., & Joseph, M. (2023).Phytochemical constitution and antioxidant activity of functional herbal drink from Indian gooseberry (Emblica officinalis Gaertn.) fruits containing spices and condiments. Food Prod Process and Nutr 5, 12 (2023). https://doi.org/10.1186/s43014-022-00127-8
Gul, M., Liu, Z.W., Rabail, R., Faheem, F., Walayat, N., Nawaz, A., Shabbir, M.A., Munekata, P.E., Lorenzo, J.M. and Aadil, R.M.(2022). Functional and nutraceutical significance of Amla (Phyllanthus emblica L.): a review. Antioxidants, 11(5): 1-15.
Halyorsen, B.L., Holte, K., Myhrstad, M.C., Barikmo, I., Hvattum, E., Remberg, S.F., Wold, A.B., Haffner, K., Baugerød, H., & Andersen Moskaug, L.F. (2002). A systematic screening of total antioxidants in dietary plants. Journal of Nutrition 132(3), 461-471. https://doi.org/10.1093/jn/132.3.461
Haque, R., Bin-Hafeez, B., Ahmad, I., Parvez, S., Pandey, S., & Raisuddin, S. (2001). Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. Human & Experimental Toxicology, 20(12), 643-650. https://doi.org/10.1191/096032701718890568
Haslberger, A.G., Jakob, U., Hippe, B., & Karlic, H. (2020). Mechanisms of selected functional foods against viral infections with a view on COVID-19; Mini review. Functional Foods in Health and Disease, 10(5); 195-209. https://doi.org/10.31989/ffhd.v10i5.707
Hayat, K., Iqbal, H., Malik, U., Bilal, U., & Mushtaq, S. (2015). Tea and its consumption: benefits and risks. Critical Reviews in Food Science and Nutrition, 55, 939–954. https://doi.org/10.1080/10408398.2012.678949
He, C., Miyazawa, T., Abe,C., Ueno, T., Suzuki, M., Mizukami, M., Kurihara, K. and Toda, M.(2023). International Journal of Molecular Sciences. 24(11):1-14
Hewlings, J.S., & Kalman, D.S. (2017). Curcumin: A review on its effects on human health. Foods, (2017) 6, 92; doi: 10.3390/foods6100092
Ishwarya, M., & Narendhirakannan, R.T. (2017). 3, 4 Dihydroxycinnamic acid stimulates immune system function by modifying the humoral antibody response – An in vivo study. Cellular Immunology, 314:10-17. ttp://dx.doi.org/10.1016/j.cellimm.2017.01.006
Izui,S., Sekine, S., Maeda, K., Kuboniwa, M., Takada, A., Amano, A. and Nagata, H.(2016). Antibacterial activity of curcumin against periodontopathic bacteria. Journal of Periodontology 87(1): 83-90.
Jiang, L., Zhang, G., Li, Y., Shi, G & Li, M. (2021). Potential Application of Plant-Based Functional Foods in the Development of Immune Boosters. Frontiers in Pharmacology, 12:637782.doi: 10.3389/fphar.2021.637782
Keservani, R.K., Kesharwani, R.K., Vyas, N., Jain, S., Raghuvanshi, R., & Sharma, A.K. (2010). “Nutraceutical and Functional Food as Future Food: A Review”, Der Pharmacia Lettre, 2 (1): 106-116
Lao, C.D., Ruffin, M.T., Normolle, D., Heath, D.D., Murray, S., Bailey, J.M., Boggs, M.E., Crowell, J., Rock, C.L., & Brenner, D.E. (2006). Dose escalation of a curcuminoid formulation. BMC Complementary and Alternative Medicine, 1, 6, 10
Luo, X.J. Peng, J. and Li, Y.J.(2011). Recent advances in the study on capsaicinoids and capsinoids. European Journal of Pharmacology. 650(1):1-7.
Maheshwari, S., Kumar, V., Bhadauria, G., & Mishra, A. (2022). Immunomodulatory potential of phytochemicals and other bioactive compounds of fruits: A review. Food Frontiers, 3, 221– 238. https://doi.org/10.1002/fft2.129
Mishra, L. K., & Sangma, D. (2017). Quality attributes, phytochemical profile and storage stability studies of functional ready to serve (RTS) drink made from blend of Aloe vera, sweet lime, amla and ginger. Journal of Food Science & Technology, 54(3), 761–769. https://doi.org/10.1007/s13197-017-2516-9.
Nweze, C.C., Yako, A.B., Uzoukwu, A.E., & Rasaq, N.O. (2015). Effect of antioxidant nutraceuticals and functional foods on blood serum and immune activation of HIV infected patients in Abuja, Nigeria. International Journal of Innovative Science, Engineering & Technology, 2 (2), 148-155
Okwute, S.K. and Egharevba, H.O.(2013). Piperine-type amides: review of the chemical and biological characteristics. International Journal of Chemistry, 5(3):99-122.
Osorio, E.Y., Gugala, Z., Patterson, G.T., Palacios, G., Cordova, E., Uscanga-Palomeque, A., Travi, B.L., & Melby, P.C. (2022). Inflammatory stimuli alter bone marrow composition and compromise bone health in the malnourished host. Frontiers in Immunology, 13:846246. doi: 10.3389/fimmu.2022.846246
Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters. Food Chemistry, 134: 1354-1359
Priya, M.D., & Khatkar, B.S. (2013). Effect of processing method on keeping quality of aonla preserve. International Food Research Journal, 20(2):617- 622
Rekha, P.S., Kuttan, G., & Kuttan, R. (2000). Effect of herbal preparation, brahma rasayana, in amelioration of radiation induced damage. Indian Journal of Experimental Biology, 38: 999-1002
Sahebkar, A., Serbanc, M.C., Ursoniuc, S., & Banach, M. (2015). Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Journal of Functional Foods, 18, 898–909
Sai Ram, M.., Neetu, D., Yogesh, B., Anju, B., Dipti, P., Pauline, T., Sharma, S.K., Sarada, S.K.S., Ilavazhagan, G., Kumar, D., & Selvamurthy, W. (2002). Cyto-protective and immunomodulating properties of amla (Emblica officinalis) on lymphocytes: An in-vitro study. Journal of Ethnopharmacology, 81(1), 5-10. https://doi.org/10.1016/s0378-8741(01)00421-4
Shahrajabian, M.H., Sun, W. and Cheng, Q. (2019). Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry. Acta agriculturae scandinavica, section b—Soil & Plant Science, 69(6): 546-556.
Singh, M. K., Yadav, S.S., Gupta, V., & Khattri, S. (2013). Immunomodulatory role of Emblica officinalis in arsenic induced oxidative damage and apoptosis in thymocytes of mice. BMC Complementary and Alternative Medicine, 13, 193. https://doi.org/10.1186/1472-6882-13-193
Sredni, B.M., Albeck, G., Kazimmirsky, F., & Shalet. (1992).The immunomodulator administered orally as a radio protective agent. International Journal of lmmunopharmacology, 14, 619
Tadokoro, Y., & Hirao, A. (2022). The Role of Nutrients in Maintaining Hematopoietic Stem Cells and Healthy Hematopoiesis for Life. International Journal of Molecular Sciences, 23, 1574. https://doi.org/10.3390/ijms23031574
Thongin, S., Den-Udom, T., Uppakara, K., Sriwantana, T., Sibmooh, N., Laolob, T., Boonthip, C., Wichai, U., Muta, K. and Ketsawatsomkron, P. (2022). Beneficial effects of capsaicin and dihydrocapsaicin on endothelial inflammation, nitric oxide production and antioxidant activity. Biomedicine & Pharmacotherapy. 153:1-10.
Vo, T.S., Vo, T.T.B.C., Vo, T.T.T.N. and Lai, T.N.H. (2021). Turmeric (Curcuma longa L.): Chemical components and their effective clinical applications. Journal of the Turkish Chemical Society Section A: Chemistry, 8(3):883-898.
Walker, B.C. and Mittal, S. (2020). Antitumor activity of curcumin in glioblastoma. International Journal of Molecular Sciences. 21(24):1-11.
Yu, L., Hu, X., Xu, R., Ba, Y., Chen, X., Wang, X., Cao, B., & Wu, X. (2022). Amide alkaloids characterization and neuroprotective properties of Piper nigrum L.: a comparative study with fruits, pericarp, stalks and leaves. Food Chemistry. 368:130832. https://doi.org/10.1016/j.foodchem.2021.130832
Zak, A & Pokora, I. (2017). Effect of long-term green tea extract supplementation on peripheral blood leukocytes in cross-fit trained and untrained men. Central European Journal of Sport Sciences and Medicine, 19 (3), 67-76. DOI: 10.18276/cej.2017.3-06
Zhao, T., Sun, Q., Marques, M., & Witcher, M. (2015). Anticancer properties of Phyllanthus emblica (Indian Gooseberry). Oxidative Medicine and Cellular Longevity, 1-7. https://doi.org/10.1155/2015/950890
Zick , S.M., Djuric , Z., Ruffin , M.T., Litzinger , A.J., Normolle , D.P., Alrawi, S., Feng , M.R., & Brenner, D.E. (2008). Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol, and conjugate metabolites in healthy human subjects. Cancer Epidemiology, Biomarkers and Prevention, 17 (8): 1930-6. doi: 10.1158/1055-9965.EPI-07-2934
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