Addressing acute gastrointestinal emergencies: From hemorrhage to obstruction

https://doi.org/10.53730/ijhs.v3nS1.15137

Authors

  • Sultan Mohammed Alanazi KSA, National Guard Health Affairs
  • Hatim Faihan Alotaibi KSA, National Guard Health Affairs
  • Ibrahim Mohammed Alanazi KSA, National Guard Health Affairs
  • Adel Mohammad Aldukhain KSA, National Guard Health Affairs
  • Salman Abdullah Alharbi KSA, National Guard Health Affairs
  • Hamoud Ghayyadh Alanizi KSA, National Guard Health Affairs
  • Fayez Abdullah Hussain Alsari KSA, National Guard Health Affairs
  • Rayan Salem Abdulaziz Alghufaili KSA, National Guard Health Affairs
  • Sulaiman Ahmed Almansour KSA, National Guard Health Affairs

Keywords:

Gastrointestinal bleeding, lower gastrointestinal bleeding, colonoscopy, predictive models, risk stratification, early intervention

Abstract

Background: Gastrointestinal bleeding (GIB) has traditionally been divided into upper and lower gastrointestinal bleeding (UGIB and LGIB). Advances in diagnostic technologies, including capsule endoscopy and balloon-assisted enteroscopy, have refined our understanding of small bowel bleeding, leading to a revised classification system encompassing upper, mid, and lower GIB. The rising incidence of LGIB is attributed to an aging population and increased antithrombotic use. Despite improvements in UGIB management, effective preventive strategies for LGIB remain insufficient, with significant hospitalization and mortality rates. Aim: This review aims to consolidate current knowledge on the initial management of acute LGIB, addressing advancements in predictive scoring systems, risk stratification, and the role of early colonoscopy. Methods: A comprehensive literature review was conducted, focusing on recent advancements and guidelines, including the 2016 American College of Gastroenterology guidelines for acute LGIB and the American Society for Gastrointestinal Endoscopy guidelines on antithrombotic management. Results: The review highlights the challenges in managing acute LGIB, including the diverse etiology of bleeding, the need for effective risk stratification tools, and the optimization of colonoscopy timing. New predictive models, such as the NOBLADS score and other risk scoring systems, provide valuable insights into severe LGIB outcomes. 

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References

Gunjan D, Sharma V, Rana SS, Bhasin DK. Small bowel bleeding: a comprehensive review. Gastroenterol Rep (Oxf) 2014;2:262–275. DOI: https://doi.org/10.1093/gastro/gou025

Lanas A, García-Rodríguez LA, Polo-Tomás M, Ponce M, Alonso-Abreu I, Perez-Aisa MA, Perez-Gisbert J, Bujanda L, Castro M, Muñoz M, Rodrigo L, Calvet X, Del-Pino D, Garcia S. Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol. 2009;104:1633–1641. DOI: https://doi.org/10.1038/ajg.2009.164

Lanas A, García-Rodríguez LA, Polo-Tomás M, Ponce M, Quintero E, Perez-Aisa MA, Gisbert JP, Bujanda L, Castro M, Muñoz M, Del-Pino MD, Garcia S, Calvet X. The changing face of hospitalisation due to gastrointestinal bleeding and perforation. Aliment Pharmacol Ther. 2011;33:585–591. DOI: https://doi.org/10.1111/j.1365-2036.2010.04563.x

Nagata N, Niikura R, Aoki T, Shimbo T, Itoh T, Goda Y, Suda R, Yano H, Akiyama J, Yanase M, Mizokami M, Uemura N. Increase in colonic diverticulosis and diverticular hemorrhage in an aging society: lessons from a 9-year colonoscopic study of 28,192 patients in Japan. Int J Colorectal Dis. 2014;29:379–385. DOI: https://doi.org/10.1007/s00384-013-1808-4

Laine L, Yang H, Chang SC, Datto C. Trends for incidence of hospitalization and death due to GI complications in the United States from 2001 to 2009. Am J Gastroenterol. 2012;107:1190–1195; quiz 1196. DOI: https://doi.org/10.1038/ajg.2012.168

Hreinsson JP, Gumundsson S, Kalaitzakis E, Björnsson ES. Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting. Eur J Gastroenterol Hepatol. 2013;25:37–43. DOI: https://doi.org/10.1097/MEG.0b013e32835948e3

Strate LL, Ayanian JZ, Kotler G, Syngal S. Risk factors for mortality in lower intestinal bleeding. Clin Gastroenterol Hepatol. 2008;6:1004–1010; quiz 955. DOI: https://doi.org/10.1016/j.cgh.2008.03.021

Niikura R, Yasunaga H, Yamaji Y, Horiguchi H, Fushimi K, Yamada A, Hirata Y, Koike K. Factors affecting in-hospital mortality in patients with lower gastrointestinal tract bleeding: a retrospective study using a national database in Japan. J Gastroenterol. 2015;50:533–540. DOI: https://doi.org/10.1007/s00535-014-0994-3

Oakland K, Guy R, Uberoi R, Hogg R, Mortensen N, Murphy MF, Jairath V; UK Lower GI Bleeding Collaborative. Acute lower GI bleeding in the UK: patient characteristics, interventions and outcomes in the first nationwide audit. Gut. 2018;67:654–662. DOI: https://doi.org/10.1136/gutjnl-2016-313428

Anthony T, Penta P, Todd RD, Sarosi GA, Nwariaku F, Rege RV. Rebleeding and survival after acute lower gastrointestinal bleeding. Am J Surg. 2004;188:485–490. DOI: https://doi.org/10.1016/j.amjsurg.2004.07.020

Aoki T, Nagata N, Niikura R, Shimbo T, Tanaka S, Sekine K, Kishida Y, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N. Recurrence and mortality among patients hospitalized for acute lower gastrointestinal bleeding. Clin Gastroenterol Hepatol. 2015;13:488–494.e1. DOI: https://doi.org/10.1016/j.cgh.2014.06.023

Mohammed Ilyas MI, Szilagy EJ. Management of Diverticular Bleeding: Evaluation, Stabilization, Intervention, and Recurrence of Bleeding and Indications for Resection after Control of Bleeding. Clin Colon Rectal Surg. 2018;31:243–250. DOI: https://doi.org/10.1055/s-0037-1607963

Strate LL, Gralnek IM. ACG Clinical Guideline: Management of Patients With Acute Lower Gastrointestinal Bleeding. Am J Gastroenterol. 2016;111:459–474. DOI: https://doi.org/10.1038/ajg.2016.41

ASGE Standards of Practice Committee, Acosta RD, Abraham NS, Chandrasekhara V, Chathadi KV, Early DS, Eloubeidi MA, Evans JA, Faulx AL, Fisher DA, Fonkalsrud L, Hwang JH, Khashab MA, Lightdale JR, Muthusamy VR, Pasha SF, Saltzman JR, Shaukat A, Shergill AK, Wang A, Cash BD, DeWitt JM. The management of antithrombotic agents for patients undergoing GI endoscopy. Gastrointest Endosc. 2016;83:3–16. DOI: https://doi.org/10.1016/j.gie.2015.09.035

Srygley FD, Gerardo CJ, Tran T, Fisher DA. Does this patient have a severe upper gastrointestinal bleed? JAMA. 2012;307:1072–1079. DOI: https://doi.org/10.1001/jama.2012.253

Sittichanbuncha Y, Senasu S, Thongkrau T, Keeratikasikorn C, Sawanyawisuth K. How to differentiate sites of gastrointestinal bleeding in patients with hematochezia by using clinical factors? Gastroenterol Res Pract. 2013;2013:265076. DOI: https://doi.org/10.1155/2013/265076

Gralnek IM, Neeman Z, Strate LL. Acute Lower Gastrointestinal Bleeding. N Engl J Med. 2017;376:1054–1063. DOI: https://doi.org/10.1056/NEJMcp1603455

Morkar DN, Hazare S. Spectrum of the causes of lower gastrointestinal bleeding in geriatric patients in tertiary care hospital. J Sci Soc. 2017;44:148–151. DOI: https://doi.org/10.4103/jss.JSS_17_16

Nagata N, Niikura R, Aoki T, Shimbo T, Kishida Y, Sekine K, Tanaka S, Okubo H, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N. Natural history of outpatient-onset ischemic colitis compared with other lower gastrointestinal bleeding: a long-term cohort study. Int J Colorectal Dis. 2015;30:243–249. DOI: https://doi.org/10.1007/s00384-014-2079-4

Kollef MH, O’Brien JD, Zuckerman GR, Shannon W. BLEED: a classification tool to predict outcomes in patients with acute upper and lower gastrointestinal hemorrhage. Crit Care Med. 1997;25:1125–1132. DOI: https://doi.org/10.1097/00003246-199707000-00011

Strate LL, Orav EJ, Syngal S. Early predictors of severity in acute lower intestinal tract bleeding. Arch Intern Med. 2003;163:838–843. DOI: https://doi.org/10.1001/archinte.163.7.838

Das A, Ben-Menachem T, Cooper GS, Chak A, Sivak MV Jr, Gonet JA, Wong RC. Prediction of outcome in acute lower-gastrointestinal haemorrhage based on an artificial neural network: internal and external validation of a predictive model. Lancet. 2003;362:1261–1266. DOI: https://doi.org/10.1016/S0140-6736(03)14568-0

Velayos FS, Williamson A, Sousa KH, Lung E, Bostrom A, Weber EJ, Ostroff JW, Terdiman JP. Early predictors of severe lower gastrointestinal bleeding and adverse outcomes: a prospective study. Clin Gastroenterol Hepatol. 2004;2:485–490. DOI: https://doi.org/10.1016/S1542-3565(04)00167-3

Aoki T, Nagata N, Shimbo T, Niikura R, Sakurai T, Moriyasu S, Okubo H, Sekine K, Watanabe K, Yokoi C, Yanase M, Akiyama J, Mizokami M, Uemura N. Development and Validation of a Risk Scoring System for Severe Acute Lower Gastrointestinal Bleeding. Clin Gastroenterol Hepatol. 2016;14:1562–1570.e2. DOI: https://doi.org/10.1016/j.cgh.2016.05.042

Newman J, Fitzgerald JE, Gupta S, von Roon AC, Sigurdsson HH, Allen-Mersh TG. Outcome predictors in acute surgical admissions for lower gastrointestinal bleeding. Colorectal Dis. 2012;14:1020–1026. DOI: https://doi.org/10.1111/j.1463-1318.2011.02824.x

Chong V, Hill AG, MacCormick AD. Accurate triage of lower gastrointestinal bleed (LGIB) - A cohort study. Int J Surg. 2016;25:19–23. DOI: https://doi.org/10.1016/j.ijsu.2015.11.003

Oakland K, Jairath V, Uberoi R, Guy R, Ayaru L, Mortensen N, Murphy MF, Collins GS. Derivation and validation of a novel risk score for safe discharge after acute lower gastrointestinal bleeding: a modelling study. Lancet Gastroenterol Hepatol. 2017;2:635–643 DOI: https://doi.org/10.1016/S2468-1253(17)30150-4

Sengupta N, Tapper EB. Derivation and Internal Validation of a Clinical Prediction Tool for 30-Day Mortality in Lower Gastrointestinal Bleeding. Am J Med. 2017;130:601.e1–601.e8. DOI: https://doi.org/10.1016/j.amjmed.2016.12.009

Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38:316–321. DOI: https://doi.org/10.1136/gut.38.3.316

Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet. 2000;356:1318–1321. DOI: https://doi.org/10.1016/S0140-6736(00)02816-6

Baradarian R, Ramdhaney S, Chapalamadugu R, Skoczylas L, Wang K, Rivilis S, Remus K, Mayer I, Iswara K, Tenner S. Early intensive resuscitation of patients with upper gastrointestinal bleeding decreases mortality. Am J Gastroenterol. 2004;99:619–622. DOI: https://doi.org/10.1111/j.1572-0241.2004.04073.x

Kwan I, Bunn F, Chinnock P, Roberts I. Timing and volume of fluid administration for patients with bleeding. Cochrane Database Syst Rev. 2014:CD002245 DOI: https://doi.org/10.1002/14651858.CD002245.pub2

Perel P, Roberts I, Ker K. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2013:CD000567. DOI: https://doi.org/10.1002/14651858.CD000567.pub6

Odutayo A, Desborough MJ, Trivella M, Stanley AJ, Dorée C, Collins GS, Hopewell S, Brunskill SJ, Kahan BC, Logan RF, Barkun AN, Murphy MF, Jairath V. Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials. Lancet Gastroenterol Hepatol. 2017;2:354–360. DOI: https://doi.org/10.1016/S2468-1253(17)30054-7

Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ, Srinivas V, Menegus MA, Marroquin OC, Rao SV, Noveck H, Passano E, Hardison RM, Smitherman T, Vagaonescu T, Wimmer NJ, Williams DO. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J. 2013;165:964–971.e1. DOI: https://doi.org/10.1016/j.ahj.2013.03.001

Docherty AB, O’Donnell R, Brunskill S, Trivella M, Doree C, Holst L, Parker M, Gregersen M, Pinheiro de Almeida J, Walsh TS, Stanworth SJ. Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. BMJ. 2016;352:i1351. DOI: https://doi.org/10.1136/bmj.i1351

Razzaghi A, Barkun AN. Platelet transfusion threshold in patients with upper gastrointestinal bleeding: a systematic review. J Clin Gastroenterol. 2012;46:482–486. DOI: https://doi.org/10.1097/MCG.0b013e31823d33e3

Contreras M. Final statement from the consensus conference on platelet transfusion. Transfusion. 1998;38:796–797. DOI: https://doi.org/10.1046/j.1537-2995.1998.38898375520.x

Jensen DM, Machicado GA, Jutabha R, Kovacs TO. Urgent colonoscopy for the diagnosis and treatment of severe diverticular hemorrhage. N Engl J Med. 2000;342:78–82. DOI: https://doi.org/10.1056/NEJM200001133420202

Jensen DM, Ohning GV, Kovacs TO, Jutabha R, Ghassemi K, Dulai GS, Machicado GA. Natural history of definitive diverticular hemorrhage based on stigmata of recent hemorrhage and colonoscopic Doppler blood flow monitoring for risk stratification and definitive hemostasis. Gastrointest Endosc. 2016;83:416–423. DOI: https://doi.org/10.1016/j.gie.2015.07.033

Green BT, Rockey DC, Portwood G, Tarnasky PR, Guarisco S, Branch MS, Leung J, Jowell P. Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial. Am J Gastroenterol. 2005;100:2395–2402. DOI: https://doi.org/10.1111/j.1572-0241.2005.00306.x

Laine L, Shah A. Randomized trial of urgent vs. elective colonoscopy in patients hospitalized with lower GI bleeding. Am J Gastroenterol. 2010;105:2636–2641; quiz 2642. DOI: https://doi.org/10.1038/ajg.2010.277

Kouanda AM, Somsouk M, Sewell JL, Day LW. Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis. Gastrointest Endosc. 2017;86:107–117.e1. DOI: https://doi.org/10.1016/j.gie.2017.01.035

Sengupta N, Tapper EB, Feuerstein JD. Early Versus Delayed Colonoscopy in Hospitalized Patients With Lower Gastrointestinal Bleeding: A Meta-Analysis. J Clin Gastroenterol. 2017;51:352–359. DOI: https://doi.org/10.1097/MCG.0000000000000602

Seth A, Khan MA, Nollan R, Gupta D, Kamal S, Singh U, Kamal F, Howden CW. Does Urgent Colonoscopy Improve Outcomes in the Management of Lower Gastrointestinal Bleeding? Am J Med Sci. 2017;353:298–306. DOI: https://doi.org/10.1016/j.amjms.2016.11.007

Niikura R, Nagata N, Yamada A, Doyama H, Shiratori Y, Nishida T, Kiyotoki S, Yada T, Fujita T, Sumiyoshi T, Hasatani K, Mikami T, Honda T, Mabe K, Hara K, Yamamoto K, Takeda M, Takata M, Tanaka M, Shinozaki T, Fujishiro M, Koike K. A multicenter, randomized controlled trial comparing the identification rate of stigmata of recent hemorrhage and rebleeding rate between early and elective colonoscopy in outpatient-onset acute lower gastrointestinal bleeding: study protocol for a randomized controlled trial. Trials. 2018;19:214. DOI: https://doi.org/10.1186/s13063-018-2558-y

Nagata N, Niikura R, Sakurai T, Shimbo T, Aoki T, Moriyasu S, Sekine K, Okubo H, Imbe K, Watanabe K, Yokoi C, Yanase M, Akiyama J, Uemura N. Safety and Effectiveness of Early Colonoscopy in Management of Acute Lower Gastrointestinal Bleeding on the Basis of Propensity Score Matching Analysis. Clin Gastroenterol Hepatol. 2016;14:558–564. DOI: https://doi.org/10.1016/j.cgh.2015.10.011

Strate LL, Naumann CR. The role of colonoscopy and radiological procedures in the management of acute lower intestinal bleeding. Clin Gastroenterol Hepatol. 2010;8:333–343; quiz e44. DOI: https://doi.org/10.1016/j.cgh.2009.12.017

Aoki T, Yamada A, Nagata N, Niikura R, Hirata Y, Koike K. External validation of the NOBLADS score, a risk scoring system for severe acute lower gastrointestinal bleeding. PLoS One. 2018;13:e0196514. DOI: https://doi.org/10.1371/journal.pone.0196514

Niikura R, Nagata N, Aoki T, Shimbo T, Tanaka S, Sekine K, Kishida Y, Watanabe K, Sakurai T, Yokoi C, Yanase M, Akiyama J, Mizokami M, Uemura N. Predictors for identification of stigmata of recent hemorrhage on colonic diverticula in lower gastrointestinal bleeding. J Clin Gastroenterol. 2015;49:e24–e30. DOI: https://doi.org/10.1097/MCG.0000000000000140

Ishii N, Hirata N, Omata F, Itoh T, Uemura M, Matsuda M, Suzuki S, Iizuka Y, Fukuda K, Fujita Y. Location in the ascending colon is a predictor of refractory colonic diverticular hemorrhage after endoscopic clipping. Gastrointest Endosc. 2012;76:1175–1181. DOI: https://doi.org/10.1016/j.gie.2012.07.040

García-Blázquez V, Vicente-Bártulos A, Olavarria-Delgado A, Plana MN, van der Winden D, Zamora J; EBM-Connect Collaboration. Accuracy of CT angiography in the diagnosis of acute gastrointestinal bleeding: systematic review and meta-analysis. Eur Radiol. 2013;23:1181–1190. DOI: https://doi.org/10.1007/s00330-012-2721-x

Nagata N, Niikura R, Aoki T, Moriyasu S, Sakurai T, Shimbo T, Shinozaki M, Sekine K, Okubo H, Watanabe K, Yokoi C, Yanase M, Akiyama J, Uemura N. Role of urgent contrast-enhanced multidetector computed tomography for acute lower gastrointestinal bleeding in patients undergoing early colonoscopy. J Gastroenterol. 2015;50:1162–1172. DOI: https://doi.org/10.1007/s00535-015-1069-9

Nakatsu S, Yasuda H, Maehata T, Nomoto M, Ohinata N, Hosoya K, Ishigooka S, Ozawa S, Ikeda Y, Sato Y, Suzuki M, Kiyokawa H, Yamamoto H, Itoh F. Urgent computed tomography for determining the optimal timing of colonoscopy in patients with acute lower gastrointestinal bleeding. Intern Med. 2015;54:553–558. DOI: https://doi.org/10.2169/internalmedicine.54.2829

Sugiyama T, Hirata Y, Kojima Y, Kanno T, Kimura M, Okuda Y, Haneda K, Ikeuchi H, Morikawa T, Mochizuki H, Takada H, Sobue S. Efficacy of Contrast-enhanced Computed Tomography for the Treatment Strategy of Colonic Diverticular Bleeding. Intern Med. 2015;54:2961–2967. DOI: https://doi.org/10.2169/internalmedicine.54.5097

Umezawa S, Nagata N, Arimoto J, Uchiyama S, Higurashi T, Nakano K, Ishii N, Sakurai T, Moriyasu S, Takeda Y, Nagase H, Komatsu H, Nakajima A, Mizuki A. Contrast-enhanced CT for Colonic Diverticular Bleeding before Colonoscopy: A Prospective Multicenter Study. Radiology. 2018;288:755–761. DOI: https://doi.org/10.1148/radiol.2018172910

Obana T, Fujita N, Sugita R, Hirasawa D, Sugawara T, Harada Y, Oohira T, Maeda Y, Koike Y, Suzuki K, Yamagata T, Kusaka J, Masu K. Prospective evaluation of contrast-enhanced computed tomography for the detection of colonic diverticular bleeding. Dig Dis Sci. 2013;58:1985–1990. DOI: https://doi.org/10.1007/s10620-013-2629-6

Khanna A, Ognibene SJ, Koniaris LG. Embolization as first-line therapy for diverticulosis-related massive lower gastrointestinal bleeding: evidence from a meta-analysis. J Gastrointest Surg. 2005;9:343–352. DOI: https://doi.org/10.1016/j.gassur.2004.09.039

Ali M, Ul Haq T, Salam B, Beg M, Sayani R, Azeemuddin M. Treatment of nonvariceal gastrointestinal hemorrhage by transcatheter embolization. Radiol Res Pract. 2013;2013:604328. DOI: https://doi.org/10.1155/2013/604328

Yata S, Ihaya T, Kaminou T, Hashimoto M, Ohuchi Y, Umekita Y, Ogawa T. Transcatheter arterial embolization of acute arterial bleeding in the upper and lower gastrointestinal tract with N-butyl-2-cyanoacrylate. J Vasc Interv Radiol. 2013;24:422–431. DOI: https://doi.org/10.1016/j.jvir.2012.11.024

Yi WS, Garg G, Sava JA. Localization and definitive control of lower gastrointestinal bleeding with angiography and embolization. Am Surg. 2013;79:375–380. DOI: https://doi.org/10.1177/000313481307900426

Krüger K, Heindel W, Dölken W, Landwehr P, Lackner K. Angiographic detection of gastrointestinal bleeding. An experimental comparison of conventional screen-film angiography and digital subtraction angiography. Invest Radiol. 1996;31:451–457. DOI: https://doi.org/10.1097/00004424-199607000-00008

Lee L, Iqbal S, Najmeh S, Fata P, Razek T, Khwaja K. Mesenteric angiography for acute gastrointestinal bleed: predictors of active extravasation and outcomes. Can J Surg. 2012;55:382–388. DOI: https://doi.org/10.1503/cjs.005611

Rasuli P, Doumit J, Boulos M, Rizk C, Doumit G. Factors influencing the yield of mesenteric angiography in lower gastrointestinal bleed. World J Radiol. 2014;6:218–222.] DOI: https://doi.org/10.4329/wjr.v6.i5.218

Kuhle WG, Sheiman RG. Detection of active colonic hemorrhage with use of helical CT: findings in a swine model. Radiology. 2003;228:743–752. DOI: https://doi.org/10.1148/radiol.2283020756

Czymek R, Kempf A, Roblick UJ, Bader FG, Habermann J, Kujath P, Bruch HP, Fischer F. Surgical treatment concepts for acute lower gastrointestinal bleeding. J Gastrointest Surg. 2008;12:2212–2220. DOI: https://doi.org/10.1007/s11605-008-0597-5

Farrell JJ, Friedman LS. Review article: the management of lower gastrointestinal bleeding. Aliment Pharmacol Ther. 2005;21:1281–1298. DOI: https://doi.org/10.1111/j.1365-2036.2005.02485.x

Britt LG, Warren L, Moore OF 3rd. Selective management of lower gastrointestinal bleeding. Am Surg. 1983;49:121–125.

Leitman IM, Paull DE, Shires GT 3rd. Evaluation and management of massive lower gastrointestinal hemorrhage. Ann Surg. 1989;209:175–180. DOI: https://doi.org/10.1097/00000658-198902000-00007

Parkes BM, Obeid FN, Sorensen VJ, Horst HM, Fath JJ. The management of massive lower gastrointestinal bleeding. Am Surg. 1993;59:676–678.

Farner R, Lichliter W, Kuhn J, Fisher T. Total colectomy versus limited colonic resection for acute lower gastrointestinal bleeding. Am J Surg. 1999;178:587–591. DOI: https://doi.org/10.1016/S0002-9610(99)00235-4

Matsuhashi N, Akahane M, Nakajima A. Barium impaction therapy for refractory colonic diverticular bleeding. AJR Am J Roentgenol. 2003;180:490–492. DOI: https://doi.org/10.2214/ajr.180.2.1800490

Iwamoto J, Mizokami Y, Shimokobe K, Matsuoka T, Matsuzaki Y. Therapeutic barium enema for bleeding colonic diverticula: four case series and review of the literature. World J Gastroenterol. 2008;14:6413–6417. DOI: https://doi.org/10.3748/wjg.14.6413

Pausawasdi N, Al-Hawary M, Higgins PD. Therapeutic high-density barium enema in a case of presumed diverticular hemorrhage. Case Rep Gastroenterol. 2011;5:88–94. DOI: https://doi.org/10.1159/000322911

Niikura R, Nagata N, Yamano K, Shimbo T, Uemura N. High-dose barium impaction therapy is useful for the initial hemostasis and for preventing the recurrence of colonic diverticular bleeding unresponsive to endoscopic clipping. Case Rep Gastrointest Med. 2013;2013:365954. DOI: https://doi.org/10.1155/2013/365954

Koga M, Kusano C, Gotoda T, Suzuki S, Sato T, Fukuzawa M, Itoi T, Moriyasu F. Barium impaction therapy with balloon occlusion for deep colonic diverticular bleeding: a three-case series. Endosc Int Open. 2016;4:E560–E563. DOI: https://doi.org/10.1055/s-0042-103237

Nagata N, Niikura R, Shimbo T, Ishizuka N, Yamano K, Mizuguchi K, Akiyama J, Yanase M, Mizokami M, Uemura N. High-dose barium impaction therapy for the recurrence of colonic diverticular bleeding: a randomized controlled trial. Ann Surg. 2015;261:269–275. DOI: https://doi.org/10.1097/SLA.0000000000000658

Yamada A, Sugimoto T, Kondo S, Ohta M, Watabe H, Maeda S, Togo G, Yamaji Y, Ogura K, Okamoto M, Yoshida H, Kawabe T, Kawase T, Omata M. Assessment of the risk factors for colonic diverticular hemorrhage. Dis Colon Rectum. 2008;51:116–120. DOI: https://doi.org/10.1007/s10350-007-9137-8

Nagata N, Niikura R, Aoki T, Shimbo T, Kishida Y, Sekine K, Tanaka S, Okubo H, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N. Lower GI bleeding risk of nonsteroidal anti-inflammatory drugs and antiplatelet drug use alone and the effect of combined therapy. Gastrointest Endosc. 2014;80:1124–1131. DOI: https://doi.org/10.1016/j.gie.2014.06.039

Lanas Á, Carrera-Lasfuentes P, Arguedas Y, García S, Bujanda L, Calvet X, Ponce J, Perez-Aísa Á, Castro M, Muñoz M, Sostres C, García-Rodríguez LA. Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants. Clin Gastroenterol Hepatol. 2015;13:906–912.e2 DOI: https://doi.org/10.1016/j.cgh.2014.11.007

Nagata N, Niikura R, Aoki T, Shimbo T, Sekine K, Okubo H, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N. Impact of discontinuing non-steroidal antiinflammatory drugs on long-term recurrence in colonic diverticular bleeding. World J Gastroenterol. 2015;21:1292–1298. DOI: https://doi.org/10.3748/wjg.v21.i4.1292

Laine L, Curtis SP, Langman M, Jensen DM, Cryer B, Kaur A, Cannon CP. Lower gastrointestinal events in a double-blind trial of the cyclo-oxygenase-2 selective inhibitor etoricoxib and the traditional nonsteroidal anti-inflammatory drug diclofenac. Gastroenterology. 2008;135:1517–1525. DOI: https://doi.org/10.1053/j.gastro.2008.07.067

Oakland K, Desborough MJ, Murphy MF, Schachter M, Jairath V. Re-bleeding and Mortality After Lower Gastrointestinal Bleeding in Patients Taking Anti-platelets or Anti-coagulants. Clin Gastroenterol Hepatol. 2017

Casado Arroyo R, Polo-Tomas M, Roncalés MP, Scheiman J, Lanas A. Lower GI bleeding is more common than upper among patients on dual antiplatelet therapy: long-term follow-up of a cohort of patients commonly using PPI co-therapy. Heart. 2012;98:718–723. DOI: https://doi.org/10.1136/heartjnl-2012-301632

Abraham NS, Hartman C, Richardson P, Castillo D, Street RL Jr, Naik AD. Risk of lower and upper gastrointestinal bleeding, transfusions, and hospitalizations with complex antithrombotic therapy in elderly patients. Circulation. 2013;128:1869–1877. DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.004747

Chan FK, Leung Ki EL, Wong GL, Ching JY, Tse YK, Au KW, Wu JC, Ng SC. Risks of Bleeding Recurrence and Cardiovascular Events With Continued Aspirin Use After Lower Gastrointestinal Hemorrhage. Gastroenterology. 2016;151:271–277. DOI: https://doi.org/10.1053/j.gastro.2016.04.013

Sung JJ, Lau JY, Ching JY, Wu JC, Lee YT, Chiu PW, Leung VK, Wong VW, Chan FK. Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial. Ann Intern Med. 2010;152:1–9. DOI: https://doi.org/10.7326/0003-4819-152-1-201001050-00179

Antithrombotic Trialists' (ATT) Collaboration. Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, Peto R, Buring J, Hennekens C, Kearney P, Meade T, Patrono C, Roncaglioni MC, Zanchetti A. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009;373:1849–1860. DOI: https://doi.org/10.1016/S0140-6736(09)60503-1

Ho PM, Peterson ED, Wang L, Magid DJ, Fihn SD, Larsen GC, Jesse RA, Rumsfeld JS. Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. JAMA. 2008;299:532–539. DOI: https://doi.org/10.1001/jama.299.5.532

Eisenberg MJ, Richard PR, Libersan D, Filion KB. Safety of short-term discontinuation of antiplatelet therapy in patients with drug-eluting stents. Circulation. 2009;119:1634–1642. DOI: https://doi.org/10.1161/CIRCULATIONAHA.108.813667

Choudari CP, Rajgopal C, Palmer KR. Acute gastrointestinal haemorrhage in anticoagulated patients: diagnoses and response to endoscopic treatment. Gut. 1994;35:464–466. DOI: https://doi.org/10.1136/gut.35.4.464

Wolf AT, Wasan SK, Saltzman JR. Impact of anticoagulation on rebleeding following endoscopic therapy for nonvariceal upper gastrointestinal hemorrhage. Am J Gastroenterol. 2007;102:290–296. DOI: https://doi.org/10.1111/j.1572-0241.2006.00969.x

Shingina A, Barkun AN, Razzaghi A, Martel M, Bardou M, Gralnek I; RUGBE Investigators. Systematic review: the presenting international normalised ratio (INR) as a predictor of outcome in patients with upper nonvariceal gastrointestinal bleeding. Aliment Pharmacol Ther. 2011;33:1010–1018. DOI: https://doi.org/10.1111/j.1365-2036.2011.04618.x

Nagata N, Sakurai T, Moriyasu S, Shimbo T, Okubo H, Watanabe K, Yokoi C, Yanase M, Akiyama J, Uemura N. Impact of INR monitoring, reversal agent use, heparin bridging, and anticoagulant interruption on rebleeding and thromboembolism in acute gastrointestinal bleeding. PLoS One. 2017;12:e0183423. DOI: https://doi.org/10.1371/journal.pone.0183423

Rubin TA, Murdoch M, Nelson DB. Acute GI bleeding in the setting of supratherapeutic international normalized ratio in patients taking warfarin: endoscopic diagnosis, clinical management, and outcomes. Gastrointest Endosc. 2003;58:369–373. DOI: https://doi.org/10.1067/S0016-5107(03)00010-5

Jairath V, Kahan BC, Stanworth SJ, Logan RF, Hearnshaw SA, Travis SP, Palmer KR, Murphy MF. Prevalence, management, and outcomes of patients with coagulopathy after acute nonvariceal upper gastrointestinal bleeding in the United Kingdom. Transfusion. 2013;53:1069–1076. DOI: https://doi.org/10.1111/j.1537-2995.2012.03849.x

Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, O’Gara PT, Ruiz CE, Skubas NJ, Sorajja P, Sundt TM 3rd, Thomas JD; ACC/AHA Task Force Members. 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129:e521–e643. DOI: https://doi.org/10.1161/CIR.0000000000000031

Holbrook A, Schulman S, Witt DM, Vandvik PO, Fish J, Kovacs MJ, Svensson PJ, Veenstra DL, Crowther M, Guyatt GH. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e152S–e184S. DOI: https://doi.org/10.1378/chest.11-2295

van Ryn J, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, Clemens A. Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost. 2010;103:1116–1127. DOI: https://doi.org/10.1160/TH09-11-0758

Khadzhynov D, Wagner F, Formella S, Wiegert E, Moschetti V, Slowinski T, Neumayer HH, Liesenfeld KH, Lehr T, Härtter S, Friedman J, Peters H, Clemens A. Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease. Thromb Haemost. 2013;109:596–605. DOI: https://doi.org/10.1160/TH12-08-0573

Pollack CV Jr, Reilly PA, Eikelboom J, Glund S, Verhamme P, Bernstein RA, Dubiel R, Huisman MV, Hylek EM, Kamphuisen PW, Kreuzer J, Levy JH, Sellke FW, Stangier J, Steiner T, Wang B, Kam CW, Weitz JI. Idarucizumab for Dabigatran Reversal. N Engl J Med. 2015;373:511–520. DOI: https://doi.org/10.1056/NEJMoa1502000

Weitz JI, Pollack CV Jr. Practical management of bleeding in patients receiving non-vitamin K antagonist oral anticoagulants. Thromb Haemost. 2015;114:1113–1126. DOI: https://doi.org/10.1160/TH15-03-0222

Douketis JD, Spyropoulos AC, Kaatz S, Becker RC, Caprini JA, Dunn AS, Garcia DA, Jacobson A, Jaffer AK, Kong DF, Schulman S, Turpie AG, Hasselblad V, Ortel TL; BRIDGE Investigators. Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation. N Engl J Med. 2015;373:823–833. DOI: https://doi.org/10.1056/NEJMoa1501035

Beyer-Westendorf J, Gelbricht V, Förster K, Ebertz F, Köhler C, Werth S, Kuhlisch E, Stange T, Thieme C, Daschkow K, Weiss N. Peri-interventional management of novel oral anticoagulants in daily care: results from the prospective Dresden NOAC registry. Eur Heart J. 2014;35:1888–1896. DOI: https://doi.org/10.1093/eurheartj/eht557

Chai-Adisaksopha C, Hillis C, Monreal M, Witt DM, Crowther M. Thromboembolic events, recurrent bleeding and mortality after resuming anticoagulant following gastrointestinal bleeding. A meta-analysis. Thromb Haemost. 2015;114:819–825. DOI: https://doi.org/10.1160/TH15-01-0063

Witt DM, Delate T, Garcia DA, Clark NP, Hylek EM, Ageno W, Dentali F, Crowther MA. Risk of thromboembolism, recurrent hemorrhage, and death after warfarin therapy interruption for gastrointestinal tract bleeding. Arch Intern Med. 2012;172:1484–1491. DOI: https://doi.org/10.1001/archinternmed.2012.4261

Qureshi W, Mittal C, Patsias I, Garikapati K, Kuchipudi A, Cheema G, Elbatta M, Alirhayim Z, Khalid F. Restarting anticoagulation and outcomes after major gastrointestinal bleeding in atrial fibrillation. Am J Cardiol. 2014;113:662–668. DOI: https://doi.org/10.1016/j.amjcard.2013.10.044

Sengupta N, Feuerstein JD, Patwardhan VR, Tapper EB, Ketwaroo GA, Thaker AM, Leffler DA. The risks of thromboembolism vs. recurrent gastrointestinal bleeding after interruption of systemic anticoagulation in hospitalized inpatients with gastrointestinal bleeding: a prospective study. Am J Gastroenterol. 2015;110:328–335. DOI: https://doi.org/10.1038/ajg.2014.398

Sherwood MW, Douketis JD, Patel MR, Piccini JP, Hellkamp AS, Lokhnygina Y, Spyropoulos AC, Hankey GJ, Singer DE, Nessel CC, Mahaffey KW, Fox KA, Califf RM, Becker RC; ROCKET AF Investigators. Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF) Circulation. 2014;129:1850–1859. DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.005754

Sengupta N, Marshall AL, Jones BA, Ham S, Tapper EB. Rebleeding vs Thromboembolism After Hospitalization for Gastrointestinal Bleeding in Patients on Direct Oral Anticoagulants. Clin Gastroenterol Hepatol. 2018;16:1893–1900.e2. DOI: https://doi.org/10.1016/j.cgh.2018.05.005

Desai J, Kolb JM, Weitz JI, Aisenberg J. Gastrointestinal bleeding with the new oral anticoagulants--defining the issues and the management strategies. Thromb Haemost. 2013;110:205–212. DOI: https://doi.org/10.1160/TH13-02-0150

Lip GYH, Lane DA. Matching the NOAC to the Patient: Remember the Modifiable Bleeding Risk Factors. J Am Coll Cardiol. 2015;66:2282–2284. DOI: https://doi.org/10.1016/j.jacc.2015.07.086

Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, Camm AJ, Weitz JI, Lewis BS, Parkhomenko A, Yamashita T, Antman EM. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383:955–962. DOI: https://doi.org/10.1016/S0140-6736(13)62343-0

Abraham NS, Noseworthy PA, Yao X, Sangaralingham LR, Shah ND. Gastrointestinal Safety of Direct Oral Anticoagulants: A Large Population-Based Study. Gastroenterology. 2017;152:1014–1022.e1. DOI: https://doi.org/10.1053/j.gastro.2016.12.018

Noseworthy PA, Yao X, Abraham NS, Sangaralingham LR, McBane RD, Shah ND. Direct Comparison of Dabigatran, Rivaroxaban, and Apixaban for Effectiveness and Safety in Nonvalvular Atrial Fibrillation. Chest. 2016;150:1302–1312. DOI: https://doi.org/10.1016/j.chest.2016.07.013

Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest. 2010;138:1093–1100. DOI: https://doi.org/10.1378/chest.10-0134

Shimomura A, Nagata N, Shimbo T, Sakurai T, Moriyasu S, Okubo H, Watanabe K, Yokoi C, Akiyama J, Uemura N. New predictive model for acute gastrointestinal bleeding in patients taking oral anticoagulants: A cohort study. J Gastroenterol Hepatol. 2018;33:164–171. DOI: https://doi.org/10.1111/jgh.13830

Wada M, Kato M, Hirai Y, Kubosawa Y, Sunata Y, Abe K, Hirata T, Takada Y, Banno S, Takatori Y, Kinoshita S, Mori H, Takabayashi K, Kikuchi M, Kikuchi M, Suzuki M, Kanai T, Uraoka T. Initial Management of Colonic Diverticular Bleeding: Observational Study. Digestion. 2018;98:41–47. DOI: https://doi.org/10.1159/000487264

Aoki, T., Hirata, Y., Yamada, A., & Koike, K. (2019). Initial management for acute lower gastrointestinal bleeding. World journal of gastroenterology, 25(1), 69–84. https://doi.org/10.3748/wjg.v25.i1.69 DOI: https://doi.org/10.3748/wjg.v25.i1.69

Published

15-01-2019

How to Cite

Alanazi, S. M., Alotaibi, H. F., Alanazi, I. M., Aldukhain, A. M., Alharbi, S. A., Alanizi, H. G., Alsari, F. A. H., Alghufaili, R. S. A., & Almansour, S. A. (2019). Addressing acute gastrointestinal emergencies: From hemorrhage to obstruction. International Journal of Health Sciences, 3(S1), 229–252. https://doi.org/10.53730/ijhs.v3nS1.15137

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