Emergency of outpatient anaphylactic shock

Review article

https://doi.org/10.53730/ijhs.v1nS1.15156

Authors

  • Hatim Faihan Alotaibi KSA, National Guard Health Affairs
  • Ibrahim Mohammed Alanazi KSA, National Guard Health Affairs
  • Adel Mohammad Aldukhain KSA, National Guard Health Affairs
  • Rakan Faisal Albasri KSA, National Guard Health Affairs
  • Hamoud Ghayyadh Alanizi KSA, National Guard Health Affairs
  • Ahmed Hasaan Alshammari KSA, National Guard Health Affairs
  • Saif Helal Almutairi KSA, National Guard Health Affairs

Keywords:

anaphylaxis, outpatient emergency, epinephrine, airway management, immunoglobulin E, allergic reaction, shock, emergency preparedness

Abstract

Background: Anaphylaxis is a severe, potentially life-threatening allergic reaction triggered by substances such as food, medications, insect stings, or environmental factors. It presents a range of symptoms, including respiratory, cardiovascular, dermatological, and gastrointestinal manifestations, which can develop rapidly. Misdiagnosis is common, as symptoms overlap with conditions such as septic shock or asthma. The immediate administration of intramuscular epinephrine is critical for treatment, along with airway management, antihistamines, and glucocorticoids. Aim: This review aims to explore the outpatient management of anaphylactic shock, focusing on symptoms, treatment strategies, and emergency preparedness. The review emphasizes the importance of rapid intervention and staff training for successful management. Methods: Methods involve analyzing current literature on anaphylaxis, its clinical presentation, and emergency treatment protocols. Results: Results show that early epinephrine administration is crucial for improving outcomes, with delayed treatment contributing to increased fatality risks. Regular preparedness, such as maintaining an anaphylaxis cart and conducting staff drills, is vital for effective outpatient care. Conclusion: The conclusion underscores the necessity of equipping outpatient settings with proper protocols and emergency supplies to manage anaphylactic emergencies and the need for patient education on recognizing and managing future episodes.

Downloads

Download data is not yet available.

References

Neugut AI, Ghatak AT, Miller RL. Anaphylaxis in the United States: an investiga tion into its epidemiology. Arch Intern Med 2001;161(1):15–21. DOI: https://doi.org/10.1001/archinte.161.1.15

Wood RA, Camargo CA Jr, Lieberman P, et al. Anaphylaxis in America: the prev alence and characteristics of anaphylaxis in the United States. J Allergy Clin Im munol 2014;133(2):461–7. DOI: https://doi.org/10.1016/j.jaci.2013.08.016

Brown SG, Stone SF, Fatovich DM, et al. Anaphylaxis: clinical patterns, mediator release, and severity. J Allergy Clin Immunol 2013;132(5):1141–9.e5. DOI: https://doi.org/10.1016/j.jaci.2013.06.015

Lieberman P, Nicklas RA, Randolph C, et al. Anaphylaxis–a practice parameter update 2015. Ann Allergy Asthma Immunol 2015;115(5):341–84. DOI: https://doi.org/10.1016/j.anai.2015.07.019

Sampson HA, Munoz-Furlong A, Campbell RL, et al. Second symposium on the definition and management of anaphylaxis: summary report–second National 14 Commins Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. Ann Emerg Med 2006;47(4):373–80. DOI: https://doi.org/10.1016/j.annemergmed.2006.01.018

Schwartz LB, Metcalfe DD, Miller JS, et al. Tryptase levels as an indicator of mast cell activation in systemic anaphylaxis and mastocytosis. N Engl J Med 1987; 316(26):1622–6. DOI: https://doi.org/10.1056/NEJM198706253162603

Vadas P, Gold M, Perelman B, et al. Platelet-activating factor, PAF acetylhydro lase, and severe anaphylaxis. N Engl J Med 2008;358(1):28–35. DOI: https://doi.org/10.1056/NEJMoa070030

Ellis AK, Day JH. The role of epinephrine in the treatment of anaphylaxis. Curr Al lergy Asthma Rep 2003;3(1):11–4. DOI: https://doi.org/10.1007/s11882-003-0004-y

Ellis AK. Priority role of epinephrine in anaphylaxis further underscored–the impact on biphasic anaphylaxis. Ann Allergy Asthma Immunol 2015;115(3):165. DOI: https://doi.org/10.1016/j.anai.2015.06.024

Ellis AK, Day JH. Incidence and characteristics of biphasic anaphylaxis: a pro spective evaluation of 103 patients. Ann Allergy Asthma Immunol 2007;98(1): 64–9. DOI: https://doi.org/10.1016/S1081-1206(10)60861-7

Altman AM, Camargo CA, Simons FE, et al. Anaphylaxis in America: a national physician survey. J Allergy Clin Immunol 2015;135(3):830–3. DOI: https://doi.org/10.1016/j.jaci.2014.10.049

Lieberman P, Nicklas RA, Oppenheimer J, et al. The diagnosis and management of anaphylaxis practice parameter: 2010 update. J Allergy Clin Immunol 2010; 126(3):477–80.e1-42. DOI: https://doi.org/10.1016/j.jaci.2010.06.022

Viner NA, Rhamy RK. Anaphylaxis manifested by hypotension alone. J Urol 1975; 113(1):108–10. DOI: https://doi.org/10.1016/S0022-5347(17)59419-7

Sampson HA, Munoz-Furlong A, Bock SA, et al. Symposium on the definition and management of anaphylaxis: summary report. J Allergy Clin Immunol 2005; 115(3):584–91. DOI: https://doi.org/10.1016/j.jaci.2005.01.009

Valabhji J, Robinson S, Johnston D, et al. Unexplained loss of consciousness: systemic mastocytosis. J R Soc Med 2000;93(3):141–2. DOI: https://doi.org/10.1177/014107680009300309

Commins SP, Satinover SM, Hosen J, et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J Allergy Clin Immunol 2009;123(2):426–33. DOI: https://doi.org/10.1016/j.jaci.2008.10.052

Chung CH, Mirakhur B, Chan E, et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N Engl J Med 2008;358(11):1109–17. DOI: https://doi.org/10.1056/NEJMoa074943

Commins SP, James HR, Kelly LA, et al. The relevance of tick bites to the produc tion of IgE antibodies to the mammalian oligosaccharide galactose-a-1,3-galac tose. J Allergy Clin Immunol 2011;127(5):1286–93.e6. DOI: https://doi.org/10.1016/j.jaci.2011.02.019

Campbell RL, Li JT, Nicklas RA, et al, Members of the Joint Task Force, Practice Parameter Workgroup. Emergency department diagnosis and treatment of anaphylaxis: a practice parameter. Ann Allergy Asthma Immunol 2014;113(6): 599–608. DOI: https://doi.org/10.1016/j.anai.2014.10.007

Ellis AK, Day JH. Diagnosis and management of anaphylaxis. CMAJ 2003;169(4): 307–11.

Toogood JH. Risk of anaphylaxis in patients receiving beta-blocker drugs. J Allergy Clin Immunol 1988;81(1):1–5. DOI: https://doi.org/10.1016/0091-6749(88)90212-6

Berg RA, Hemphill R, Abella BS, et al. Part 5: adult basic life support: 2010 Amer ican Heart association guidelines for cardiopulmonary resuscitation and emer gency cardiovascular care. Circulation 2010;122(18 Suppl 3):S685–705. DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.970939

Commins SP, Platts-Mills TA. Allergenicity of carbohydrates and their role in anaphylactic events. Curr Allergy Asthma Rep 2010;10(1):29–33. DOI: https://doi.org/10.1007/s11882-009-0079-1

Kaliner M, Shelhamer JH, Ottesen EA. Effects of infused histamine: correlation of plasma histamine levels and symptoms. J Allergy Clin Immunol 1982;69(3): 283–9. 15 Outpatient Emergencies DOI: https://doi.org/10.1016/S0091-6749(82)80005-5

Maier S, Chung CH, Morse M, et al. A retrospective analysis of cross-reacting ce tuximab IgE antibody and its association with severe infusion reactions. Cancer Med 2014;4(1):36–42. DOI: https://doi.org/10.1002/cam4.333

Pointreau Y, Commins SP, Calais G, et al. Fatal infusion reactions to cetuximab: role of immunoglobulin e-mediated anaphylaxis. J Clin Oncol 2012;30(3):334 [author reply: 335]. DOI: https://doi.org/10.1200/JCO.2011.38.4701

Simon RA, Schatz M, Stevenson DD, et al. Radiographic contrast media infu sions. Measurement of histamine, complement, and fibrin split products and cor relation with clinical parameters. J Allergy Clin Immunol 1979;63(4):281–8. DOI: https://doi.org/10.1016/0091-6749(79)90114-3

Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphy lactic reactions to food, 2001-2006. J Allergy Clin Immunol 2007;119(4):1016–8. DOI: https://doi.org/10.1016/j.jaci.2006.12.622

Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reac tions to foods. J Allergy Clin Immunol 2001;107(1):191–3. DOI: https://doi.org/10.1067/mai.2001.112031

Neumar RW, Otto CW, Link MS, et al. Part 8: adult advanced cardiovascular life support: 2010 American Heart Association guidelines for cardiopulmonary resus citation and emergency cardiovascular care. Circulation 2010;122(18 Suppl 3): S729–67. DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.970988

Beavers CJ, Pandya KA. Pharmacotherapy considerations for the management of advanced cardiac life support. Nurs Clin North Am 2016;51(1):69–82. DOI: https://doi.org/10.1016/j.cnur.2015.10.003

Hannibal GB. 2015 advanced cardiac life support updates and strategies for improving survival after cardiac arrest. AACN Adv Crit Care 2016;27(2):241–7. DOI: https://doi.org/10.4037/aacnacc2016955

Orban JC, Giolito D, Tosi J, et al. Factors associated with initiation of medical advanced cardiac life support after out-of-hospital cardiac arrest. Ann Intensive Care 2016;6(1):12. DOI: https://doi.org/10.1186/s13613-016-0115-y

Rank MA, Oslie CL, Krogman JL, et al. Allergen immunotherapy safety: charac terizing systemic reactions and identifying risk factors. Allergy Asthma Proc 2008;29(4):400–5. DOI: https://doi.org/10.2500/aap.2008.29.3141

Simons FE, Gu X, Simons KJ. Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol 2001;108(5):871–3. DOI: https://doi.org/10.1067/mai.2001.119409

Simons FE, Roberts JR, Gu X, et al. Epinephrine absorption in children with a his tory of anaphylaxis. J Allergy Clin Immunol 1998;101(1 Pt 1):33–7. DOI: https://doi.org/10.1016/S0091-6749(98)70190-3

Manivannan V, Campbell RL, Bellolio MF, et al. Factors associated with repeated use of epinephrine for the treatment of anaphylaxis. Ann Allergy Asthma Immunol 2009;103(5):395–400. DOI: https://doi.org/10.1016/S1081-1206(10)60358-4

Oren E, Banerji A, Clark S, et al. Food-induced anaphylaxis and repeated epinephrine treatments. Ann Allergy Asthma Immunol 2007;99(5):429–32. DOI: https://doi.org/10.1016/S1081-1206(10)60568-6

SampsonHA,MendelsonL,RosenJP.Fatal andnear-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med 1992;327(6):380–4. DOI: https://doi.org/10.1056/NEJM199208063270603

Simons FE, Frew AJ, Ansotegui IJ, et al. Practical allergy (PRACTALL) report: risk assessment in anaphylaxis. Allergy 2008;63(1):35–7. DOI: https://doi.org/10.1111/j.1398-9995.2007.01605.x

Ali J, Adam RU, Gana TJ, et al. Trauma patient outcome after the Prehospital Trauma Life Support program. J Trauma 1997;42(6):1018–21 [discussion: 1021–2]. DOI: https://doi.org/10.1097/00005373-199706000-00005

Wolfl CG, Bouillon B, Lackner CK, et al. Prehospital Trauma Life Support (PHTLS): an interdisciplinary training in preclinical trauma care. Unfallchirurg 2008;111(9): 688–94 [in German]. DOI: https://doi.org/10.1007/s00113-008-1466-0

Peberdy MA, Callaway CW, Neumar RW, et al. Part 9: post-cardiac arrest care: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010;122(18 Suppl 3):S768–86. DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.971002

Pumphrey RS. Fatal posture in anaphylactic shock. J Allergy Clin Immunol 2003; 112(2):451–2. 16 Commins DOI: https://doi.org/10.1067/mai.2003.1614

Berg MD, Schexnayder SM, Chameides L, et al. Part 13: pediatric basic life sup port: 2010 American Heart Association guidelines for cardiopulmonary resuscita tion and emergency cardiovascular care. Circulation 2010;122(18 Suppl 3): S862–75. DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.971085

Brown SG, Blackman KE, Stenlake V, et al. Insect sting anaphylaxis; prospective evaluation of treatment with intravenous adrenaline and volume resuscitation. Emerg Med J 2004;21(2):149–54. DOI: https://doi.org/10.1136/emj.2003.009449

Toogood JH. Beta-blocker therapy and the risk of anaphylaxis. CMAJ 1987; 137(7):587–8, 590–1.

Vander Zanden JA, Valuck RJ, Bunch CL, et al. Systemic adverse effects of ophthalmic beta-blockers. Ann Pharmacother 2001;35(12):1633–7. DOI: https://doi.org/10.1345/aph.18464

Matasar MJ, Neugut AI. Epidemiology of anaphylaxis in the United States. Curr Allergy Asthma Rep 2003;3(1):30–5. DOI: https://doi.org/10.1007/s11882-003-0007-8

Mulla ZD, Lin RY, Simon MR. Perspectives on anaphylaxis epidemiology in the United States with new data and analyses. Curr Allergy Asthma Rep 2011; 11(1):37–44. DOI: https://doi.org/10.1007/s11882-010-0154-7

Commins SP, James HR, Stevens W, et al. Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose. J Allergy Clin Immunol 2014;134(1):108–15. DOI: https://doi.org/10.1016/j.jaci.2014.01.024

Sicherer SH, Sampson HA. Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 2014;133(2):291–307 [quiz: 308]. DOI: https://doi.org/10.1016/j.jaci.2013.11.020

Atkins D, Bock SA. Fatal anaphylaxis to foods: epidemiology, recognition, and prevention. Curr Allergy Asthma Rep 2009;9(3):179–85. DOI: https://doi.org/10.1007/s11882-009-0027-0

Yu JE, Lin RY. The epidemiology of anaphylaxis. Clin Rev Allergy Immunol 2015. DOI: https://doi.org/10.1007/s12016-015-8503-x

Boyce JA, Assa’ad A, Burks AW, et al. Guidelines for the diagnosis and manage ment of food allergy in the United States: summary of the NIAID-sponsored expert panel report. Nutr Res 2011;31(1):61–75. DOI: https://doi.org/10.1016/j.jada.2010.10.033

Simons FE, Frew AJ, Ansotegui IJ, et al. Risk assessment in anaphylaxis: current and future approaches. J Allergy Clin Immunol 2007;120(1 Suppl):S2–24 DOI: https://doi.org/10.1016/j.jaci.2007.05.001

Published

15-01-2017

How to Cite

Alotaibi, H. F., Alanazi, I. M., Aldukhain, A. M., Albasri, R. F., Alanizi, H. G., Alshammari, A. H., & Almutairi, S. H. (2017). Emergency of outpatient anaphylactic shock: Review article. International Journal of Health Sciences, 1(S1), 62–75. https://doi.org/10.53730/ijhs.v1nS1.15156

Issue

Section

Peer Review Articles

Most read articles by the same author(s)

1 2 > >>