Effect of Ivermectin mass drug administration on the COVID-19 Pandemic
Ecological study with special reference to the State of Uttarakhand, India
Keywords:
COVID-19, Ivermectin, mass drug administrationAbstract
Uttarakhand, a hilly state of India adopted the strategy of mass drug administration of ivermectin during the second wave of COVID-19 pandemic as a measure to control the peak due to failing health infrastructure and health facility with sudden cases surge. This study was hereby planned with an aim of analyzing the effect of mass drug administration of ivermectin on the COVID-19 pandemic progression in the State of Uttarakhand. The trend of pandemic progression in five states of India was studied taking case growth rate, active case rate and case fatality rate as indicators. The percentage change in the indicators with the progression of pandemic was calculated for all five states and compared. The projected increased number of deaths, the state of Uttarakhand would have experienced, if the state had the declining average case growth of the other states taken for study was also calculated. The data analysis shows that the Uttarakhand had a sharp fall in the active cases by 3 to 4 weeks post lockdown, the period corresponding with maximum coverage of ivermectin distribution in the state.
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Arevalo, A. P., Pagotto, R., Pórfido, J. L., Daghero, H., Segovia, M., Yamasaki, K., ... & Crispo, M. (2021). Ivermectin reduces in vivo coronavirus infection in a mouse experimental model. Scientific Reports, 11(1), 1-12.
Caly, L., Druce, J. D., Catton, M. G., Jans, D. A., & Wagstaff, K. M. (2020). The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral research, 178, 104787. https://doi.org/10.1016/j.antiviral.2020.104787
Chaccour, C., Casellas, A., Blanco-Di Matteo, A., Pineda, I., Fernandez-Montero, A., Ruiz-Castillo, P., ... & Fernández-Alonso, M. (2021). The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial. EClinicalMedicine, 32, 100720. https://doi.org/10.1016/j.eclinm.2020.100720
Hellwig, M. D., & Maia, A. (2021). A COVID-19 prophylaxis? Lower incidence associated with prophylactic administration of ivermectin. International journal of antimicrobial agents, 57(1), 106248. https://doi.org/10.1016/j.ijantimicag.2020.106248
Meo, S. A., Abukhalaf, A. A., Alomar, A. A., AlMutairi, F. J., Usmani, A. M., & Klonoff, D. C. (2020). Impact of lockdown on COVID-19 prevalence and mortality during 2020 pandemic: observational analysis of 27 countries. European journal of medical research, 25(1), 1-7.
Verity, R., Okell, L. C., Dorigatti, I., Winskill, P., Whittaker, C., Imai, N., ... & Ferguson, N. M. (2020). Estimates of the severity of coronavirus disease 2019: a model-based analysis. The Lancet infectious diseases, 20(6), 669-677.
Zaidi, A. K., & Dehgani-Mobaraki, P. (2021). The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review. The Journal of antibiotics, 1-12.
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