Formulation and evaluation of gastroretentive drug delivery system of eprosartanmesylate
Keywords:
Eprosartan mesylate HPMC K100M, HPMC15M, In-vitro buoyancy studies, In-vitro drug releaseAbstract
It had became a challenging experience and effort for a formulator to develop and innovate a drug with maximum bioavailability. Objective: In the present study the focus of research is in the treatment of Hypertension, which is one of the most prevalent cardiovascular diseases in the world, affecting a big proportion of the adult and old age population. Eprosartan mesylate(EPM) is angiotensin-II receptor antagonist used for the treatment of high blood pressure. The drug has poor bioavailability due to limited oral absorption and maximum absorption at proximal intestine. This warrants and offers the use of Gastro Retentive Drug Delivery System (GRDDS) for sustained release formulation in order to achieve prolonged action and to improve patients compliance. Method: Wet granulation technique was selected for preparation of tablets and the drug is formulated with hydroxyl propyl methyl cellulose K100m, hydroxyl propyl methyl cellulose K15m, polyox WSR coagulant, polyox WSR301,polyox WSR N80, Lactose Monohydrate, Micro crystalline cellulose(Avicel), magnesium sterate, ethylcellulose, sodium bicarbonate, tromethamine, etc. Results: For around twenty formulations were made and evaluated for General appearance, Thickness, Hardness or Crushing strength Test, Friability Test, Estimation of drug content.
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References
Talukdar R, Fassihi R, Gastroretentive delivery systems: hollow beads, Drug Dev. Ind. Pharm 2004;30:405-12.
Whiteland L, Fell J.T, Collett J.H, Development of gastroretentive dosage form .Eur J Pharm Sci 1996;4:S182.
Garg R, Gupta G, Progress in controlled gastroretentive delivery systems, Trop J Pharm Res 2008;7(3):1055-66.
Gupta P.K, and Robinson J.R, Oral Controlled- Release Delivery, in Treatise on Controlled Drug Delivery, A. Kydonieus, Eds., Marcel Dekker, New Jersey 1992: 255-310.
Park K, and Robinson J.R, Bioadhesive Polymers as Platforms for Oral- Controlled Drug Delivery: Method to Study Bioadhesion, Int J Pharm1984;19(1):107-127.
Chawla G, Gupta P, Koradia V, Bansal A. Gastroretention a Means to Address Regional Variability in Intestinal Drug Absorption. Pharm Tech 2003: 50-68.
Tao S, and Desai T. Gastrointestinal patch systems for oral drug delivery DDT 2005;10:909-915.
S. Jeganath, K. Mohammed Shafiq, P.G. Mahesh, S. Sathesh Kumar, 2018. Formulation and Evaluation of non- effervescent tablests of linagliptin using low-density carriers. Drug Invention Today. 10 (3).
Surana A. and Kotecha R. An overview on various approaches to oral controlled drug delivery system via gastroretention. IJPSRR 2010;2(2):68-72.
Sheu M, Chen R, Ho.Hsiu, Yu C, Development of swelling/floating gastroretentive drug delivery system based on a combination of hydroxyethyl cellulose and sodium carboxymethyl cellulose for Losartan and its clinical relevance in healthy volunteers with CYP2C9 polymorphism. European J of Pharm Sci 2010;39: 82–89.
K Vinod, Vasa Santhosh, S Anbuazaghan, Banji David, A Padmasri, S Sandhya, Approaches for gastrotentive drug delivery systems Int J of App Bio and Pharmaceutical Tech 2010;1: 589-601.
Vibin Bose R, Jeganath S, Ramya Sree K, Sherni Prithiba Jhansi Rani S. Design and Development of Gastro retentive drug Delivery System of Ciprofloxacin Hydrochloride. Asian J Pharm Clin Res 2018; 11(4):141-146.
Johnson, R.H, Rowe E.L, Medicinal dosage forms of unpolymerised thiolated gelatin with a cross linking accelerating agent providing a slowly released medication from a swollen matrix’, U.S.Patient 1971;3: 574- 820.
Mamjek, R.C, Moyer, E.S, Drug Dispensing Device and Method, U.S Patient 1980;4: 207- 890.
J.Urquhart, F.Theeuwes, Drug delivery systems containing a plurality of tiny pils, U.S.Patient 1984;4:153.
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