Comparison of haemodynamic response to induction with propofol versus etomidate in patients scheduled for elective surgery

https://doi.org/10.53730/ijhs.v6nS2.5714

Authors

  • Jigisha B Mehta Assistant Professor, Department of Anaesthesiology, Smt. B. K. Shah Medical Institute and Research Center, Sumandeep Vidyapeeth (An Institute Deemed to be University), Piparia, Vadodara, Gujarat, India
  • Tejash H Sharma Associate Professor, Department of Anaesthesiology, Smt. B. K. Shah Medical Institute and Research Center, Sumandeep Vidyapeeth (An Institute Deemed to be University), Piparia, Vadodara, Gujarat, India
  • Venkata Suryanarayana Gopavajhula 3rd year resident, Department of Anaesthesiology, Smt. B. K. Shah Medical Institute and Research Center, Sumandeep Vidyapeeth (An Institute Deemed to be University), Piparia, Vadodara, Gujarat, India
  • Jayshri B Desai Professor, Department of Anaesthesiology, Smt. B. K. Shah Medical Institute and Research Center, Sumandeep Vidyapeeth (An Institute Deemed to be University), Piparia, Vadodara, Gujarat, India
  • Dinesh Chauhan Professor and Head, Department of Anaesthesiology, Smt. B. K. Shah Medical Institute and Research Center, Sumandeep Vidyapeeth (An Institute Deemed to be University), Piparia, Vadodara, Gujarat, India

Keywords:

etomidate, haemodynamic changes, induction agent, propofol

Abstract

Introduction: Laryngoscopy and endotracheal intubation are harmful stimuli that can produce adverse response in the cardiovascular, respiratory and other physiological systems. These changes are reflected in haemodynamic parameters which can be fatal for patients with low cardiac reserve and may alter the balance between myocardial oxygen supply and demand and as a result, myocardial ischemia can be precipitated. This observational comparative study was conducted to compare the haemodynamic effects of Propofol and Etomidate during induction of general anaesthesia in patients scheduled for elective surgery. Materials and Methods: 58 patients of American Society of Anaesthesiologists (ASA) physical status  I and II of age group 18-60 years scheduled for elective surgeries under general anaesthesia were randomly assigned in two groups (n=28). Group P received injection Propofol (2.5mg/kg) and group E received injection Etomidate (0.3mg/kg) during induction. Hemodynamic parameters were recorded at various time intervals. Statistical analysis was done using software (MedCalc Version 20.014). P value was considered significant if p £ 0.05. Results: Demographic profile was comparable in both the groups. Hemodynamic parameters at baseline and after premedication were comparable.

Downloads

Download data is not yet available.

References

Aggarwal, S., Goyal, V. K., Chaturvedi, S. K., Mathur, V., Baj, B., & Kumar, A. (2016). A comparative study between propofol and etomidate in patients under general anesthesia. Brazilian Journal of Anesthesiology (English Edition), 66(3), 237–241. https://doi.org/10.1016/j.bjane.2014.10.005

Choudhary, S., Sharma, S., Kumari, I., Kalluraya, S., Meena, K., & Dave, T. (2020). Comparative evaluation of oral melatonin and oral clonidine for the attenuation of haemodynamic response to laryngoscopy and tracheal intubation—A prospective randomised double blind study. Indian Journal of Anaesthesia, 64(8), 696. https://doi.org/10.4103/ija.IJA_76_20

Forman, S. A., & Warner, D. S. (2011). Clinical and Molecular Pharmacology of Etomidate. Anesthesiology, 114(3), 695–707. https://doi.org/10.1097/ALN.0b013e3181ff72b5

Khare, A., Thada, B., Samota, M., Mathur, V., & Singh, M. (2016). A randomised clinical study to compare the haemodynamic effects of etomidate with propofol during induction of general anaesthesia. International Journal of Research in Medical Sciences, 4593–4597. https://doi.org/10.18203/2320-6012.ijrms20163336

Kotani, Y., Shimazawa, M., Yoshimura, S., Iwama, T., & Hara, H. (2008). The Experimental and Clinical Pharmacology of Propofol, an Anesthetic Agent with Neuroprotective Properties. CNS Neuroscience & Therapeutics, 14(2), 95–106. https://doi.org/10.1111/j.1527-3458.2008.00043.x

Langley, M. S., & Heel, R. C. (1988). Propofol: A Review of its Pharmacodynamic and Pharmacokinetic Properties and Use as an Intravenous Anaesthetic. Drugs, 35(4), 334–372. https://doi.org/10.2165/00003495-198835040-00002

Meena, K., & Meena, R. (2016). A Comparative Study of Effect of Propofol, Etomidate and Propofol Plus Etomidate Induction on Hemodynamic Response to Endotracheal Intubation: A RCT. Journal of Anesthesia & Clinical Research, 07(05). https://doi.org/10.4172/2155-6148.1000622

Soleimani, A., Heidari, N., Habibi, M., Kiabi, F., Khademloo, M., Zeydi, A., & Sohrabi, F. (2017). Comparing Hemodynamic Responses to Diazepam, Propofol and Etomidate During Anesthesia Induction in Patients with Left Ventricular Dysfunction Undergoing Coronary Artery Bypass Graft Surgery: A Double-blind, Randomized Clinical Trial. Medical Archives, 71(3), 198. https://doi.org/10.5455/medarh.2017.71.198-203

Published

08-04-2022

How to Cite

Mehta, J. B., Sharma, T. H., Gopavajhula, V. S., Desai, J. B., & Chauhan, D. (2022). Comparison of haemodynamic response to induction with propofol versus etomidate in patients scheduled for elective surgery. International Journal of Health Sciences, 6(S2), 2832–2841. https://doi.org/10.53730/ijhs.v6nS2.5714

Issue

Vol. 6 No. S2 (2022)

Section

Peer Review Articles
Copyright & Licensing

Copyright (c) 2022 International journal of health sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.

Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.

Crossref
Scopus
Google Scholar
Europe PMC