Comparative assessment of the efficacy of lycopene alone to a combination of lycopene hyaluronidase for the treatment of oral submucous fibrosis

https://doi.org/10.53730/ijhs.v6nS2.5883

Authors

  • Khushboo Kumari Department of Oral Pathology, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India
  • Priyadarshini Rangari MDS, Associate professor, Department of Dentistry, Sri Shankaracharya Institute of Medical Sciences, Bhilai, Durg, Chhattisgarh, India
  • Sonal MDS, Senior Lecturer, Department of Conservative Dentistry and Endodontics, Dr. B. R. Ambedkar Institute of Dental Sciences and Hospital, Patna, Bihar, India
  • Ankur Jethlia Assistant Professor, Department Maxillofacial and Diagnostic sciences, Diagnostic Division College of Dentistry, Jazan University, Saudi Arabia

Keywords:

antioxidant, hyaluronidase, intralesional injections, lycopene, OSMF

Abstract

Background: OSMF is an oral precancerous condition with a high potential for malignant transformation. The main etiologic factor linked to OSMF is gutkha and tobacco chewing. Management of OSMF includes various therapies and drugs where the use of antioxidants has proven to be efficacious. Aim: The present study was conducted to compare and assess the efficacy of Lycopene antioxidant alone to its combination with intralesional injection of Hyaluronidase for managing the subjects with OSMF.Material and Method: The study included 54 subjects having stage 2 OSMF and were divided into 2 groups where the group I subjects were given lycopene daily in a dose of 8mg in two equal doses, whereas, group II subjects were given lycopene daily in a dose of 8mg combined with intralesional hyaluronidase injection of 1500 IU twice in a week for 3 months. VAS and inter-incisal mouth opening were assessed at baseline and 90th day after treatment completion.Results: At baseline, interincisal opening in Group I was 25.18±3.03mm and was 24.56±3.92mm in Group II. This difference was statistically non-significant with p=0.5184. On the 90th day, the last day of the study, interincisal opening in Group I was 29.34±3.19mm, whereas, in Group II was 32.39±3.24mm.

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References

Vashishth M, Chhabada A, Rangari P, Babjee KC. Comparison of intralesional hydrocortisone and hyaluronidase injection to surgical repair in manging the oral submucous fibrosis: A prospective clinical study. International Journal of Health and Clinical Research, 2021; 4(15):418-421.

Passi D, Bhanot P, Kacker D, Chahal D, Atri M, Panwar Y. Oral submucous fibrosis: Newer proposed classification with critical updates in pathogenesis and management strategies. Natl J Maxillofac Surg. 2017;8:89-94.

Bari S, Metgud R, Vyas Z, Tak A. An update on studies on etiological factors, disease progression, and malignant transformation in oral submucous fibrosis. J Cancer Res Ther. 2017;13:399-405.

Selvam NP, Dyanand AA. Lycopene in the management of oral submucous fibrosis. Ind J Dent Res. 2012;23:524-8.

Shah PH, Venkatesh R, More CB, Vassandacoumara V. Comparison of Therapeutic Efficacy of Placental Extract with Dexamethasone and Hyaluronic Acid with Dexamethasone for Oral Submucous Fibrosis - A Retrospective Analysis. J Clin Diagn Res. 2016;10:63-6.

Guduru H, Garlapati K, Solomon RV, Ignatius AV, Yeladandi M, Madireddy N. A comparative study of efficacy of intralesional corticosteroids and hyaluronidase therapy with and without ultrasound therapy in patients with oral submucous fibrosis. J Indian Acad Oral Med Radiol. 2019;31:11-6.

James L, Shetty A, Rishi D, Abraham M. Management of Oral Submucous Fibrosis with Injection of Hyaluronidase and Dexamethasone in Grade III Oral Submucous Fibrosis: A Retrospective Study. J Int Oral Health. 2015;7:82-5.

Guo J, Xie H, Mao S, Liang M, Wu H. Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: A meta-analysis of randomized controlled clinical trials. J Oral Pathol Med. 2020;49:311-9.

Buhren BA, Schrumpf H, Hoff NP, Bölke E, Hilton S, Greber PA. Hyaluronidase: from clinical applications to molecular and cellular mechanisms. Eur J Med Res. 2016;21:5.

Gupta N, Kalaskar A, Kalaskar R. Efficacy of lycopene in management of Oral Submucous Fibrosis- A systematic review and meta-analysis. J Oral BiolCraniofac Res. 2020;10:690-7.

Published

11-04-2022

How to Cite

Kumari, K., Rangari, P., Sonal, S., & Jethlia, A. (2022). Comparative assessment of the efficacy of lycopene alone to a combination of lycopene hyaluronidase for the treatment of oral submucous fibrosis. International Journal of Health Sciences, 6(S2), 4012–4017. https://doi.org/10.53730/ijhs.v6nS2.5883

Issue

Vol. 6 No. S2 (2022)

Section

Peer Review Articles
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