Antibiotic resistance pattern of Klebsiella pneumoniae a major problem for society
Keywords:
klebsiella pneumonia, resistance, sensitiveAbstract
Aim: Antibiotic resistance pattern of klebsiella pneumoniae a major problem for society. Methods: After ethical approval from the institutional ethical committee this study was done in the department of microbiology from April 2021 to march 2022 in genesis institute of dental science and research centre with collaboration of anil baghi hospital, firozpur, Punjab India. Demographic profile of all the patients like age, gender, history of any diseases was noted. All the sample like urine, sputum, blood, pleural fluid and urethral discharge were collected in the department for isolation and identification of K. pneumoniae. After 24hrs those were positive sample, further proceed for grams staining. B D Phoenix advanced automated microbiology system was used for identification and sensitivity of bacteria for 24hrs. Results: The study showed that highest number of patients having Klebsiella pneumonia were from 50-70 years having 20 (40%)patients followed by 30-50 years with 16 (32%), from Above 70 years 12 (24%) and below the age of 30 years having lowest number with two (4%) patients out of all patients. The number of male patients 33(66%) is more than females 17(34%).
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Gorrie, C. L., Mirceta, M., Wick, R. R., Edwards, D. J., Thomson, N. R., and Strugnell, R. A.Gastrointestinal carriage is a major reservoir of Klebsiella pneumoniae infection in intensive care patients. Clin. Infect. Dis.2017; 65, 208–215. doi: 10.1093/cid/cix270 DOI: https://doi.org/10.1093/cid/cix270
Fair, R. J., and Tor, Y. Antibiotics and bacterial resistance in the 21st Century. Perspect. Med. Chem.2014; 6, 25–64. doi: 10.4137/PMC.S14459. DOI: https://doi.org/10.4137/PMC.S14459
Davies, J., and Davies, D. Origins and evolution of antibiotic resistance.Microbiol. Mol. Biol. Rev.2010; 74, 417–433. doi: 10.1128/MMBR.00016-10 DOI: https://doi.org/10.1128/MMBR.00016-10
Infectious Diseases Society of America. Bad bugs, no drugs. Infectious Diseases Society of America, Alexandria, VA 2004. http://www.idsociety.org/pa/IDSA_Paper 4_final web.pdf.
Derakhshan, S., Peerayeh, S. N., and Bakhshi, B. Association between presence of virulence genes and antibiotic resistance in clinical Klebsiella Pneumoniae isolates. Lab. Med.2016; 47, 306–311. doi: 10.1093/labmed/lmw030 DOI: https://doi.org/10.1093/labmed/lmw030
Da Silva, G. J., and Mendonça, N. Association between antimicrobial resistance and virulence in Escherichia coli. Virulence.2012; 3, 18–28. doi: 10.4161/viru.3.1.18382 DOI: https://doi.org/10.4161/viru.3.1.18382
Vila, A., Cassata, A., Pagella, H., Amadio, C., Yeh, K.-M., Chang, F.-Y., et al. Appearance of Klebsiella Pneumoniae liver bscess syndrome in argentina: case report and review of molecular mechanisms of pathogenesis. OpenMicrobiol. J.2011;5, 107–113. doi: 10.2174/1874285801105010107 DOI: https://doi.org/10.2174/1874285801105010107
Navon-Venezia S, Kondratyeva K, Carattoli A. Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance. FEMS MicrobiolRev. 2017;41(3):252–75. DOI: https://doi.org/10.1093/femsre/fux013
Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology,taxonomy, typing methods, and pathogenicity factors. ClinMicrobiol Rev. 1998;11(4):589–603. DOI: https://doi.org/10.1128/CMR.11.4.589
Benedict, R.G.; Langlykke, A.F. Antibiotic activity of Bacillus polymyxa. J. Bacteriol. 1947;54, 24.
Poirel, L.; Jayol, A.; Nordmann, P. Polymyxins: Antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes. Clin. Microbiol. Rev. 2017;30, 557–596. DOI: https://doi.org/10.1128/CMR.00064-16
Arnold, R.S.; Thom, K.A.; Sharma, S.; Phillips, J.M.; Johnson, K.; Morgan, D.J. Emergence of Klebsiella pneumoniae Carbapenemase (KPC)-Producing Bacteria. South. Med. J. 2011;104, 40–45. DOI: https://doi.org/10.1097/SMJ.0b013e3181fd7d5a
Kwon, J.A.; Lee, J.E.; Huh,W.; Peck, K.R.; Kim, Y.G.; Kim, D.J.; Oh, H.Y. Predictors of acute kidney injury associated with intravenous colistin treatment. Int. J. Antimicrob. Agents 2010;35, 473–477. DOI: https://doi.org/10.1016/j.ijantimicag.2009.12.002
Pogue, J.M.; Lee, J.; Marchaim, D.; Yee, V.; Zhao, J.J.; Chopra, T.; Lephart, P.; Kaye, K.S. Incidence of and risk factors for colistin-associated nephrotoxicity in a large academic health system. Clin. Infect. Dis. 2011;53, 879–884. DOI: https://doi.org/10.1093/cid/cir611
Durante-Mangoni, E.; Andini, R.; Signoriello, S.; Cavezza, G.; Murino, P.; Buono, S.; De Cristofaro, M.;Taglialatela, C.; Bassetti, M.; Malacarne, P.; et al. Acute kidney injury during colistin therapy: A prospective study in patients with extensively-drug resistant Acinetobacter baumannii infections. Clin. Microbiol. Infect.2016, 22, 984–989. DOI: https://doi.org/10.1016/j.cmi.2016.08.004
European Centre for Disease Prevention and Control (ECDC). Antimicrobial Resistance Surveillance in Europe,2013; Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net); ECDC:
Stockholm S. Sutherland C.A.; Nicolau, D.P. Susceptibility profile of ceftolozane/tazobactam and other parenteral antimicrobials against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa from U.S. hospitals.Clin. Ther. 2015;37, 1564–1571. DOI: https://doi.org/10.1016/j.clinthera.2015.05.501
Meletis, G.; Oustas, E.; Botziori, C.; Kakasi, E.; Koteli, A. Containment of carbapenem resistance rates of Klebsiella pneumoniae and Acinetobacter baumannii in a Greek hospital with a concomitant increase in colistin, gentamicin and tigecycline resistance. New Microbiol. 2015;38, 417–421.
Pena, I.; Picazo, J.J.; Rodríguez-Avial, C.; Rodríguez-Avial, I. Carbapenemase-producing Enterobacteriaceae in a tertiary hospital in Madrid, Spain: High percentage of colistin resistance among VIM-1-producing Klebsiella pneumoniae ST11 isolates. Int. J. Antimicrob. Agents 2014;43, 460–464. DOI: https://doi.org/10.1016/j.ijantimicag.2014.01.021
Boucher, H. W., C. B. Wennersten, and G. M. Eliopoulos. In vitro activities of the glycylcycline GAR-936 against gram-positive bacteria. Antimicrob. Agents Chemother.2000;44:2225-2229. DOI: https://doi.org/10.1128/AAC.44.8.2225-2229.2000
Sun Y, Cai Y, Liu X, Bai N, Liang B, Wang R: The emergence of clinical resistance to tigecycline. Int J Antimicrob Agents. 2013;41: 110-6. DOI: https://doi.org/10.1016/j.ijantimicag.2012.09.005
Ben-David D, Kordevani R, Keller N, Tal I, Marzel A, Gal-Mor O, Maor Y, Rahav G: Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections. Clin Microbiol Infect. 2012;18: 54-60. DOI: https://doi.org/10.1111/j.1469-0691.2011.03478.x
Qureshi ZA, Paterson DL, Peleg AY, Adams-Haduch JM, Shutt KA, Pakstis DL, Sordillo E, Polsky B, Sandkovsky G, Bhussar MK, Doi Y: Clinical characteristics of bacteraemia caused by extended-spectrum β-lactamase-producing Enterobacteriaceae in the era of CTX-M-type and KPC-type β-lactamases. Clin Microbiol Infect. 2012; 18: 887-93. DOI: https://doi.org/10.1111/j.1469-0691.2011.03658.x
Kahan, F.M.; Kahan, J.S.; Cassidy, P.J.; Kropp, H. The mechanism of action of fosfomycin (phosphonomycin). Ann. N. Y. Acad. Sci. 1974;235, 364–386. DOI: https://doi.org/10.1111/j.1749-6632.1974.tb43277.x
Parker, S.L.; Frantzeskaki, F.; Wallis, S.C.; Diakaki, C.; Giamarellou, H.; Koulenti, D.; Karaiskos, I.;Lipman, J.; Dimopoulos, G.; Roberts, J.A. Population Pharmacokinetics of Fosfomycin in Critically Ill Patients. Antimicrob. Agents Chemother. 2015;59, 6471–6476. DOI: https://doi.org/10.1128/AAC.01321-15
Lorenzoni VV, Rubert FdC, Rampelotto RF, Hörner R. Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil. Rev Soc Bras Med Trop. 2018;51(5):676-9. doi: 10.1590/0037-8682-0362-2017 DOI: https://doi.org/10.1590/0037-8682-0362-2017
Ahanjan M, Naderi F, Solimanii A. Prevalence of Beta-lactamases Genes and Antibiotic Resistance Pattern of Klebsiella pneumoniae Isolated from Teaching Hospitals, Sari, Iran, 2014. J Mazandaran Univ Med Sci. 2017;27(149):79-87.
Manjula N, Math GC, Nagshetty K, Patil SA, Gaddad SM, Shivannavar CT. Antibiotic susceptibility pattern of ESβL producing Klebsiella pneumoniae isolated from urine samples of pregnant women in Karnataka. J Clin Diagn Res. 2014;8(10):DC08. doi: 10.7860/JCDR/2014/9594.5048. DOI: https://doi.org/10.7860/JCDR/2014/9594.5048
Osagie RN, Eyaufe AA, Iserhienrhien O, Okodua M, Onuabonah F, Daibo OO. Antibiotic suscepbility profile of Klebsiella pneumoniae isolated from sputum samples amongst hospitalized adults in parts of Edo state, south-south. Niger Merit Res J. 2017;5(8):378–83.
Akter J, Chowdhury AMMA, Al FM. Study on prevalence and antibiotic resistance pattern of Klebsiella isolated from clinical samples in south east region of Bangladesh. American J Drug Discov Dev. 2014;4:73–9. DOI: https://doi.org/10.3923/ajdd.2014.73.79
Zheng JX, Lin ZW, Chen C, Chen Z, Lin FJ, Wu Y, Yang SY, Sun X, Yao WM, Li DY, et al. Biofilm formation in Klebsiella pneumoniae bacteremia strains was found to be associated with CC23 and the presence of wcaG. Front Cell Infect Microbiol. 2018;8:21. DOI: https://doi.org/10.3389/fcimb.2018.00021
Gunn JS, Bakaletz LO, Wozniak DJ. What's on the outside matters: the role of the extracellular polymeric substance of gram-negative biofilms in evading host immunity and as a target for therapeutic intervention. J Biol Chem. 2016;291(24):12538–46. DOI: https://doi.org/10.1074/jbc.R115.707547
Meatherall BL, Gregson D, Ross T, Pitout JD, Laupland KB. Incidence, risk factors, and outcomes of Klebsiella pneumoniae bacteremia. Am J Med. 2009;122(9):866–73. DOI: https://doi.org/10.1016/j.amjmed.2009.03.034
Wang C, Yuan Z, Huang W, Yan L, Tang J, Liu CW. Epidemiologic analysis and control strategy of Klebsiella pneumoniae infection in intensive care units in a teaching hospital of People's Republic of China. Infect Drug Resist. 2019;12:391–8.
Wang C, Yuan Z, Huang W, Yan L, Tang J, Liu CW. Epidemiologic analysis and control strategy of Klebsiella pneumoniae infection in intensive care units in a teaching hospital of People's Republic of China. Infect Drug Resist. 2019;12:391–8. DOI: https://doi.org/10.2147/IDR.S189154
Seifi K, Kazemian H, Heidari H, Rezagholizadeh F, Saee Y, Shirvani F, Houri H. Evaluation of biofilm formation among Klebsiella pneumoniae isolates and molecular characterization by ERIC-PCR. Jundishapur J Microbiol. 2016;9(1): e30682. DOI: https://doi.org/10.5812/jjm.30682
Madahiah BM, Noor US, Abdul S, Dan Ali AQ. Klebsiella pneumoniae Urinary Tract Infections Associated with Long-term Catheterization and Spinal Cord Injuries. J Med Sci. 2002;2:227–9. DOI: https://doi.org/10.3923/jms.2002.227.229
Cepas V, Lopez Y, Munoz E, Rolo D, Ardanuy C, Marti S, Xercavins M, Horcajada JP, Bosch J, Soto SM. Relationship between biofilm formation and antimicrobial resistance in gram-negative Bacteria. Microb Drug Resist. 2019;25(1):72–9. DOI: https://doi.org/10.1089/mdr.2018.0027
Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health. 2015;109(7):309–18. DOI: https://doi.org/10.1179/2047773215Y.0000000030
Wu H, Moser C, Wang HZ, Hoiby N, Song ZJ. Strategies for combating bacterial biofilm infections. Int J Oral Sci. 2015;7(1):1–7. DOI: https://doi.org/10.1038/ijos.2014.65
Van der Meer JW, Gyssens IC. Quality of antimicrobial drug prescription in hospital. Clin Microbiol Infect. 2001;7(Suppl 6):12 –5. DOI: https://doi.org/10.1046/j.1469-0691.7.s6.3.x
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